scholarly journals Histone deacetylase inhibitor treatment promotes spontaneous caregiving behaviour in non‐aggressive virgin male mice

2019 ◽  
Vol 31 (9) ◽  
Author(s):  
Heather S. Mayer ◽  
Marc Crepeau ◽  
Natalia Duque‐Wilckens ◽  
Lisette Y. Torres ◽  
Brian C. Trainor ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Male Mice ◽  
Deacetylase Inhibitor ◽  
Virgin Male ◽  
Inhibitor Treatment

scholarly journals Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors

2016 ◽  
Vol 22 (14) ◽  
pp. 3560-3570 ◽  
Author(s):  
Andrea Muscat ◽  
Dean Popovski ◽  
W. Samantha N. Jayasekara ◽  
Fernando J. Rossello ◽  
Melissa Ferguson ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Low Dose ◽  
Growth Arrest ◽  
Lineage Differentiation ◽  
Deacetylase Inhibitor ◽  
Rhabdoid Tumors ◽  
Inhibitor Treatment

scholarly journals Histone deacetylase inhibitor treatment attenuates coagulation imbalance in a lethal murine model of sepsis

Surgery ◽  
2014 ◽  
Vol 156 (2) ◽  
pp. 214-220 ◽  
Author(s):  
Ting Zhao ◽  
Yongqing Li ◽  
Baoling Liu ◽  
Erxi Wu ◽  
Martin Sillesen ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Murine Model ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor ◽  
Inhibitor Treatment

scholarly journals A novel non‐toxic histone deacetylase inhibitor enhances spatial memory consolidation in male mice

2020 ◽  
Vol 16 (S9) ◽  
Author(s):  
Sarah B Beamish ◽  
Jawad B Belayet ◽  
Samer Alanani ◽  
Doug A Steeber ◽  
Mahmun M Hossain ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Histone Deacetylase ◽  
Memory Consolidation ◽  
Histone Deacetylase Inhibitor ◽  
Male Mice ◽  
Deacetylase Inhibitor

scholarly journals Histone deacetylase inhibitor treatment promotes spontaneous caregiving behavior in C57BL/6J male mice

2018 ◽  
Author(s):  
H.S. Mayer ◽  
M. Crepeau ◽  
N. Duque-Wilckens ◽  
L.Y. Torres ◽  
B.C. Trainor ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Neural Circuit ◽  
Response Selection ◽  
Sexual Experience ◽  
Mammalian Species ◽  
Early Gene ◽  
Male Mice ◽  
Deacetylase Inhibitor ◽  
Hdaci Treatment

AbstractWhereas the majority of mammalian species are uni-parental with the mother solely provisioning care for young conspecifics, fathering behaviors can emerge under certain circumstances. For example, a great deal of individual variation in response to young pups has been reported in multiple inbred strains of laboratory male mice. Further, sexual experience and subsequent cohabitation with a female conspecific can induce caregiving responses in otherwise indifferent, fearful or aggressive males. Thus, a highly conserved parental neural circuit is likely present in both sexes, however the extent to which infants are capable of accessing this circuit may vary. In support of this idea, fearful or indifferent responses toward pups in female mice are linked to greater immediate early gene (IEG) expression in a fear/defensive circuit involving the anterior hypothalamus than in an approach/attraction circuit involving the ventral tegmental area. However, experience with infants, particularly in combination with histone deacetylase inhibitor (HDACi) treatment, can reverse this pattern of neuronal activation and behavior. Thus, HDACi treatment may increase the transcription of primed/poised genes that play a role in the activation and selection of a maternal approach circuit in response to pup stimuli. Here, we asked whether HDACi treatment would impact behavioral response selection and associated IEG expression changes in virgin male mice that are capable of ignoring, attacking or caring for pups. Our results indicate that systemic HDACi treatment induces spontaneous caregiving behavior in non-aggressive male mice and alters the pattern of pup-induced IEG expression across a fear/defensive neural circuit.

scholarly journals Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development

HemaSphere ◽  
2019 ◽  
Vol 3 (4) ◽  
pp. e270
Author(s):  
Anita M.A.P. Govers ◽  
Caroline R.M. Wiggers ◽  
Ruben van Boxtel ◽  
Michal Mokry ◽  
Edward E.S. Nieuwenhuis ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Distinct Gene ◽  
Deacetylase Inhibitor ◽  
Inhibitor Treatment
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