The Majority of Brain Palmitic Acid is Maintained by Lipogenesis from Dietary Sugars and is Augmented in Mice fed Low Palmitic Acid Levels from Birth

Fresh fruit bunches (FFB) consist of fruit be composed grade in few spikelet. Fruit at a spikelet can be distinguished into performed fruit namely internal fruit, middle fruit and outer fruit as soon as each section contain parthenocarpy fruits. This research was conducted for determine composition and content fatty acid of oil at internal fruit, middle, outer and parthenocarpy fruit from oil palm fruit. Samples of fruit came from 3 – 5 spikelet the central of FFB. Result showed that oil content of outer fruit (46.9 + 9.9)% trend higher be compared middle fruit (42.8 + 10.3)% and internal fruit (39.1 + 9.5)%. Parthenocarpy fruits have a low oil content (14.2 + 16.2)% except yellowish fruit trend high relatively oil content. The main components of fatty acid at outer fruit, middle and internal are palmitic acid, oleic, linoleic and stearic with mean value respectively (44.8 – 45.8)%, (37.6 – 38.0)%, (9.9 – 10.9)% and (4.6 – 4.8)%. Oil content at parthenocarpy fruit have amount main component of fatty acid with performed fruit but composition of palmitic acid (40.0 + 5.9)% and oleic (34.6 + 8.4)% lower while linoleic acid (16.9 + 8.5)% and linolenic (1.6 + 1.8)% higher be compared to performed fruit. Simalungun variety has the highest oil content in the part of fruit, with that PPKS 540 and La Mé respectively. PPKS 540 variety has the highest oleic acid content while PPKS 718 has the highest linoleic content.

Download Full-text

Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)39750-9 ◽

1995 ◽

Vol 36 (1) ◽

pp. 13-24

Author(s):

M M van Greevenbroek ◽

W F Voorhout ◽

D W Erkelens ◽

G van Meer ◽

T W de Bruin

Keyword(s):

Linoleic Acid ◽

Palmitic Acid ◽

Acid Metabolism ◽

Triglyceride Synthesis ◽

Lipoprotein Secretion ◽

Linoleic Acid Metabolism

Download Full-text

The transport and dynamic state of exogenous glycerol- and palmitic acid-labeled tripalmitin

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)39069-6 ◽

1960 ◽

Vol 1 (3) ◽

pp. 241-247

Author(s):

Raymond Reiser ◽

Mary C. Williams ◽

Mary F. Sorrels

Keyword(s):

Palmitic Acid ◽

Dynamic State

Download Full-text

Probing glycation potential of dietary sugars in human blood by an integrated in vitro approach

Food Chemistry ◽

10.1016/j.foodchem.2020.128951 ◽

2020 ◽

pp. 128951

Author(s):

Nadezhda Frolova ◽

Alena Soboleva ◽

Viet Duc Nguyen ◽

Ahyoung Kim ◽

Christian Ihling ◽

...

Keyword(s):

Human Blood ◽

Dietary Sugars

Download Full-text

Aqueous Extract of Pepino Leaves Ameliorates Palmitic Acid-Induced Hepatocellular Lipotoxicity via Inhibition of Endoplasmic Reticulum Stress and Apoptosis

Antioxidants ◽

10.3390/antiox10060903 ◽

2021 ◽

Vol 10 (6) ◽

pp. 903

Author(s):

Jen-Ying Hsu ◽

Hui-Hsuan Lin ◽

Charng-Cherng Chyau ◽

Zhi-Hong Wang ◽

Jing-Hsien Chen

Keyword(s):

Fatty Acid ◽

Palmitic Acid ◽

Er Stress ◽

Lipid Accumulation ◽

Hepg2 Cells ◽

Target Genes ◽

Liver Lipid ◽

Antioxidant Response ◽

Long Chain Fatty Acid ◽

Nrf2 Expression

Saturated fatty acid is one of the important nutrients, but contributes to lipotoxicity in the liver, causing hepatic steatosis. Aqueous pepino leaf extract (AEPL) in the previous study revealed alleviated liver lipid accumulation in metabolic syndrome mice. The study aimed to investigate the mechanism of AEPL on saturated long-chain fatty acid-induced lipotoxicity in HepG2 cells. Moreover, the phytochemical composition of AEPL was identified in the present study. HepG2 cells treated with palmitic acid (PA) were used for exploring the effect of AEPL on lipid accumulation, apoptosis, ER stress, and antioxidant response. The chemical composition of AEPL was analyzed by HPLC-ESI-MS/MS. AEPL treatment reduced PA-induced ROS production and lipid accumulation. Further molecular results revealed that AEPL restored cytochrome c in mitochondria and decreased caspase 3 activity to cease apoptosis. In addition, AEPL in PA-stressed HepG2 cells significantly reduced the ER stress and suppressed SREBP-1 activation for decreasing lipogenesis. For defending PA-induced oxidative stress, AEPL promoted Nrf2 expression and its target genes, SOD1 and GPX3, expressions. The present study suggested that AEPL protected from PA-induced lipotoxicity through reducing ER stress, increasing antioxidant ability, and inhibiting apoptosis. The efficacy of AEPL on lipotoxicity was probably concerned with kaempferol and isorhamnetin derived compounds.

Download Full-text