Thioredoxin interacting protein drives astrocytic glucose hypometabolism in corticosterone‐induced depressive state

2021 ◽  
Author(s):  
Shu‐Man Pan ◽  
Ying Pan ◽  
Ya‐Li Tang ◽  
Na Zuo ◽  
Yan‐Xiu Zhang ◽  
...  
Keyword(s):  
Depressive State ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein ◽  
Glucose Hypometabolism

miR-125b enhances metastasis and progression of cancer via the TXNIP and HIF1α pathway in pancreatic cancer

2021 ◽  
pp. 1-12
Author(s):  
Pengli Wang ◽  
Dan Zheng ◽  
Hongyang Qi ◽  
Qi Gao
Keyword(s):  
Pancreatic Cancer ◽  
Hypoxia Inducible Factor ◽  
Immunofluorescence Assay ◽  
Luciferase Assay ◽  
Interacting Protein ◽  
Over Expression ◽  
Thioredoxin Interacting Protein ◽  
Cellular Processes ◽  
And Migration

BACKGROUND: MicroRNAs (miRNAs) play potential role in the development of various types of cancer conditions including pancreatic cancer (PC) targeting several cellular processes. Present study was aimed to evaluate function of miR-125b and the mechanism involved in PC. METHODS: Cell migration, MTT and BrdU study was done to establish the migration capability, cell viability and cell proliferation respectively. Binding sites for miR-125b were recognized by luciferase assay, expression of protein by western blot and immunofluorescence assay. In vivo study was done by BALB/c nude xenograft mice for evaluating the function of miR-125b. RESULTS: The study showed that expression of miR-125b was elevated in PC cells and tissues, and was correlated to proliferation and migration of cells. Also, over-expression of miR-125b encouraged migration, metastasis and proliferation of BxPC-3 cells, the suppression reversed it. We also noticed that thioredoxin-interacting protein (TXNIP) was the potential target of miR-125b. The outcomes also suggested that miR-125b governed the expression of TXNIP inversely via directly attaching to the 3′-UTR activating hypoxia-inducible factor 1α (HIF1α). Looking into the relation between HIF1α and TXNIP, we discovered that TXNIP caused the degradation and export of HIF1α by making a complex with it. CONCLUSION: The miR-125b-TXNIP-HIF1α pathway may serve useful strategy for diagnosing and treating PC.

scholarly journals 374 Thioredoxin, thioredoxin interacting protein and galectin-3 in preeclampsia

2021 ◽  
Vol 224 (2) ◽  
pp. S243-S244
Author(s):  
Sivan Farladansky-Gershnabel ◽  
Ishai Heusler ◽  
Tal Biron-Shental ◽  
Keren Cohen-Hagai ◽  
Sydney Benchetrit ◽  
...  
Keyword(s):  
Interacting Protein ◽  
Thioredoxin Interacting Protein ◽  
Galectin 3

scholarly journals Thioredoxin interacting protein regulates age-associated neuroinflammation

2021 ◽  
pp. 105399
Author(s):  
Saifudeen Ismael ◽  
Sanaz Nasoohi ◽  
Lexiao Li ◽  
Khurram Aslam ◽  
Mohammad Moshahid Khan ◽  
...  
Keyword(s):  
Interacting Protein ◽  
Thioredoxin Interacting Protein

scholarly journals Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook

2021 ◽  
Vol 22 (5) ◽  
pp. 2754
Author(s):  
Naila Qayyum ◽  
Muhammad Haseeb ◽  
Moon Suk Kim ◽  
Sangdun Choi
Keyword(s):  
Interacting Protein ◽  
Thioredoxin Interacting Protein ◽  
Signaling Complex ◽  
Current Review ◽  
Wide Range ◽  
Range Of Functions ◽  
Species Production ◽  
And Oxidative Stress ◽  
Significant Attention

Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is pivotal for the pathophysiology of some diseases. TXNIP increases reactive oxygen species production and oxidative stress and thereby contributes to apoptosis. Recent studies indicate an evolving role of TXNIP in the pathogenesis of complex diseases such as metabolic disorders, neurological disorders, and inflammatory illnesses. In addition, TXNIP has gained significant attention due to its wide range of functions in energy metabolism, insulin sensitivity, improved insulin secretion, and also in the regulation of glucose and tumor suppressor activities in various cancers. This review aims to highlight the roles of TXNIP in the field of diabetology, neurodegenerative diseases, and inflammation. TXNIP is found to be a promising novel therapeutic target in the current review, not only in the aforementioned diseases but also in prolonged microvascular and macrovascular diseases. Therefore, TXNIP inhibitors hold promise for preventing the growing incidence of complications in relevant diseases.

scholarly journals Long Non-coding RNA GAS5 Worsens Coronary Atherosclerosis Through MicroRNA-194-3p/TXNIP Axis

2021 ◽  
Author(s):  
Yanbing Li ◽  
Yu Geng ◽  
Boda Zhou ◽  
Xuejiao Wu ◽  
Ou Zhang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Coronary Atherosclerosis ◽  
Growth Arrest ◽  
Interacting Protein ◽  
Expression Levels ◽  
Thioredoxin Interacting Protein ◽  
Non Coding Rna ◽  
Proliferation And Apoptosis ◽  
Regulatory Effects ◽  
Long Non Coding Rna

AbstractIt is formerly conducted that long non-coding RNA growth arrest-specific 5 (GAS5) is involved in the process of coronary atherosclerosis (AS). The regulatory effects of GAS5 on the microRNA (miR)-194-3p/thioredoxin-interacting protein (TXNIP) axis in AS have been insufficiently explored yet. Thereafter, this work is started from GAS5/miR-194-3p/TXNIP axis in AS. AS rats were modeled to obtain their coronary vascular tissues and endothelial cells (ECs), in which GAS5, miR-194-3p, and TXNIP expression were tested. ECs were identified by immunohistochemistry. The mechanism among GAS5, miR-194-3p, and TXNIP was determined. ECs were transfected with inhibited GAS5 or overexpressed miR-194-3p to decipher their functions in proliferation and apoptosis of ECs in AS. Raised GAS5 and TXNIP and degraded miR-194-3p expression levels exhibited in AS. GAS5 bound to miR-194-3p while miR-194-3p targeted TXNIP. Depleting GAS5 or restoring miR-194-3p enhanced proliferation and depressed apoptosis of ECs in AS. This work clearly manifests that inhibited GAS5 facilitates the growth of ECs through miR-194-3p-targeted TXNIP in AS, consolidating the basal reference to the curing for AS.

scholarly journals Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney

2016 ◽  
Vol 89 (2) ◽  
pp. 342-353 ◽  
Author(s):  
Yang De Marinis ◽  
Mengyin Cai ◽  
Pradeep Bompada ◽  
David Atac ◽  
Olga Kotova ◽  
...  
Keyword(s):  
Epigenetic Regulation ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein

scholarly journals Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury

2014 ◽  
Vol 171 (5) ◽  
pp. 1299-1313 ◽  
Author(s):  
M F El-Azab ◽  
B R B Baldowski ◽  
B A Mysona ◽  
A Y Shanab ◽  
I N Mohamed ◽  
...  
Keyword(s):  
Vascular Injury ◽  
Neuronal Function ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein
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