scholarly journals The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis

2018 ◽  
Vol 146 (3) ◽  
pp. 251-268 ◽  
Author(s):  
Anne Jacob ◽  
Hannah M. Wüst ◽  
Johannes M. Thalhammer ◽  
Franziska Fröb ◽  
Melanie Küspert ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Homeobox Protein ◽  
Direct Target

GHF-1, a Tissue-Specific Transcription Factor, is a Homeobox Protein

1989 ◽  
pp. 90-109
Author(s):  
José-Luis Castrillo ◽  
Lars E. Theill ◽  
Mordechai Bodner ◽  
Michael Karin
Keyword(s):  
Transcription Factor ◽  
Tissue Specific ◽  
Specific Transcription Factor ◽  
Homeobox Protein

scholarly journals DUX4 Signalling in the Pathogenesis of Facioscapulohumeral Muscular Dystrophy

2020 ◽  
Vol 21 (3) ◽  
pp. 729 ◽  
Author(s):  
Kenji Rowel Q. Lim ◽  
Quynh Nguyen ◽  
Toshifumi Yokota
Keyword(s):  
Skeletal Muscle ◽  
Cell Death ◽  
Transcription Factor ◽  
Muscular Dystrophy ◽  
Embryonic Development ◽  
Disease Onset ◽  
Facioscapulohumeral Muscular Dystrophy ◽  
Signalling Pathways ◽  
Progressive Muscle Weakness ◽  
Homeobox Protein

Facioscapulohumeral muscular dystrophy (FSHD) is a disabling inherited muscular disorder characterized by asymmetric, progressive muscle weakness and degeneration. Patients display widely variable disease onset and severity, and sometimes present with extra-muscular symptoms. There is a consensus that FSHD is caused by the aberrant production of the double homeobox protein 4 (DUX4) transcription factor in skeletal muscle. DUX4 is normally expressed during early embryonic development, and is then effectively silenced in all tissues except the testis and thymus. Its reactivation in skeletal muscle disrupts numerous signalling pathways that mostly converge on cell death. Here, we review studies on DUX4-affected pathways in skeletal muscle and provide insights into how understanding these could help explain the unique pathogenesis of FSHD.

scholarly journals An aquaporin gene as a direct target of the Zic1 transcription factor

2008 ◽  
Vol 319 (2) ◽  
pp. 579
Author(s):  
E.J. Cornish ◽  
Sabah M. Hassan ◽  
Christa Merzdorf
Keyword(s):  
Transcription Factor ◽  
Aquaporin Gene ◽  
Direct Target

scholarly journals Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG

Oncogene ◽  
2011 ◽  
Vol 30 (17) ◽  
pp. 2044-2056 ◽  
Author(s):  
L H Mochmann ◽  
J Bock ◽  
J Ortiz-Tánchez ◽  
C Schlee ◽  
A Bohne ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Genome Wide ◽  
Direct Target ◽  
Ets Transcription Factor ◽  
Canonical Wnt

scholarly journals Integrative analysis of transcriptomic and clinical data uncovers the tumor suppressive activity of MITF in prostate cancer

2018 ◽  
Author(s):  
Lorea Valcarcel-Jimenez ◽  
Alice Macchia ◽  
Natalia Martín-Martín ◽  
Ana Rosa Cortazar ◽  
Ariane Schaub-Clerigué ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Transcription Factor ◽  
Clinical Data ◽  
Cancer Biology ◽  
Human Cancer ◽  
Suppressive Activity ◽  
Proof Of Concept ◽  
Clinical Annotation ◽  
Transcriptomics Data ◽  
Direct Target

AbstractThe dysregulation of gene expression is an enabling hallmark of cancer. Computational analysis of transcriptomics data from human cancer specimens, complemented with exhaustive clinical annotation, provides an opportunity to identify core regulators of the tumorigenic process. Here we exploit well-annotated clinical datasets of prostate cancer for the discovery of transcriptional regulators relevant to prostate cancer. Following this rationale, we identify Microphthalmia-associated transcription factor (MITF) as a prostate tumor suppressor among a subset of transcription factors. Importantly, we further interrogate transcriptomics and clinical data to refine MITF perturbation-based empirical assays and unveil Crystallin Alpha B (CRYAB) as an unprecedented direct target of the transcription factor that is, at least in part, responsible for its tumor suppressive activity in prostate cancer. This evidence was supported by the enhanced prognostic potential of a signature based on the concomitant alteration of MITF and CRYAB in prostate cancer patients. In sum, our study provides proof-of-concept evidence of the potential of the bioinformatics screen of publicly available cancer patient databases as discovery platforms, and demonstrates that the MITF-CRYAB axis controls prostate cancer biology.

scholarly journals Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function

FEBS Journal ◽  
2022 ◽  
Author(s):  
Tomislav Kokotović ◽  
Ewelina M. Lenartowicz ◽  
Michiel Langeslag ◽  
Cosmin I. Ciotu ◽  
Christopher W. Fell ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Homeobox Protein

scholarly journals Cistrome-GO: a web server for functional enrichment analysis of transcription factor ChIP-seq peaks

2019 ◽  
Vol 47 (W1) ◽  
pp. W206-W211 ◽  
Author(s):  
Shaojuan Li ◽  
Changxin Wan ◽  
Rongbin Zheng ◽  
Jingyu Fan ◽  
Xin Dong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Regulation ◽  
Transcription Factor ◽  
Target Genes ◽  
Enrichment Analysis ◽  
Functional Enrichment Analysis ◽  
Functional Enrichment ◽  
Differential Gene ◽  
Direct Target ◽  
Human And Mouse

AbstractCharacterizing the ontologies of genes directly regulated by a transcription factor (TF), can help to elucidate the TF’s biological role. Previously, we developed a widely used method, BETA, to integrate TF ChIP-seq peaks with differential gene expression (DGE) data to infer direct target genes. Here, we provide Cistrome-GO, a website implementation of this method with enhanced features to conduct ontology analyses of gene regulation by TFs in human and mouse. Cistrome-GO has two working modes: solo mode for ChIP-seq peak analysis; and ensemble mode, which integrates ChIP-seq peaks with DGE data. Cistrome-GO is freely available at http://go.cistrome.org/.

beta3-tubulin is directly repressed by the engrailed protein in Drosophila

Development ◽  
1997 ◽  
Vol 124 (13) ◽  
pp. 2527-2536 ◽  
Author(s):  
N. Serrano ◽  
H.W. Brock ◽  
F. Maschat
Keyword(s):  
Transcription Factor ◽  
Binding Sites ◽  
Transgenic Line ◽  
Target Genes ◽  
Regulatory Protein ◽  
Polytene Chromosomes ◽  
First Intron ◽  
Direct Target

In Drosophila, Engrailed is a nuclear regulatory protein with essential roles during embryonic development. Although Engrailed is a transcription factor, little progress has been achieved in identifying its target genes. We report here the identification of an effector gene, the beta3-tubulin gene, as a direct target of Engrailed. The cytological location of beta3-tubulin, 60C, is a strong site of Engrailed binding on polytene chromosomes. Immunostaining analysis of a transgenic line containing a P[beta3-tubulin-lacZ] construct shows an additional site of Engrailed binding at the location of the transgene. Molecular analysis allowed identification of several Engrailed binding sites, both in vitro and in vivo, within the first intron of the beta3-tubulin locus. Engrailed binding sites identified in vitro are active in larvae. Furthermore, expression of beta3-tubulin is derepressed in the ectoderm of engrailed mutant embryos. Repression of beta3-tubulin by Engrailed is also obtained when Engrailed is ectopically expressed in embryonic mesoderm. Finally, two different sets of Engrailed binding sites are shown to be involved in the early and late regulation of beta3-tubulin by Engrailed during embryogenesis.

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