Modulation of synaptic inputs in magnocellular neurones in a rat model of cancer cachexia

2018 ◽  
Vol 30 (9) ◽  
pp. e12630
Author(s):  
Toru Yokoyama ◽  
Kiyoshi Terawaki ◽  
Kouichiro Minami ◽  
Kanako Miyano ◽  
Miki Nonaka ◽  
...  
Keyword(s):  
Rat Model ◽  
Cancer Cachexia ◽  
Synaptic Inputs

MT-102, A New Anabolic Catabolic Transforming Agent Improves Heart Function in a Rat Model of Cancer Cachexia

2012 ◽  
Vol 18 (8) ◽  
pp. S9
Author(s):  
Mareike Poetsch ◽  
Anika Tschirner ◽  
Sandra Palus ◽  
John Beadle ◽  
Andrew J.S. Coats ◽  
...  
Keyword(s):  
Rat Model ◽  
Cancer Cachexia ◽  
Heart Function

Rosiglitazone reduces body wasting and improves survival in a rat model of cancer cachexia

Nutrition ◽  
2014 ◽  
Vol 30 (9) ◽  
pp. 1069-1075 ◽  
Author(s):  
Katja Trobec ◽  
Sandra Palus ◽  
Anika Tschirner ◽  
Stephan von Haehling ◽  
Wolfram Doehner ◽  
...  
Keyword(s):  
Rat Model ◽  
Cancer Cachexia ◽  
Body Wasting

scholarly journals Ursodeoxycholic acid treatment in a rat model of cancer cachexia

2011 ◽  
Vol 3 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Anika Tschirner ◽  
Stephan von Haehling ◽  
Sandra Palus ◽  
Wolfram Doehner ◽  
Stefan D. Anker ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Rat Model ◽  
Acid Treatment ◽  
Cancer Cachexia

scholarly journals Rikkunshito Ameliorates Cancer Cachexia Partly through Elevation of Glucarate in Plasma

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Katsuya Ohbuchi ◽  
Shin Nishiumi ◽  
Naoki Fujitsuka ◽  
Tomohisa Hattori ◽  
Masahiro Yamamoto ◽  
...  
Keyword(s):  
Weight Loss ◽  
Herbal Medicine ◽  
Rat Model ◽  
Cancer Cachexia ◽  
Host Cells ◽  
Metabolome Analysis ◽  
Traditional Herbal Medicine ◽  
Delayed Onset ◽  
Tumor Bearing

Cancer cachexia, which is characterized by decreased food intake, weight loss and systemic inflammation, increases patient’s morbidity and mortality. We previously showed that rikkunshito (RKT), a Japanese traditional herbal medicine (Kampo), ameliorated the symptoms of cancer cachexia through ghrelin signaling-dependent and independent pathways. To investigate other mechanisms of RKT action in cancer cachexia, we performed metabolome analysis of plasma in a rat model bearing the Yoshida AH-130 hepatoma. A total of 110 metabolites were detected in plasma and RKT treatment significantly altered levels of 23 of those metabolites in cachexia model rats. Among them, glucarate, which is known to have anticarcinogenic activity through detoxification of carcinogens via inhibition ofβ-glucuronidase, was increased in plasma following administration of RKT. In our AH-130 ascites-induced cachexia rat model, administration of glucarate delayed onset of weight loss, improved muscle atrophy, and reduced ascites content. Additionally, glucarate reduced levels of plasma interferon-γ(IFN-γ) in tumor-bearing rats and was also found to suppress LPS-induced IFN-γexpression in splenocytesin vitro. These results suggest that glucarate has anti-inflammatory activity via a direct effect on immune host cells and suggest that RKT may also ameliorate inflammation partly through the elevation of glucarate in plasma.

Erythropoietin improves cardiac wasting and outcomes in a rat model of liver cancer cachexia

2016 ◽  
Vol 218 ◽  
pp. 312-317 ◽  
Author(s):  
Masakazu Saitoh ◽  
Michiyoshi Hatanaka ◽  
Masaaki Konishi ◽  
Junichi Ishida ◽  
Sandra Palus ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Rat Model ◽  
Cancer Cachexia

New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line

2014 ◽  
Vol 306 (4) ◽  
pp. E373-E387 ◽  
Author(s):  
Kiyoshi Terawaki ◽  
Yumi Sawada ◽  
Yohei Kashiwase ◽  
Hirofumi Hashimoto ◽  
Mitsuhiro Yoshimura ◽  
...  
Keyword(s):  
Weight Loss ◽  
Cell Line ◽  
Stomach Cancer ◽  
Rat Model ◽  
Cancer Cachexia ◽  
Peritoneal Dissemination ◽  
Cancer Cell Line ◽  
Human Stomach ◽  
Mrna Levels ◽  
Human Stomach Cancer

Cancer cachexia (CC), a syndrome characterized by anorexia and body weight loss due to low fat-free mass levels, including reduced musculature, markedly worsens patient quality of life. Although stomach cancer patients have the highest incidence of cachexia, few experimental models for the study of stomach CC have been established. Herein, we developed stomach CC animal models using nude rats subcutaneously implanted with two novel cell lines, i.e., MKN45c185, established from the human stomach cancer cell line MKN-45, and 85As2, derived from peritoneal dissemination of orthotopically implanted MKN45c185 cells in mice. Both CC models showed marked weight loss, anorexia, reduced musculature and muscle strength, increased inflammatory markers, and low plasma albumin levels; however, CC developed earlier and was more severe in rats implanted with 85As2 than in those implanted with MKN45cl85. Moreover, human leukemia inhibitory factor (LIF), a known cachectic factor, and hypothalamic orexigenic peptide mRNA levels increased in the models, whereas hypothalamic anorexigenic peptide mRNA levels decreased. Surgical removal of the tumor not only abolished cachexia symptoms but also reduced plasma LIF levels to below detectable limits. Importantly, oral administration of rikkunshito, a traditional Japanese medicine, substantially ameliorated CC-related anorexia and body composition changes. In summary, our novel peritoneal dissemination-derived 85As2 rat model developed severe cachexia, possibly caused by LIF from cancer cells, that was ameliorated by rikkunshito. This model should provide a useful tool for further study into the mechanisms and treatment of stomach CC.

Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia

Synapse ◽  
2012 ◽  
Vol 66 (8) ◽  
pp. 747-751 ◽  
Author(s):  
Masami Suzuki ◽  
Minoru Narita ◽  
Maho Ashikawa ◽  
Sadayoshi Furuta ◽  
Motohiro Matoba ◽  
...  
Keyword(s):  
Rat Model ◽  
Cancer Cachexia ◽  
Melanocortin Receptors

scholarly journals Ghrelin Treatment Causes Increased Food Intake and Retention of Lean Body Mass in a Rat Model of Cancer Cachexia

Endocrinology ◽  
2007 ◽  
Vol 148 (6) ◽  
pp. 3004-3012 ◽  
Author(s):  
Mark D. DeBoer ◽  
Xin Xia Zhu ◽  
Peter Levasseur ◽  
Michael M. Meguid ◽  
Susumu Suzuki ◽  
...  
Keyword(s):  
Food Intake ◽  
Lean Body Mass ◽  
Body Mass ◽  
Rat Model ◽  
Cancer Cachexia

scholarly journals A multifactorial anti-cachectic approach for cancer cachexia in a rat model undergoing chemotherapy

2015 ◽  
Vol 7 (1) ◽  
pp. 48-59 ◽  
Author(s):  
Míriam Toledo ◽  
Fabio Penna ◽  
Francesc Oliva ◽  
Melania Luque ◽  
Angelica Betancourt ◽  
...  
Keyword(s):  
Rat Model ◽  
Cancer Cachexia

scholarly journals IGF-1 treatment reduces weight loss and improves outcome in a rat model of cancer cachexia

2011 ◽  
Vol 2 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Katja Schmidt ◽  
Stephan von Haehling ◽  
Wolfram Doehner ◽  
Sandra Palus ◽  
Stefan D. Anker ◽  
...  
Keyword(s):  
Weight Loss ◽  
Rat Model ◽  
Cancer Cachexia
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