scholarly journals The mGluR5 positive allosteric modulator VU0409551 improves synaptic plasticity and memory of a mouse model of Huntington's disease

2018 ◽  
Vol 147 (2) ◽  
pp. 222-239 ◽  
Author(s):  
Juliana G. Doria ◽  
Jessica M. de Souza ◽  
Flavia R. Silva ◽  
Isabella G. Olmo ◽  
Toniana G. Carvalho ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator

The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease

2015 ◽  
Vol 73 ◽  
pp. 163-173 ◽  
Author(s):  
J.G. Doria ◽  
J.M. de Souza ◽  
J.N. Andrade ◽  
H.A. Rodrigues ◽  
I.M. Guimaraes ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator

scholarly journals Neurotrophin-3 restores synaptic plasticity in the striatum of a mouse model of Huntington's disease

2018 ◽  
Vol 24 (4) ◽  
pp. 353-363 ◽  
Author(s):  
Victor G. Gómez-Pineda ◽  
Francisco M. Torres-Cruz ◽  
César I. Vivar-Cortés ◽  
Elizabeth Hernández-Echeagaray
Keyword(s):  
Synaptic Plasticity ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurotrophin 3

scholarly journals Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model

2017 ◽  
Vol 38 (3) ◽  
pp. 544-554 ◽  
Author(s):  
Marja D. Sepers ◽  
Amy Smith-Dijak ◽  
Jeff LeDue ◽  
Karolina Kolodziejczyk ◽  
Ken Mackie ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals Deficit in motor skill learning-dependent synaptic plasticity at motor cortex to Dorso Lateral Striatum synapses in a mouse model of Huntington's disease

2019 ◽  
Author(s):  
Christelle Glangetas ◽  
Pedro Espinosa ◽  
Camilla Bellone
Keyword(s):  
Synaptic Plasticity ◽  
Motor Cortex ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Motor Skill ◽  
Dynamic Change ◽  
Skill Learning ◽  
Lateral Part ◽  
Motor Skill Learning

Huntington's disease (HD) is a neurodegenerative disease notably characterized by progressive motor symptoms. Although the loss of Medium Spiny Neurons (MSNs) in the striatum has been associated with motor deficits, premanifest patients already present cognitive deficiencies and show early signs of motor disabilities. Here in a YAC128 HD mouse model, we identified impairment in motor skill learning at the age of 11 to 14 weeks. Using optogenetic stimulation, we found that excitatory synaptic transmission from motor cortex to MSNs located in the Dorso Lateral part of the Striatum (DLS) is altered. Using single pellet reaching task, we observed that while motor skill learning is accompanied by a dynamic change in AMPA/NMDA ratio in wild type mice, this form of synaptic plasticity does not occur in YAC128 mice. This study not only proposes new meaningful insight the synaptopathic mechanisms of HD, but also highlights that deficit in motor skill learning dependent synaptic plasticity at motor cortex to DLS synapses represents an early biomarker for Huntington's disease.

scholarly journals Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease

2006 ◽  
Vol 15 (10) ◽  
pp. 1690-1703 ◽  
Author(s):  
Austen J. Milnerwood ◽  
Damian M. Cummings ◽  
Glenn M. Dallérac ◽  
Jacki Y. Brown ◽  
Sarat C. Vatsavayai ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Early Development

Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity

2016 ◽  
Vol 95 ◽  
pp. 22-34 ◽  
Author(s):  
Marta Anglada-Huguet ◽  
Laura Vidal-Sancho ◽  
Albert Giralt ◽  
Gerardo García-Díaz Barriga ◽  
Xavier Xifró ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Mouse Model ◽  
Prostaglandin E2 ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Memory Decline
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