Age‐dependent regulation by androgens of gene expression in the anterior hypothalamus and stress‐induced release of adrenal hormones in adolescent and adult male rats

2019 ◽  
Vol 31 (6) ◽  
pp. e12714 ◽  
Author(s):  
Matthew R. Green ◽  
Mostafa Zeidan ◽  
Travis E. Hodges ◽  
Cheryl M. McCormick
Keyword(s):  
Gene Expression ◽  
Adult Male ◽  
Anterior Hypothalamus ◽  
Male Rats ◽  
Adrenal Hormones ◽  
Age Dependent

Early maternal deprivation impairs learning and memory and alters hippocampal gene expression in adult male rats

2021 ◽  
pp. 107479
Author(s):  
Xiaofan Xiong ◽  
Lin Han ◽  
Meiyang Fan ◽  
Lingyu Zhang ◽  
Liying Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Learning And Memory ◽  
Adult Male ◽  
Maternal Deprivation ◽  
Male Rats

scholarly journals Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats

2013 ◽  
Vol 39 ◽  
pp. 100-109 ◽  
Author(s):  
Chase H. Bourke ◽  
Zachary N. Stowe ◽  
Gretchen N. Neigh ◽  
Darin E. Olson ◽  
Michael J. Owens
Keyword(s):  
Gene Expression ◽  
Prenatal Exposure ◽  
Adult Male ◽  
Male Rats ◽  
Or Gene

scholarly journals Effect of Coumarin on Memory Retention, Tissue Index, and GABAA Receptor Gene Expression in the Hippocampus of Gonadectomized Adult Male Rats

2021 ◽  
Vol 14 (11) ◽  
pp. 1-10
Author(s):  
Maryam Najafifard ◽  
Nasrin Heidarieh ◽  
Ali Haeri Rohani ◽  
Akram Eidi ◽  
◽  
...  
Keyword(s):  
Gene Expression ◽  
Gabaa Receptor ◽  
Adult Male ◽  
Receptor Gene ◽  
Male Rats ◽  
Memory Retention ◽  
Receptor Gene Expression

Effects of progesterone and RU486 on the development and expression of adult male sexual behaviour and gene expression in the amygdala and preoptic area of the hypothalamus

2012 ◽  
Vol 24 (7) ◽  
pp. 916 ◽  
Author(s):  
A. B. Breton ◽  
K. J. Austin ◽  
M. G. Leedy ◽  
B. M. Alexander
Keyword(s):  
Gene Expression ◽  
Adult Male ◽  
Sexual Behaviour ◽  
Preoptic Area ◽  
Corn Oil ◽  
Sexual Interest ◽  
Neonatal Rat ◽  
Male Rats ◽  
Altered Expression ◽  
Male Sexual Behaviour

The number of progesterone receptors is greater in the male than female neonatal rat hypothalamus. The aims of the present study were to determine developmental effects of progesterone on the expression of adult male sexual behaviour and whether changes in behaviour were reflected by altered gene expression within the hypothalamic preoptic area (POA) or medial amygdala. Male rats were treated with progesterone (40 µg kg–1, i.p.), the progesterone receptor antagonist RU486 (40 µg kg–1, i.p.) or an equal volume of vehicle (10% ethanol, 90% corn oil) on postnatal Days 1–5. Treatment with either progesterone or RU486 inhibited (P ≤ 0.07) the initial expression of consummatory sexual behaviour at 10.5 weeks of age without influencing growth or serum concentrations of testosterone. Sexual interest, as measured by latency to exhibiting mounting behaviour or the number of mounts achieved, was not influenced by treatment with either progesterone or RU486. The effects of treatment with progesterone or RU486 on sexual behaviour were diminished by experience. Microarray analysis of the POA indicated 61 genes that were upregulated and 49 that were downregulated (P ≤ 0.01) following RU486 treatment of male rats. However, the altered expression of selected genes was not confirmed by real-time reverse transcription–polymerase chain reaction. The expression of targeted genes within the amygdala was not influenced by treatment with either progesterone or RU486. Neonatal treatment with RU486, but not progesterone, decreased testes weight (P = 0.02) without affecting testes morphology. The results indicate that altering the progesterone environment during a critical developmental period affects the expression of behaviour, but that changes in behaviour are not mirrored by the altered expression of selected genes.

Po gene expression is modulated by androgens in the sciatic nerve of adult male rats

1999 ◽  
Vol 70 (1) ◽  
pp. 36-44 ◽  
Author(s):  
V Magnaghi ◽  
I Cavarretta ◽  
I Zucchi ◽  
L Susani ◽  
R Rupprecht ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sciatic Nerve ◽  
Adult Male ◽  
Male Rats

Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats

1999 ◽  
Vol 66 (1-2) ◽  
pp. 200-204 ◽  
Author(s):  
Steve C Danzer ◽  
Robin O Price ◽  
Nathaniel T. McMullen ◽  
Naomi E Rance
Keyword(s):  
Gene Expression ◽  
Adult Male ◽  
Arcuate Nucleus ◽  
Male Rats ◽  
Sex Steroid ◽  
Neurokinin B ◽  
Steroid Modulation

Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats

2017 ◽  
Vol 815 ◽  
pp. 304-311 ◽  
Author(s):  
Vitor Silva Pereira ◽  
Betina Elfving ◽  
Sâmia R.L. Joca ◽  
Gregers Wegener
Keyword(s):  
Gene Expression ◽  
Prefrontal Cortex ◽  
Adult Male ◽  
Male Rats
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