scholarly journals Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin-7

2016 ◽  
Vol 140 (6) ◽  
pp. 889-902 ◽  
Author(s):  
Megan B. Miller ◽  
Yan Yan ◽  
Yi Wu ◽  
Bing Hao ◽  
Richard E. Mains ◽  
...  
Keyword(s):  
Alternate Promoter ◽  
Promoter Usage

The mouse Na+-K+-ATPase γ-subunit gene (Fxyd2) encodes three developmentally regulated transcripts

2001 ◽  
Vol 6 (3) ◽  
pp. 129-135 ◽  
Author(s):  
D. HOLSTEAD JONES ◽  
MICHAEL C. GOLDING ◽  
KEVIN J. BARR ◽  
GUO-HUA FONG ◽  
GERALD M. KIDDER
Keyword(s):  
Expression Patterns ◽  
Subunit Gene ◽  
Differential Splicing ◽  
Cloning And Sequencing ◽  
Developmentally Regulated ◽  
Specific Expression ◽  
Catalytic Function ◽  
Γ Subunit ◽  
Alternate Promoter ◽  
Promoter Usage

The Na+-K+-ATPase is understood to function as a hetero-oligomer of α- and β-subunits, but a third subunit, γ, has been proposed to influence the enzyme’s catalytic function. Recently, two variants of the γ-subunit have been described in kidney, raising the possibility of multiple γ-subunits with diverse functions. We now report the cloning and sequencing of the mouse γ-subunit gene ( Fxyd2). Analysis of the structure of the gene shows that it encodes three mRNAs that have distinct NH2-terminal (extracellular) encoding sequences but common transmembrane and COOH-terminal-encoding sequences resulting from differential splicing and, probably, alternate promoter usage. The three mRNAs have tissue-specific expression patterns. The existence of three different extracellular domains of the γ-variants and how they may interact with the sodium pump to alter its cation transport properties must now be taken into account for future understanding of the modulation of the Na+-K+-ATPase by its γ-subunit.

scholarly journals Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Malaney R. O’Connell ◽  
Shubhashish Sarkar ◽  
Gurinder K. Luthra ◽  
Yoshinaga Okugawa ◽  
Yuji Toiyama ◽  
...  
Keyword(s):  
Human Colon ◽  
Clinical Implications ◽  
Epigenetic Changes ◽  
Colon Cancers ◽  
Alternate Promoter ◽  
Promoter Usage

Abstract 2096: Resistance to APTO-253 caused by internal deletion and alternate promoter usage of the MYC gene in malignant B cells

2019 ◽  
Author(s):  
Andrea Local ◽  
Cheng-Yu Tsai ◽  
Hongying Zhang ◽  
Susan Sheng ◽  
Khalid Benbatoul ◽  
...  
Keyword(s):  
B Cells ◽  
Internal Deletion ◽  
Myc Gene ◽  
Alternate Promoter ◽  
Promoter Usage

Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage

Cell ◽  
1990 ◽  
Vol 62 (6) ◽  
pp. 1105-1114 ◽  
Author(s):  
Peter D. Rathjen ◽  
Sara Toth ◽  
Anthony Willis ◽  
John K. Heath ◽  
Austin G. Smith
Keyword(s):  
Inhibiting Activity ◽  
Alternate Promoter ◽  
Promoter Usage

scholarly journals Real-Time Visualization of Human Prolactin Alternate Promoter Usage in Vivo Using a Double-Transgenic Rat Model

2009 ◽  
Vol 23 (4) ◽  
pp. 529-538 ◽  
Author(s):  
Sabrina Semprini ◽  
Sonke Friedrichsen ◽  
Claire V. Harper ◽  
Judith R. McNeilly ◽  
Antony D. Adamson ◽  
...  
Keyword(s):  
Real Time ◽  
Rat Model ◽  
Transgenic Rat ◽  
Human Prolactin ◽  
Real Time Visualization ◽  
Alternate Promoter ◽  
Promoter Usage ◽  
Transgenic Rat Model

HIF-1α induces MXI1 by alternate promoter usage in human neuroblastoma cells

2009 ◽  
Vol 315 (11) ◽  
pp. 1924-1936 ◽  
Author(s):  
Tobias Löfstedt ◽  
Erik Fredlund ◽  
Rosa Noguera ◽  
Samuel Navarro ◽  
Linda Holmquist-Mengelbier ◽  
...  
Keyword(s):  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Alternate Promoter ◽  
Promoter Usage
Sign in / Sign up

Export Citation Format

Share Document