Metabotropic glutamate receptor 5 (mGlu
            5
            )‐positive allosteric modulators differentially induce or potentiate desensitization of mGlu
            5
            signaling in recombinant cells and neurons

Shane D. Hellyer; Sabine Albold; Kathy Sengmany; Junaid Singh; Katie Leach; Karen J. Gregory

doi:10.1111/jnc.14844

Metabotropic glutamate receptor 5 (mGlu 5 )‐positive allosteric modulators differentially induce or potentiate desensitization of mGlu 5 signaling in recombinant cells and neurons

Journal of Neurochemistry ◽

10.1111/jnc.14844 ◽

2019 ◽

Vol 151 (3) ◽

pp. 301-315 ◽

Cited By ~ 2

Author(s):

Shane D. Hellyer ◽

Sabine Albold ◽

Kathy Sengmany ◽

Junaid Singh ◽

Katie Leach ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Recombinant Cells ◽

Positive Allosteric Modulators

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Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.10.050 ◽

2015 ◽

Vol 25 (24) ◽

pp. 5792-5796 ◽

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Author(s):

John M. Ellard ◽

Andrew Madin ◽

Oliver Philps ◽

Mark Hopkin ◽

Scott Henderson ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Preclinical Model ◽

Allosteric Modulators ◽

Improve Performance ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement

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10.1124/jpet.113.206623 ◽

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E.J. Herman ◽

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A.S. Hammond ◽

N.E. Byun ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Cognitive Enhancement ◽

Allosteric Modulators ◽

Preclinical Models ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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10.1021/acsmedchemlett.6b00292 ◽

2016 ◽

Vol 7 (12) ◽

pp. 1082-1086 ◽

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...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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British Journal of Pharmacology ◽

10.1111/bph.12164 ◽

2013 ◽

Vol 169 (4) ◽

pp. 909-921 ◽

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FR Silva ◽

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TG Carvalho ◽

...

Keyword(s):

Mouse Model ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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pp. 328-341

Author(s):

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Thor C. Møller ◽

Shane D. Hellyer ◽

Line Vedel ◽

Simon R. Foster ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004–2012)

Pharmaceutical Patent Analyst ◽

10.4155/ppa.12.82 ◽

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Vol 2 (1) ◽

pp. 93-108 ◽

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Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2014.04.087 ◽

2014 ◽

Vol 24 (15) ◽

pp. 3641-3646 ◽

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Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Ligand Efficiency ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators ◽

High Ligand

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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.01.038 ◽

2015 ◽

Vol 25 (6) ◽

pp. 1310-1317 ◽

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Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

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Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Positive Allosteric Modulators

Download Full-text