scholarly journals Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse

2021 ◽  
Author(s):  
Susan Schenk ◽  
Quenten Highgate
Keyword(s):  
Dopaminergic Mechanisms

scholarly journals Preliminary Pharmacogenetic Study to Explore Putative Dopaminergic Mechanisms of Antidepressant Action

2021 ◽  
Vol 11 (8) ◽  
pp. 731
Author(s):  
Taichi Ochi ◽  
Natalya M. Vyalova ◽  
Innokentiy S. Losenkov ◽  
Diana Z. Paderina ◽  
Ivan V. Pozhidaev ◽  
...  
Keyword(s):  
Depressive Disorders ◽  
Rating Scale ◽  
Bipolar Depression ◽  
Sufficient Evidence ◽  
Therapeutic Effects ◽  
Pharmacogenetic Study ◽  
Dopaminergic Mechanisms ◽  
Major Depressive Disorders ◽  
Related Proteins ◽  
Antidepressant Action

Background: There is sufficient evidence that interference of dopaminergic neurotransmission contributes to the therapeutic effects of antidepressants in unipolar and bipolar depression. Methods: Hamilton depression rating scale (HAMD 17) scores of 163 at least moderately ill patients with major depressive disorders were used to establish treatment response. HAMD 17 score status was measured before initiation, after two weeks, and after four weeks of treatment with various antidepressants. The possible association between response and genotype in a total of 14 variants of dopamine neurotransmission-related proteins was investigated. Results: DRD4 rs11246226 CA heterozygous patients were found with a greater improvement of HAMD 17 score when compared to homozygous C patients during 0–2 weeks and 0–4 weeks. Patients with MAOB rs1799836 heterozygous GA and homozygous A also demonstrated improved scores during 2–4 weeks and 0–4 weeks. Conclusions: The results are preliminary due to the limited population size and the small number of variants. Further research into the involvement of habenular dopamine D4 receptors in the antidepressant response is desirable.

Dopaminergic mechanisms controlling urethral function in rats

2006 ◽  
Vol 25 (5) ◽  
pp. 480-489 ◽  
Author(s):  
Teruyuki Ogawa ◽  
Satoshi Seki ◽  
Hitoshi Masuda ◽  
Yasuhiko Igawa ◽  
Osamu Nishizawa ◽  
...  
Keyword(s):  
Dopaminergic Mechanisms ◽  
Urethral Function

scholarly journals Dopaminergic Mechanisms in Idiopathic and Drug-induced Psychoses

1990 ◽  
Vol 16 (1) ◽  
pp. 97-110 ◽  
Author(s):  
J. A. Lieberman ◽  
B. J. Kinon ◽  
A. D. Loebel
Keyword(s):  
Drug Induced ◽  
Dopaminergic Mechanisms

Dopaminergic mechanisms in heart failure

1990 ◽  
Vol 22 ◽  
pp. 422
Author(s):  
R. Razzolini ◽  
P. Ostan ◽  
A. Ramondo ◽  
P. Stritoni ◽  
R. Chioin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dopaminergic Mechanisms

scholarly journals Optogenetic approaches for the analysis of the role of dopaminergic neurotransmission in the development of alcohol dependence: from correlations to mechanisms

2019 ◽  
pp. 39-40
Author(s):  
E. A. Budygin
Keyword(s):  
Alcohol Drinking ◽  
Dopamine Release ◽  
Drinking Behavior ◽  
Brain Regions ◽  
Alcohol Addiction ◽  
Addictive Behaviors ◽  
Technological Advances ◽  
Dopaminergic Mechanisms ◽  
Neurochemical Changes

Despite many years of work on dopaminergic mechanisms of alcohol addiction, much of this evidence remains mostly correlative in nature. Fortunately, the latest technological advances have provided the opportunity to explore the causal role of neurochemical changes within brain regions involved in addictive behaviors. In this work using optogenetics, we have attempted to answer the question of how dopamine release dynamics control the motivational component of alcohol drinking behavior.

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