Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia

2021 ◽  
Author(s):  
Jin‐Qiong Zhan ◽  
Chun‐Nuan Chen ◽  
Si‐Xian Wu ◽  
Han‐Jun Wu ◽  
Ke Zou ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Cognitive Function ◽  
Rat Model ◽  
Male Rat ◽  
Hippocampal Synaptic Plasticity

P2-030: DPP-4 inhibitor improves brain insulin sensitivity, but fails to restore hippocampal synaptic plasticity and cognitive function in testosterone-deprived obese rats

2015 ◽  
Vol 11 (7S_Part_10) ◽  
pp. P492-P493
Author(s):  
Hiranya Pintana ◽  
Wanpitak Pongkan ◽  
Wasana Pratchayasakul ◽  
Nipon Chattipakorn ◽  
Siriporn C. Chattipakorn
Keyword(s):  
Synaptic Plasticity ◽  
Cognitive Function ◽  
Insulin Sensitivity ◽  
Hippocampal Synaptic Plasticity ◽  
Brain Insulin ◽  
Obese Rats

scholarly journals Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation

2006 ◽  
Vol 23 (10) ◽  
pp. 2739-2748 ◽  
Author(s):  
Jaime L. Tartar ◽  
Christopher P. Ward ◽  
James T. McKenna ◽  
Mahesh Thakkar ◽  
Elda Arrigoni ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Spatial Learning ◽  
Rat Model ◽  
Sleep Fragmentation ◽  
Hippocampal Synaptic Plasticity

scholarly journals Energy restriction combined with dipeptidyl peptidase-4 inhibitor exerts neuroprotection in obese male rats

2016 ◽  
Vol 116 (10) ◽  
pp. 1700-1708 ◽  
Author(s):  
Hiranya Pintana ◽  
Pongpan Tanajak ◽  
Wasana Pratchayasakul ◽  
Piangkwan Sa-nguanmoo ◽  
Titikorn Chunchai ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Synaptic Plasticity ◽  
Cognitive Function ◽  
Insulin Sensitivity ◽  
Mitochondrial Function ◽  
Male Rats ◽  
Insulin Resistant ◽  
Hippocampal Synaptic Plasticity ◽  
Brain Insulin ◽  
Brain Mitochondrial Function

AbstractDipeptidyl peptidase-4 (DDP-4) inhibitors and energy restriction (ER) are widely used to treat insulin resistance and type 2 diabetes mellitus. However, the effects of ER or the combination with vildagliptin on brain insulin sensitivity, brain mitochondrial function, hippocampal synaptic plasticity and cognitive function in obese insulin-resistant rats have never been investigated. We hypothesised that ER with DDP-4 inhibitor exerts better efficacy than ER alone in improving cognition in obese insulin-resistant male rats by restoring brain insulin sensitivity, brain mitochondrial function and hippocampal synaptic plasticity. A total of twenty-four male Wistar rats were divided into two groups and fed either a normal diet or a high-fat diet (HFD) for 12 weeks. At week 13, the HFD rats were divided into three subgroups (n 6/subgroup) to receive one of the following treatments: vehicle, ER (60 % of energy received during the previous 12 weeks) or ER plus vildagliptin (3 mg/kg per d, p.o.) for 4 weeks. At the end of the treatment, cognitive function, metabolic parameters, brain insulin sensitivity, hippocampal synaptic plasticity and brain mitochondrial function were determined. We found that HFD-fed rats demonstrated weight gain with peripheral insulin resistance, dyslipidaemia, oxidative stress, brain insulin resistance, impaired brain mitochondrial function and cognitive dysfunction. Although HFD-fed rats treated with ER and ER plus vildagliptin showed restored peripheral insulin sensitivity and improved lipid profiles, only ER plus vildagliptin rats had restored brain insulin sensitivity, brain mitochondrial function, hippocampal synaptic plasticity and cognitive function. These findings suggest that only a combination of ER with DPP-4 inhibitor provides neuroprotective effects in obese insulin-resistant male rats.

scholarly journals Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS

Cell Reports ◽  
2020 ◽  
Vol 31 (7) ◽  
pp. 107666 ◽  
Author(s):  
Shirin Hosseini ◽  
Kristin Michaelsen-Preusse ◽  
Gayane Grigoryan ◽  
Chintan Chhatbar ◽  
Ulrich Kalinke ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Cognitive Function ◽  
Type I Interferon ◽  
Type I ◽  
Receptor Signaling ◽  
Hippocampal Synaptic Plasticity ◽  
Interferon Receptor
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