scholarly journals Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease

2017 ◽  
Vol 141 (5) ◽  
pp. 766-782 ◽  
Author(s):  
Muhammet Ay ◽  
Jie Luo ◽  
Monica Langley ◽  
Huajun Jin ◽  
Vellareddy Anantharam ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Mitochondrial Dysfunction ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Molecular Mechanisms ◽  
Protective Effects ◽  
Transgenic Mouse Models ◽  
Dopaminergic Neurodegeneration

2.018 Neuropathology of conditional alpha-synuclein transgenic mouse models of Parkinson's disease

2007 ◽  
Vol 13 ◽  
pp. S90
Author(s):  
S. Nuber ◽  
E. Petrasch-Parwez ◽  
B. Winner ◽  
J. Winkler ◽  
S. von Hörsten ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Alpha Synuclein ◽  
Transgenic Mouse Models

2.304 Neuropathology of conditional alpha-synuclein transgenic mouse models of Parkinson's disease

2007 ◽  
Vol 13 ◽  
pp. S122
Author(s):  
S. Nuber ◽  
E. Petrasch-Parwez ◽  
B. Winner ◽  
J. Winkler ◽  
S. von Hörsten ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Alpha Synuclein ◽  
Transgenic Mouse Models

Comparable processing ofβ-lactoglobulin pre-mRNA in cell culture and transgenic mouse models

1996 ◽  
Vol 252 (4) ◽  
pp. 465-469
Author(s):  
G. Donofrio ◽  
A. J. Clark ◽  
C. B. A. Whitelaw ◽  
G. Donofrio ◽  
E. Bignetti
Keyword(s):  
Cell Culture ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Transgenic Mouse Models

scholarly journals Mitochondrial Fusion/Fission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Daniela M. Arduíno ◽  
A. Raquel Esteves ◽  
Sandra M. Cardoso
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dysfunction ◽  
Molecular Basis ◽  
Molecular Mechanisms ◽  
Mitochondrial Dynamics ◽  
Growing Body ◽  
Parkinsonian Disorders ◽  
Mitochondrial Trafficking

Understanding the molecular basis of Parkinson's disease (PD) has proven to be a major challenge in the field of neurodegenerative diseases. Although several hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of PD, a growing body of evidence has highlighted the role of mitochondrial dysfunction and the disruption of the mechanisms of mitochondrial dynamics in PD and other parkinsonian disorders. In this paper, we comment on the recent advances in how changes in the mitochondrial function and mitochondrial dynamics (fusion/fission, transport, and clearance) contribute to neurodegeneration, specifically focusing on PD. We also evaluate the current controversies in those issues and discuss the role of fusion/fission dynamics in the mitochondrial lifecycle and maintenance. We propose that cellular demise and neurodegeneration in PD are due to the interplay between mitochondrial dysfunction, mitochondrial trafficking disruption, and impaired autophagic clearance.

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