The selective oestrogen receptor modulator, bazedoxifene, mimics the neuroprotective effect of 17β‐oestradiol in diabetic ischaemic stroke by modulating oestrogen receptor expression and the MAPK / ERK 1/2 signalling pathway

2019 ◽  
Vol 31 (8) ◽  
Author(s):  
María C. Burguete ◽  
Teresa Jover‐Mengual ◽  
Mikahela A. López‐Morales ◽  
Alicia Aliena‐Valero ◽  
María Jorques ◽  
...  
Keyword(s):  
Ischaemic Stroke ◽  
Oestrogen Receptor ◽  
Neuroprotective Effect ◽  
Signalling Pathway ◽  
Receptor Expression ◽  
Receptor Modulator ◽  
Selective Oestrogen Receptor Modulator

scholarly journals Reduction of oxidative stress and AT1 receptor expression by the selective oestrogen receptor modulator idoxifene

2001 ◽  
Vol 134 (3) ◽  
pp. 579-584 ◽  
Author(s):  
Anselm T Bäumer ◽  
Sven Wassmann ◽  
Katja Ahlbory ◽  
Kerstin Strehlow ◽  
Cornelius Müller ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oestrogen Receptor ◽  
At1 Receptor ◽  
Receptor Expression ◽  
Receptor Modulator ◽  
Selective Oestrogen Receptor Modulator

scholarly journals Single and multiple ascending dose studies of a novel tissue-selective oestrogen receptor modulator, CHF 4227, in healthy postmenopausal women

2007 ◽  
Vol 64 (3) ◽  
pp. 304-316 ◽  
Author(s):  
Maurizio Civelli ◽  
Alessandro Piero Monici Preti ◽  
Valentina Cenacchi ◽  
Ivano Rondelli ◽  
Daniele Guastalla ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Oestrogen Receptor ◽  
Receptor Modulator ◽  
Selective Oestrogen Receptor Modulator

scholarly journals Gonadotrope oestrogen receptor-α and -β and progesterone receptor immunoreactivity after ovariectomy and exposure to oestradiol benzoate, tamoxifen or raloxifene in the rat: correlation with LH secretion

2005 ◽  
Vol 184 (1) ◽  
pp. 59-68 ◽  
Author(s):  
J E Sánchez-Criado ◽  
J Martín de las Mulas ◽  
C Bellido ◽  
R Aguilar ◽  
J C Garrido-Gracia
Keyword(s):  
Progesterone Receptor ◽  
Oestrogen Receptor ◽  
Immunohistochemical Expression ◽  
Stimulatory Action ◽  
Receptor Modulator ◽  
Ovx Rats ◽  
Oestradiol Benzoate ◽  
Cycle Dependent ◽  
Lh Secretion ◽  
Selective Oestrogen Receptor Modulator

The selective oestrogen receptor modulator (SERM) tamoxifen (TX) has agonist/antagonist actions on LH secretion in the rat. Whereas in the absence of oestrogens TX elicits progesterone receptor (PR)-dependent GnRH self-priming, it antagonizes oestrogen-stimulatory action on LH secretion. The aim of these experiments was to explore whether TX treatment-induced differential expression of oestrogen receptor (ER)α and ERβ in the gonadotrope may determine its agonist effect on LH secretion. In the first experiment, basal LH secretion, GnRH-stimulated LH secretion and PR-dependent GnRH self-priming were determined in incubated pituitaries from ovariectomized (OVX) rats treated with oestradiol benzoate (EB), TX or raloxifene (RX). Cycling rats in metoestrus or pro-oestrus were used as basic controls. As in pro-oestrus, pituitaries from OVX rats treated with EB exhibited GnRH-stimulated LH secretion, immunohistochemical PR expression and GnRH self-priming. While RX had no effect on these parameters, TX induced PR expression and GnRH self-priming. GnRH self-priming was absent in pituitaries incubated with the antiprogestin ZK299. In the second experiment, we evaluated the immunohistochemical expression of ERα and ERβ in gonadotropes of cycling rats and OVX rats treated with EB, TX or RX. We found that while ERα expression was similar in all six groups, ERα expression was oestrous cycle dependent. Moreover, ERα expression in gonadotropes of TX-treated rats was as high as that found in pro-oestrus, while ERα expression in the gonadotropes of RX-treated rats was lower than in metoestrous or pro-oestrous pituitaries. These results suggest that, in the absence of the cognate ligand, TX, unlike RX, may regulate LH secretion through the ERα subtype in gonadotropes.

The Selective Oestrogen Receptor Modulator, LY362321, is Not Neuroprotective in a Rat Model of Transient Focal Ischaemia

2008 ◽  
Vol 20 (3) ◽  
pp. 366-374 ◽  
Author(s):  
T. D. Farr ◽  
H. V. O. Carswell ◽  
D. J. McCann ◽  
M. Sato ◽  
H. U. Bryant ◽  
...  
Keyword(s):  
Rat Model ◽  
Oestrogen Receptor ◽  
Receptor Modulator ◽  
Focal Ischaemia ◽  
Selective Oestrogen Receptor Modulator

scholarly journals Repurposing the Selective Oestrogen Receptor Modulator Tamoxifen for the Treatment of Duchenne Muscular Dystrophy

2018 ◽  
Vol 72 (4) ◽  
pp. 238-240 ◽  
Author(s):  
Elinam Gayi ◽  
Laurence A. Neff ◽  
Hesham M. Ismail ◽  
Urs T. Ruegg ◽  
Leonardo Scapozza ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Oestrogen Receptor ◽  
Receptor Modulator ◽  
Selective Oestrogen Receptor Modulator

Effects of the selective oestrogen receptor modulator-raloxifene-on calcium and PTH secretory dynamics in women with osteoporosis

2001 ◽  
Vol 54 (5) ◽  
pp. 575-582 ◽  
Author(s):  
A. Oleksik ◽  
T. Duong ◽  
C. Popp-Snijders ◽  
N. Pliester ◽  
G. Asma ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Receptor Modulator ◽  
Selective Oestrogen Receptor Modulator

Regression of hepatic adenomata after cessation of selective oestrogen receptor modulator

2009 ◽  
Vol 29 (1) ◽  
pp. 73-73 ◽  
Author(s):  
Kirstin A. Carswell ◽  
Ajay Belgaumkar ◽  
John Karani ◽  
Ameet G. Patel
Keyword(s):  
Oestrogen Receptor ◽  
Receptor Modulator ◽  
Selective Oestrogen Receptor Modulator
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