scholarly journals Current status and potential role of circular RNAs in neurological disorders

2019 ◽  
Vol 150 (3) ◽  
pp. 237-248 ◽  
Author(s):  
Shanshan Lu ◽  
Xue Yang ◽  
Chudong Wang ◽  
Siqi Chen ◽  
Shuang Lu ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Potential Role ◽  
Current Status ◽  
Circular Rnas

scholarly journals Advances in the Identification of Circular RNAs and Research Into circRNAs in Human Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Shihu Jiao ◽  
Song Wu ◽  
Shan Huang ◽  
Mingyang Liu ◽  
Bo Gao
Keyword(s):  
Neurological Disorders ◽  
Closed Loop ◽  
Significant Proportion ◽  
Human Diseases ◽  
Circular Rnas ◽  
The Status ◽  
Research Questions ◽  
Non Coding Rnas ◽  
Microrna Sponges

Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs (ncRNAs) with a closed-loop structure that are mainly produced by variable processing of precursor mRNAs (pre-mRNAs). They are widely present in all eukaryotes and are very stable. Currently, circRNA studies have become a hotspot in RNA research. It has been reported that circRNAs constitute a significant proportion of transcript expression, and some are significantly more abundantly expressed than other transcripts. CircRNAs have regulatory roles in gene expression and critical biological functions in the development of organisms, such as acting as microRNA sponges or as endogenous RNAs and biomarkers. As such, they may have useful functions in the diagnosis and treatment of diseases. CircRNAs have been found to play an important role in the development of several diseases, including atherosclerosis, neurological disorders, diabetes, and cancer. In this paper, we review the status of circRNA research, describe circRNA-related databases and the identification of circRNAs, discuss the role of circRNAs in human diseases such as colon cancer, atherosclerosis, and gastric cancer, and identify remaining research questions related to circRNAs.

scholarly journals Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure

2016 ◽  
Vol 39 (1) ◽  
pp. 205-216 ◽  
Author(s):  
Hong-Jin Wu ◽  
Cheng-Ying Zhang ◽  
Sai Zhang ◽  
Min Chang ◽  
Hong-Yun Wang
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Potential Role ◽  
Expression Patterns ◽  
Heart Tissue ◽  
Circular Rnas ◽  
Global Changes ◽  
Microarray Expression ◽  
Microarray Expression Profile

Background/Aims: Myocardial infarction (MI) is a serious complication of atherosclerosis associated with increasing mortality attributable to heart failure. This study is aimed to assess the global changes in and characteristics of the transcriptome of circular RNAs (circRNAs) in heart tissue during MI induced heart failure (HF). Methods: Using a post-myocardial infarction (MI) model of HF in mice, we applied microarray assay to examine the transcriptome of circRNAs deregulated in the heart during HF. We confirmed the changes in circRNAs by quantitative PCR. Results: We revealed and confirmed a number of circRNAs that were deregulated during HF, which suggests a potential role of circRNAs in HF. Conclusions: The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.

scholarly journals Potential role of HIV-1 Nef and human M6B in HIV-associated neurological disorders

Retrovirology ◽  
2010 ◽  
Vol 7 (S1) ◽  
Author(s):  
Jessica Moetter ◽  
Silke Hoffmann ◽  
Esther Jonas ◽  
Dieter Willbold
Keyword(s):  
Neurological Disorders ◽  
Potential Role ◽  
Hiv 1

scholarly journals Regulatory Role of Circular RNAs and Neurological Disorders

2016 ◽  
Vol 54 (7) ◽  
pp. 5156-5165 ◽  
Author(s):  
Gabriele Floris ◽  
Longbin Zhang ◽  
Paolo Follesa ◽  
Tao Sun
Keyword(s):  
Neurological Disorders ◽  
Regulatory Role ◽  
Circular Rnas

Registry of inherited bleeding disorders in Poland - current status and potential role of the HemoRec database

Haemophilia ◽  
2010 ◽  
Vol 17 (1) ◽  
pp. e189-e195 ◽  
Author(s):  
J. ZDZIARSKA ◽  
K. CHOJNOWSKI ◽  
A. KLUKOWSKA ◽  
M. ŁĘTOWSKA ◽  
A. MITAL ◽  
...  
Keyword(s):  
Potential Role ◽  
Current Status ◽  
Bleeding Disorders

scholarly journals Management of pandemic or large-scale emergencies in Germany with a focus on the current and potential role of university schools of dentistry: Can it help in COVID-19 time?

2020 ◽  
Vol 44 (1) ◽  
Author(s):  
Marcus Schiller ◽  
Marijatta Pilette ◽  
Björn Rahlf ◽  
Constantin von See ◽  
N.-C. Gellrich
Keyword(s):  
Medical Care ◽  
Large Scale ◽  
Potential Role ◽  
Mass Casualty ◽  
Current Status ◽  
Patient Treatment ◽  
Emergency Medical Care ◽  
Emergency Medical ◽  
Available Resources

Abstract Background The study presented here systematically examines the potential involvement of dental, oral and maxillofacial centres (ZMK) in the management of pandemia or in large-scale emergencies. It looks at available material and infrastructural resources and how they can be brought to bear in such incidents or situations. The aim was to gain an initial scientific overview of how ZMK can potentially contribute to the handling of a pandemia or mass casualty (MASCAL) situation in terms of available resources as well as their location within the hospital as a whole and their integration into the existing infrastructure. The study was conducted on the basis of a questionnaire consisting of 70 individual questions, which was sent to all universities in Germany that offer a course of study in dental medicine. The responses were then statistically evaluated. Results The study outlines the current status of ZMK and discusses what could be an important component of emergency medical care in the overall hospital context. Conclusion The involvement of ZMK—with their own resources and existing infrastructural links to the hospital as a whole—could lead to faster and more effective patient treatment in the event of a pandemic or MASCAL situation.

Current Status of the Potential Role of Flavonoids in Neuroprotection

2002 ◽  
pp. 503-525
Author(s):  
Hagen Schroeter ◽  
Jeremy P.E. Spencer ◽  
Catherine Rice-Evans
Keyword(s):  
Potential Role ◽  
Current Status

Therapeutic Potentials of A2B Adenosine Receptor Ligands: Current Status and Perspectives

2019 ◽  
Vol 25 (25) ◽  
pp. 2741-2771 ◽  
Author(s):  
Balakumar Chandrasekaran ◽  
Sara Samarneh ◽  
Abdul Muttaleb Yousef Jaber ◽  
Ghadir Kassab ◽  
Nikhil Agrawal
Keyword(s):  
Potential Role ◽  
Current Status ◽  
Special Focus ◽  
Receptor Ligands ◽  
Drug Candidates ◽  
Inflammatory Conditions ◽  
Adenosine Receptor Ligands ◽  
Subtype Selective ◽  
G Protein Coupled

Background: Adenosine receptors (ARs) are classified as A1, A2A, A2B, and A3 subtypes belong to the superfamily of G-protein coupled receptors (GPCRs). More than 40% of modern medicines act through either activation or inhibition of signaling processes associated with GPCRs. In particular, A2B AR signaling pathways are implicated in asthma, inflammation, cancer, ischemic hyperfusion, diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, and kidney disease. Methods: This article reviews different disease segments wherein A2B AR is implicated and discusses the potential role of subtype-selective A2B AR ligands in the management of such diseases or disorders. All the relevant publications on this topic are reviewed and presented scientifically. Results: This review provides an up-to-date highlight of the recent advances in the development of novel and selective A2B AR ligands and their therapeutic role in treating various disease conditions. A special focus has been given to the therapeutic potentials of selective A2B AR ligands in the management of airway inflammatory conditions and cancer. Conclusions: This systematic review demonstrates the current status and perspectives of A2B AR ligands as therapeutically useful agents that would assist medicinal chemists and pharmacologists in discovering novel and subtype-selective A2B AR ligands as potential drug candidates.

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