scholarly journals Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene

2018 ◽  
Vol 148 (2) ◽  
pp. 204-218 ◽  
Author(s):  
Keietsu Kikuchi ◽  
Daisuke Ihara ◽  
Mamoru Fukuchi ◽  
Hiroki Tanabe ◽  
Yuta Ishibashi ◽  
...  
Keyword(s):  
Synaptic Activity ◽  
Responsive Element ◽  
Arc Gene

scholarly journals Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons

2008 ◽  
Vol 106 (1) ◽  
pp. 316-321 ◽  
Author(s):  
T. Kawashima ◽  
H. Okuno ◽  
M. Nonaka ◽  
A. Adachi-Morishima ◽  
N. Kyo ◽  
...  
Keyword(s):  
Synaptic Activity ◽  
Responsive Element

scholarly journals Synaptic Activity Responsive Element (SARE)

2010 ◽  
Vol 3 (5) ◽  
pp. 443-446 ◽  
Author(s):  
Masatoshi Inoue ◽  
Nan Yagishita-Kyo ◽  
Mio Nonaka ◽  
Takashi Kawashima ◽  
Hiroyuki Okuno ◽  
...  
Keyword(s):  
Synaptic Activity ◽  
Responsive Element

scholarly journals The Neuroplasticity-Associated Arc Gene Is a Direct Transcriptional Target of Early Growth Response (Egr) Transcription Factors

2005 ◽  
Vol 25 (23) ◽  
pp. 10286-10300 ◽  
Author(s):  
Lin Li ◽  
John Carter ◽  
Xiaoguang Gao ◽  
Jennifer Whitehead ◽  
Warren G. Tourtellotte
Keyword(s):  
Transcription Factors ◽  
Synaptic Plasticity ◽  
Learning And Memory ◽  
Growth Response ◽  
Long Term Potentiation ◽  
Early Growth ◽  
Synaptic Activity ◽  
Early Growth Response ◽  
Arc Gene

ABSTRACT Early growth response (Egr) transcription factors (Egr1 to Egr4) are synaptic activity-inducible immediate early genes (IEGs) that regulate some aspects of synaptic plasticity-related to learning and memory, yet the target genes regulated by them are unknown. In particular, Egr1 is essential for persistence of late-phase long-term potentiation (L-LTP), for hippocampus-dependent long-term memory formation, and for reconsolidation of previously established memories. Here, we show that Egr1 and Egr3 directly regulate the plasticity-associated activity-regulated cytoskeletal-related (Arc) gene, a synaptic activity-induced effector molecule which is also required for L-LTP and hippocampus-dependent learning and memory processing. Moreover, Egr1-deficient and Egr3-deficient mice lack Arc protein in a subpopulation of neurons, while mice lacking both Egr1 and Egr3 lack Arc in all neurons. Thus, Egr1 and Egr3 can indirectly modulate synaptic plasticity by directly regulating Arc and the plasticity mechanisms it mediates in recently activated synapses.

scholarly journals Enrichment of Conserved Synaptic Activity-Responsive Element in Neuronal Genes Predicts a Coordinated Response of MEF2, CREB and SRF

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53848 ◽  
Author(s):  
Fernanda M. Rodríguez-Tornos ◽  
Iñigo San Aniceto ◽  
Beatriz Cubelos ◽  
Marta Nieto
Keyword(s):  
Synaptic Activity ◽  
Neuronal Genes ◽  
Responsive Element

scholarly journals The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health

2021 ◽  
Vol 134 (8) ◽  
Author(s):  
Pawel Mozolewski ◽  
Maciej Jeziorek ◽  
Christoph M. Schuster ◽  
Hilmar Bading ◽  
Bess Frost ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brain Function ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Synaptic Activity ◽  
Aging Brain ◽  
Specific Gene ◽  
Neuronal Synapses ◽  
Element Binding Protein ◽  
Responsive Element

ABSTRACT Nuclear Ca2+ has emerged as one of the most potent mediators of the dialogue between neuronal synapses and the nucleus that regulates heterochromatin states, transcription factor activity, nuclear morphology and neuronal gene expression induced by synaptic activity. Recent studies underline the importance of nuclear Ca2+ signaling in long-lasting, activity-induced adaptation and maintenance of proper brain function. Diverse forms of neuroadaptation require transient nuclear Ca2+ signaling and cyclic AMP-responsive element-binding protein (CREB1, referred to here as CREB) as its prime target, which works as a tunable switch to drive and modulate specific gene expression profiles associated with memory, pain, addiction and neuroprotection. Furthermore, a reduction of nuclear Ca2+ levels has been shown to be neurotoxic and a causal factor driving the progression of neurodegenerative disorders, as well as affecting neuronal autophagy. Because of its central role in the brain, deficits in nuclear Ca2+ signaling may underlie a continuous loss of neuroprotection in the aging brain, contributing to the pathophysiology of Alzheimer's disease. In this Review, we discuss the principles of the ‘nuclear calcium hypothesis’ in the context of human brain function and its role in controlling diverse forms of neuroadaptation and neuroprotection. Furthermore, we present the most relevant and promising perspectives for future studies.

Ischemic preconditioning protects the hippocampal CA1 neurons by inhibiting synaptic activity in rat

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S300-S300
Author(s):  
Thomas J Sick ◽  
Ami P Raval ◽  
Isabel Saul ◽  
Kunjan R Dave ◽  
Raul Busto ◽  
...  
Keyword(s):  
Ischemic Preconditioning ◽  
Synaptic Activity ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1
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