Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission

2020 ◽  
Vol 154 (1) ◽  
pp. 56-70
Author(s):  
Raquel García‐García ◽  
Juan F. Guerrero ◽  
Manuel Lavilla‐Miyasato ◽  
Jose R. Magdalena ◽  
Juan F. Ordoño ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Mismatch Negativity ◽  
Evoked Potential ◽  
Auditory Evoked Potential

scholarly journals Mismatch Negativity Occurrence with Verbal and Nonverbal Stimuli in Normal-Hearing Adults

2020 ◽  
Vol 24 (02) ◽  
pp. e182-e190
Author(s):  
Mirtes Brückmann ◽  
Michele Vargas Garcia
Keyword(s):  
Reference Values ◽  
Mismatch Negativity ◽  
Evoked Potential ◽  
Normal Hearing ◽  
Verbal Stimulus ◽  
Auditory Evoked Potential ◽  
High Contrast ◽  
Auditory Event ◽  
Long Latency ◽  
Significant Difference

Abstract Introduction The mismatch negativity (MMN) is a long-latency auditory evoked potential related to a passive elicited auditory event. Objective To verify the occurrence of MMN with different stimuli, to describe reference values in normal-hearing adults with verbal and nonverbal stimuli and to compare them with each other, besides analyzing the latency, area, and amplitude regarding gender and between the ears. Method Normal-hearing individuals, aged between 18 and 59 years old, participated in the study. As inclusion criterion in the study, all of them underwent tone threshold audiometry, logoaudiometry, tympanometry, and the Dichotic Sentence Identification (DSI) test, and later the MMN with 4 different stimuli, being 2 verbal (da/ta and ba/di) and 2 nonverbal stimuli (750/1,000Hz and 750/4,000Hz), which are considered stimuli with low and high contrast. Results A total of 90 individuals composed the sample, being 39 males and 51 females, with an average age of 26.9 years old. In the analysis of the latency, amplitude, and area of the four stimuli between the ears, they were not considered statistically different. There was a significant difference between all of the stimuli in terms of latency, amplitude and area, with the highest latency found in da/ta, and the greatest amplitude and area in ba/di. Regarding gender, there was only difference in the latency of the da/ta stimulus. Conclusion The da/ta and 750/1,000Hz stimuli elicited the most MMN in the population of normal-hearing adults. Among the genders, there was difference only regarding the latency of the verbal stimulus da/ta, and there was no difference between the ears.

scholarly journals Effect of propofol anaesthesia on the event-related potential mismatch negativity and the auditory-evoked potential N1

2002 ◽  
Vol 89 (3) ◽  
pp. 382-388 ◽  
Author(s):  
T.P. Simpson ◽  
A.R. Manara ◽  
N.M. Kane ◽  
R.L. Barton ◽  
C.A. Rowlands ◽  
...  
Keyword(s):  
Mismatch Negativity ◽  
Evoked Potential ◽  
Event Related Potential ◽  
Auditory Evoked Potential

scholarly journals Mismatch negativity and adaptation measures of the late auditory evoked potential in cochlear implant users

2011 ◽  
Vol 275 (1-2) ◽  
pp. 17-29 ◽  
Author(s):  
Fawen Zhang ◽  
Theresa Hammer ◽  
Holly-Lolan Banks ◽  
Chelsea Benson ◽  
Jing Xiang ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Mismatch Negativity ◽  
Evoked Potential ◽  
Auditory Evoked Potential ◽  
Adaptation Measures

Interaction of estrogen with central serotonergic mechanisms in human sensory processing: loudness dependence of the auditory evoked potential and mismatch negativity

2010 ◽  
Vol 25 (12) ◽  
pp. 1614-1622 ◽  
Author(s):  
Valérie Guille ◽  
Andrea Gogos ◽  
Pradeep J Nathan ◽  
Rodney J Croft ◽  
Maarten van den Buuse
Keyword(s):  
Auditory Processing ◽  
Mismatch Negativity ◽  
Repeated Measures ◽  
Evoked Potential ◽  
Partial Agonist ◽  
Auditory Evoked Potential ◽  
Double Blind ◽  
Repeated Measures Design ◽  
Loudness Dependence ◽  
Pre Treatment

Estrogen may be involved in schizophrenia by inhibiting serotonin-1A (5-HT1A) receptor function. We examined the effects of estrogen pre-treatment on modulation of loudness dependence of the auditory evoked potential (LDAEP) and mismatch negativity by the 5-HT1A receptor partial agonist, buspirone. Using a double-blind, placebo-controlled, repeated-measures design in healthy female volunteers, we observed that buspirone treatment significantly increased LDAEP slope. Estrogen increased LDAEP slope on its own, and a further LDAEP increase by buspirone was not seen after estrogen pre-treatment. Similar results were observed for mismatch negativity, where buspirone caused a small increase of latency, although not amplitude, after placebo but not estrogen pre-treatment, which enhanced mismatch negativity latency on its own. These results are in line with our previous findings on prepulse inhibition showing an inhibitory effect of estrogen on the action of buspirone. Taken together, these data suggest that estrogen may inhibit 5-HT1A receptor-mediated disruptions of auditory processing.

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