α‐Conotoxin Bt1.8 from Conus betulinus selectively inhibits α6/α3β2β3 and ɑ3β2 nicotinic acetylcholine receptor subtypes

2021 ◽  
Author(s):  
Huying Ning ◽  
Biling Huang ◽  
Han‐Shen Tae ◽  
Zhuguo Liu ◽  
Shuo Yu ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine ◽  
Conus Betulinus

scholarly journals Firing responses mediated via distinct nicotinic acetylcholine receptor subtypes in rat prepositus hypoglossi nuclei neurons

2018 ◽  
Vol 120 (4) ◽  
pp. 1525-1533
Author(s):  
Yue Zhang ◽  
Yuchio Yanagawa ◽  
Yasuhiko Saito
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Firing Frequency ◽  
Membrane Properties ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine ◽  
Firing Patterns ◽  
Prepositus Hypoglossi ◽  
Specific Antagonist ◽  
The Relationship

We previously reported that cholinergic current responses mediated via nicotinic acetylcholine (ACh) receptors (nAChRs) in the prepositus hypoglossi nucleus (PHN), which participates in gaze control, can be classified into distinct types based on different kinetics and are mainly composed of α7- and/or non-α7-subtypes: fast (F)-, slow (S)-, and fast and slow (FS)-type currents. In this study, to clarify how each current type is related to neuronal activities, we investigated the relationship between the current types and the membrane properties and the firing responses that were induced by each current type. The proportion of the current types differed in neurons that exhibited different afterhyperpolarization (AHP) profiles and firing patterns, suggesting that PHN neurons show a preference for specific current types dependent on the membrane properties. In response to ACh, F-type neurons showed either one action potential (AP) or multiple APs with a short firing duration, and S-type neurons showed multiple APs with a long firing duration. The firing frequency of F-type neurons was significantly higher than that of S-type and FS-type neurons. An α7-subtype-specific antagonist abolished the firing responses of F-type neurons and reduced the responses of FS-type neurons but had little effect on the responses of S-type neurons, which were reduced by a non-α7-subtype-specific antagonist. These results suggest that the different properties of the current types and the distinct expression of the nAChR subtypes in PHN neurons with different membrane properties produce unique firing responses via the activation of nAChRs. NEW & NOTEWORTHY Prepositus hypoglossi nucleus (PHN) neurons show distinct nicotinic acetylcholine receptor (nAChR)-mediated current responses. The proportion of the current types differed in the neurons that exhibited different afterhyperpolarization profiles and firing patterns. The nAChR-mediated currents with different kinetics induced firing responses of the neurons that were distinct in the firing frequency and duration. These results suggest that the different properties of the current types in PHN neurons with different membrane properties produce unique firing responses via the activation of nAChRs.

Expression of nicotinic acetylcholine receptor subtypes in brain and retina

1991 ◽  
Vol 10 (1) ◽  
pp. 61-70 ◽  
Author(s):  
P.J. Whiting ◽  
R. Schoepfer ◽  
W.G. Conroy ◽  
M.J. Gore ◽  
K.T. Keyser ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine

scholarly journals Inhibition of Neuronal Nicotinic Acetylcholine Receptor Subtypes by α-Conotoxin GID and Analogues

2008 ◽  
Vol 284 (8) ◽  
pp. 4944-4951 ◽  
Author(s):  
Emma L. Millard ◽  
Simon T. Nevin ◽  
Marion L. Loughnan ◽  
Annette Nicke ◽  
Richard J. Clark ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Neuronal Nicotinic Acetylcholine Receptor ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine

Nicotinic Acetylcholine Receptor Subtypes Expression during Rat Retina Development and Their Regulation by Visual Experience

2004 ◽  
Vol 66 (1) ◽  
pp. 85-96 ◽  
Author(s):  
Milena Moretti ◽  
Silvia Vailati ◽  
Michele Zoli ◽  
Giordano Lippi ◽  
Loredana Riganti ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Visual Experience ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine ◽  
Rat Retina ◽  
Retina Development

RIC-3 Enhances Functional Expression of Multiple Nicotinic Acetylcholine Receptor Subtypes in Mammalian Cells

2005 ◽  
Vol 68 (5) ◽  
pp. 1431-1438 ◽  
Author(s):  
Stuart J. Lansdell ◽  
Veronica J. Gee ◽  
Patricia C. Harkness ◽  
Anne I. Doward ◽  
Elizabeth R. Baker ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Mammalian Cells ◽  
Functional Expression ◽  
Receptor Subtypes ◽  
Nicotinic Acetylcholine
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