Sexual cues influence cocaine‐induced locomotion, anxiety and the immunoreactivity of oestrogen receptor alpha and tyrosine hydroxylase in both sexes

2019 ◽  
Vol 31 (6) ◽  
pp. e12720 ◽  
Author(s):  
Chen He ◽  
Jianli Wang ◽  
Ming Ma ◽  
Heng Wang
Keyword(s):  
Tyrosine Hydroxylase ◽  
Oestrogen Receptor ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha

A possible divergent role for the oestrogen receptor alpha and beta subtypes in clinical breast cancer

2000 ◽  
Vol 89 (2) ◽  
pp. 209-212 ◽  
Author(s):  
Janice M. Knowlden ◽  
Julia M.W. Gee ◽  
John F.R. Robertson ◽  
Ian O. Ellis ◽  
Robert I. Nicholson
Keyword(s):  
Breast Cancer ◽  
Oestrogen Receptor ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Clinical Breast

Oestrogen receptor alpha expression in neovaginal tissue of women following modified Abbé-McIndoe technique and in premenopausal women

2015 ◽  
Vol 31 (4) ◽  
pp. 327-331
Author(s):  
Marcio Masashi Kajikawa ◽  
Zsuzsanna Ilona Katalin Jármy-Di Bella ◽  
Juliane Dornelas ◽  
Luciana Campanatti Crema ◽  
Cláudia Cristina Takano ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Premenopausal Women ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha

scholarly journals Oestrogen's masculine side: mediation of mating in male mice

Reproduction ◽  
2002 ◽  
pp. 331-338 ◽  
Author(s):  
EM Scordalakes ◽  
DB Imwalle ◽  
EF Rissman
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Dopamine Agonist ◽  
Sexual Behaviour ◽  
Oestrogen Receptor ◽  
Neuronal Nitric Oxide Synthase ◽  
Receptor Alpha ◽  
Male Sexual Behaviour ◽  
Oestrogen Receptor Alpha ◽  
Oxide Synthase

This review focuses on the role of oestrogen in male sexual behaviour using oestrogen receptor alpha and beta knockout (ERalphaKO and ERbetaKO) mouse models. ERbetaKO mice are capable of mating and producing offspring, whereas ERalphaKO mice are unable to do either. When ERalphaKO males are treated with testosterone or dihydrotestosterone (DHT), < 50% display mounting behaviour, few intromit and none ejaculate. However, concurrent treatment with testosterone and a dopamine agonist instates masculine sexual behaviour in both male and female ERalphaKO mice. Dopamine content in the preoptic area and associated regions is not affected by oestrogen receptor alpha gene disruption. However, expression of neuronal nitric oxide synthase immunoreactivity is severely reduced in ERalphaKO males compared with wild-type males. These findings, together with studies conducted in aromatase knockout mice, are at odds with the dogma that oestrogen is required during development for expression of male sexual behaviour in adults. However, they do support a role for oestrogens, mediated by oestrogen receptor alpha, in regulation and production of neuronal nitric oxide synthase, which in turn may control dopamine agonist release. As has been shown in male rats, in mice dopamine agonist release is likely to be an essential component of the neural pathway that mediates male sexual behaviour.

scholarly journals Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure

2020 ◽  
Vol 2 (4) ◽  
pp. 351-363 ◽  
Author(s):  
J. Edward van Veen ◽  
Laura G. Kammel ◽  
Patricia C. Bunda ◽  
Michael Shum ◽  
Michelle S. Reid ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Oestrogen Receptor ◽  
Sexually Dimorphic ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha

scholarly journals Characterization of the interaction between hepatitis C virus NS5B and the human oestrogen receptor alpha

2012 ◽  
Vol 93 (4) ◽  
pp. 780-785 ◽  
Author(s):  
Julia Hillung ◽  
Elena Ruiz-López ◽  
Itxaso Bellón-Echeverría ◽  
Pilar Clemente-Casares ◽  
Antonio Mas
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Oestrogen Receptor ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Host Factors ◽  
Host Proteins ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha

The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is part of the viral replicative complex and plays a crucial role in HCV replication. It has been described that NS5B interacts with cellular proteins, and that interactions between NS5B and host proteins are crucial for viral replication. Some of the host factors involved in the HCV replication cycle include the oestrogen receptor alpha (ESR1), protein kinases (c-Src) and chaperones (Hsp70). In this report, we determine the requirements for the interplay between NS5B and the domain C of ESR1 (ESR1C) by using Förster Resonance Energy Transfer. NS5B–ESR1C and ESR1C–ESR1C interactions are dependent on ionic strength, indicating that contacts are mainly electrostatic. Additionally, NS5B residues involved in NS5B oligomerization were also essential for NS5B–ESR1C interaction. The study of the interactions among viral and host factors will provide data to establish innovative therapeutic strategies and the development of new antiviral drugs.

Sign in / Sign up

Export Citation Format

Share Document