Neuroprotective effects of antibodies on retinal ganglion cells in an adolescent retina organ culture

2016 ◽  
Vol 139 (2) ◽  
pp. 256-269 ◽  
Author(s):  
Katharina Bell ◽  
Corina Wilding ◽  
Sebastian Funke ◽  
Natarajan Perumal ◽  
Sabine Beck ◽  
...  
Keyword(s):  
Organ Culture ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Neuroprotective Effects

Neuroprotective Effects of C-Type Natriuretic Peptide on Rat Retinal Ganglion Cells

2010 ◽  
Vol 51 (7) ◽  
pp. 3544 ◽  
Author(s):  
Jia Ma ◽  
Wenhan Yu ◽  
Yun Wang ◽  
Guiqun Cao ◽  
Suping Cai ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Natriuretic Peptide ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Neuroprotective Effects

scholarly journals Brazilian Green Propolis Protects against Retinal Damage In Vitro and In Vivo

2006 ◽  
Vol 3 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Yuta Inokuchi ◽  
Masamitsu Shimazawa ◽  
Yoshimi Nakajima ◽  
Shinsuke Suemori ◽  
Satoshi Mishima ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Water Soluble ◽  
Retinal Damage ◽  
Retinal Ganglion ◽  
Neuroprotective Effects ◽  
Brazilian Green Propolis

Propolis, a honeybee product, has gained popularity as a food and alternative medicine. Its constituents have been shown to exert pharmacological (anticancer, antimicrobial and anti-inflammatory) effects. We investigated whether Brazilian green propolis exerts neuroprotective effects in the retinain vitroand/orin vivo.In vitro, retinal damage was induced by 24 h hydrogen peroxide (H2O2) exposure, and cell viability was measured by Hoechst 33342 and YO-PRO-1 staining or by a resazurin–reduction assay. Propolis inhibited the neurotoxicity and apoptosis induced in cultured retinal ganglion cells (RGC-5, a rat ganglion cell line transformed using E1A virus) by 24 h H2O2 exposure. Propolis also inhibited the neurotoxicity induced in RGC-5 cultures by staurosporine. Regarding the possible underlying mechanism, in pig retina homogenates propolis protected against oxidative stress (lipid peroxidation), as also did trolox (water-soluble vitamin E). In micein vivo, propolis (100 mg kg−1; intraperitoneally administered four times) reduced the retinal damage (decrease in retinal ganglion cells and in thickness of inner plexiform layer) induced by intravitrealin vivo N-methyl-d-aspartate injection. These findings indicate that Brazilian green propolis has neuroprotective effects against retinal damage bothin vitroandin vivo, and that a propolis-induced inhibition of oxidative stress may be partly responsible for these neuroprotective effects.

Neuroprotective Effects of Nipradilol on Purified Cultured Retinal Ganglion Cells

2002 ◽  
Vol 11 (3) ◽  
pp. 231-238 ◽  
Author(s):  
Kenji Kashiwagi ◽  
Yoko Iizuka ◽  
Shigeo Tsukahara
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Neuroprotective Effects

Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells

2009 ◽  
Vol 1251 ◽  
pp. 269-275 ◽  
Author(s):  
Masamitsu Shimazawa ◽  
Yoshimi Nakajima ◽  
Yukihiko Mashima ◽  
Hideaki Hara
Keyword(s):  
Oxidative Stress ◽  
Docosahexaenoic Acid ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Neuroprotective Effects

Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells

2005 ◽  
Vol 1050 (1-2) ◽  
pp. 15-26 ◽  
Author(s):  
Makiko Yamasaki ◽  
Hiromu K. Mishima ◽  
Hidetoshi Yamashita ◽  
Kenji Kashiwagi ◽  
Kazuhiko Murata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Neuroprotective Effects ◽  
Nitric Oxide Toxicity

Hypothermia protects retinal ganglion cells against hypoxia‐induced cell death in a retina organ culture model

2019 ◽  
Vol 47 (8) ◽  
pp. 1043-1054 ◽  
Author(s):  
Patricia Klemm ◽  
José Hurst ◽  
Matthias Dias Blak ◽  
Thoralf Herrmann ◽  
Marion Melchinger ◽  
...  
Keyword(s):  
Cell Death ◽  
Organ Culture ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Culture Model
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