scholarly journals Analysis of the amyloid precursor protein role in neuritogenesis reveals a biphasic SH-SY5Y neuronal cell differentiation model

2015 ◽  
Vol 134 (2) ◽  
pp. 288-301 ◽  
Author(s):  
Joana Fernandes da Rocha ◽  
Odete A. B. da Cruz e Silva ◽  
Sandra Isabel Vieira
Keyword(s):  
Cell Differentiation ◽  
Amyloid Precursor Protein ◽  
Neuronal Cell ◽  
Precursor Protein ◽  
Neuronal Cell Differentiation ◽  
Differentiation Model ◽  
Cell Differentiation Model

G-lymphatic, vascular and immune pathways for Aβ clearance cascade and therapeutic targets for Alzheimer’s disease

2020 ◽  
Vol 23 ◽  
Author(s):  
Saurav Chakraborty ◽  
Jyothsna ThimmaReddygari ◽  
Divakar Selvaraj
Keyword(s):  
Alzheimer Disease ◽  
Amyloid Precursor Protein ◽  
Amyloid Beta ◽  
Complement System ◽  
Therapeutic Targets ◽  
Neuronal Cell ◽  
Precursor Protein ◽  
Amyloid Beta Peptide ◽  
Beta Peptide ◽  
Immune Pathways

The Alzheimer disease is a age related neurodegenerative disease. The factors causing alzheimer disease are numerous. Research on humans and rodent models predicted various causative factors involved in Alzheimer disease progression. Among them, neuroinflammation, oxidative stress and apoptosis play a major role because of accumulation of extracellular amyloid beta peptides. Here, the clearance of amyloid beta peptide plays a major role because of the imbalance in the production and clearance of the amyloid beta peptide. Additionally, neuroinflammation by microglia, astrocytes, cytokines, chemokines and the complement system also have a major role in Alzheimer disease. The physiological clearance pathways involved in amyloid beta peptide are glymphatic, vascular and immune pathways. Amyloid precursor protein, low density lipoprotein receptor-related protein 1, receptor for advanced glycation end product, apolipoprotein E, clusterin, aquaporin 4, auto-antibodies, complement system, cytokines and microglia are involved in amyloid beta peptide clearance pathways across the blood brain barrier. The plaque formation in the brain by alternative splicing of amyloid precursor protein and production of misfolded protein results in amyloid beta agglomeration. This insoluble amyloid beta leads to neurodegenerative cascade and neuronal cell death occurs. Studies had shown disturbed sleep may be a risk factor for dementia and cognitive decline. In this review, the therapeutic targets for alzheimer disease via focussing on pathways for amyloid beta clearance are discussed.

scholarly journals Neuronal cell differentiation of mesenchymal stem cells originating from canine amniotic fluid

Human Cell ◽  
2013 ◽  
Vol 27 (2) ◽  
pp. 51-58 ◽  
Author(s):  
Eun Young Kim ◽  
Kyung-Bon Lee ◽  
Jung Yu ◽  
Ji Hye Lee ◽  
Keun Jung Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Differentiation ◽  
Amniotic Fluid ◽  
Neuronal Cell ◽  
Neuronal Cell Differentiation

Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

2003 ◽  
Vol 84 (4) ◽  
pp. 864-877 ◽  
Author(s):  
Yuichi Hashimoto ◽  
Osahiko Tsuji ◽  
Takako Niikura ◽  
Yohichi Yamagishi ◽  
Miho Ishizaka ◽  
...  
Keyword(s):  
Cell Death ◽  
Amyloid Precursor Protein ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Precursor Protein

Proteolytic processing and cell biological functions of the amyloid precursor protein

2000 ◽  
Vol 113 (11) ◽  
pp. 1857-1870 ◽  
Author(s):  
B. De Strooper ◽  
W. Annaert
Keyword(s):  
Amyloid Precursor Protein ◽  
Stress Responses ◽  
Neuronal Cell ◽  
Principal Component ◽  
Proteolytic Processing ◽  
Cholesterol Homeostasis ◽  
Precursor Protein ◽  
Axonal Elongation ◽  
Beta Peptide ◽  
Complex Protein

Recent research has identified some key players involved in the proteolytic processing of amyloid precursor protein (APP) to amyloid beta-peptide, the principal component of the amyloid plaques in Alzheimer patients. Interesting parallels exists with the proteolysis of other proteins involved in cell differentiation, cholesterol homeostasis and stress responses. Since the cytoplasmic domain of APP is anchored to a complex protein network that might function in axonal elongation, dendritic arborisation and neuronal cell migration, the proteolysis of APP might be critically involved in intracellular signalling events.

scholarly journals The Amyloid Precursor Protein Represses Expression of Acetylcholinesterase in Neuronal Cell Lines

2013 ◽  
Vol 288 (36) ◽  
pp. 26039-26051 ◽  
Author(s):  
David A. Hicks ◽  
Natalia Z. Makova ◽  
Mallory Gough ◽  
Edward T. Parkin ◽  
Natalia N. Nalivaeva ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Cell Lines ◽  
Neuronal Cell ◽  
Precursor Protein ◽  
Neuronal Cell Lines

scholarly journals PEDOT doped with algal, mammalian and synthetic dopants: polymer properties, protein and cell interactions, and influence of electrical stimulation on neuronal cell differentiation

2018 ◽  
Vol 6 (5) ◽  
pp. 1250-1261 ◽  
Author(s):  
P. J. Molino ◽  
L. Garcia ◽  
E. M. Stewart ◽  
M. Lamaze ◽  
B. Zhang ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Cell Differentiation ◽  
Neuronal Cells ◽  
Neuronal Cell ◽  
Cell Interactions ◽  
Polymer Properties ◽  
Neuronal Cell Differentiation

PEDOT films were electrochemically polymerised with synthetic and biological dopants, characterised, and their interactions with proteins and neuronal cells investigated.

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