scholarly journals Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways

2015 ◽  
Vol 133 (5) ◽  
pp. 700-707 ◽  
Author(s):  
Rania M. Abdelsalam ◽  
Marwa M. Safar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Signaling Pathways ◽  
Disease Model ◽  
Neuroprotective Effects

scholarly journals Exercise exerts neuroprotective effects on Parkinson's disease model of rats

2010 ◽  
Vol 1310 ◽  
pp. 200-207 ◽  
Author(s):  
Naoki Tajiri ◽  
Takao Yasuhara ◽  
Tetsuro Shingo ◽  
Akihiko Kondo ◽  
Wenji Yuan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects

Elucidating the Neuroprotective Role of Formulated Camel α-Lactalbumin–Oleic Acid Complex by Curating the SIRT1 Pathway in Parkinson’s Disease Model

2020 ◽  
Vol 11 (24) ◽  
pp. 4416-4425
Author(s):  
Saba Ubaid ◽  
Mohammad Rumman ◽  
Babita Singh ◽  
Mohd. Sohail Akhtar ◽  
Abbas A. Mahdi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Oleic Acid ◽  
Disease Model ◽  
Acid Complex

Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating iron

2015 ◽  
Vol 49 (9) ◽  
pp. 1069-1080 ◽  
Author(s):  
Y.-Q. Wang ◽  
M.-Y. Wang ◽  
X.-R. Fu ◽  
Peng-Yu ◽  
G.-F. Gao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects

scholarly journals Neuroprotective Effects of Bak Foong Pill in 1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-Induced Parkinson's Disease Model Mice

2004 ◽  
Vol 27 (8) ◽  
pp. 1245-1250 ◽  
Author(s):  
Bin Liu ◽  
Jun Xia Xie ◽  
Dewi Kenneth Rowlands ◽  
Yu Lin Gou ◽  
Ching Cheong Leung ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects

Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder - Parkinson’s Disease

2020 ◽  
Vol 21 ◽  
Author(s):  
Bairong Shen ◽  
Rajeev K. Singla ◽  
Tanya Agarwal ◽  
He Xuefei
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural Products ◽  
Dopaminergic Neurons ◽  
Symptomatic Treatment ◽  
Neuroprotective Effects ◽  
Chronic Disorder ◽  
System Disorder ◽  
Pro Inflammatory Cytokines

: Parkinson’s disease is one of the most common adult-onset, a chronic disorder involving neurodegeneration, pro-gressively leading to deprivation of dopaminergic neurons in substantia nigra, causing a subsequent reduction of dopa-mine levels in the striatum resulting in tremor, myotonia, and dyskinesia. Genetics and environmental factors are believed to be responsible for the onset of Parkinson’s disease. The exact pathogenesis of Parkinson's dis-ease is quite complicated and the present anti-Parkinson's disease treatments appear to be clinically insufficient. Comprehensive researches have demonstrated the use of natural products such as ginseng, curcumin, ashwa-gandha, baicalein, etc. for the symptomatic treatment of this disease. The neuroprotective effects exhibited by these natural products are mainly due to their ability to increase dopamine levels in the striatum, manage oxidative stress, mitochondrial dysfunction, glutathione levels, clear the aggregation of α-synuclein, induce the autophagy and de-crease the pro-inflammatory cytokines and lipid peroxidation. This paper reviews various natural product studies conducted by the scientists to establish the role of natural products (both metabolite extracts as well as pure metabolites) as adjunctive neuroprotective agents.

scholarly journals Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Hemant Kumar ◽  
In-Su Kim ◽  
Sandeep Vasant More ◽  
Byung-Wook Kim ◽  
Young-Yil Bahk ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Neurons ◽  
Disease Model ◽  
Motor Impairment ◽  
Protective Effects ◽  
Dopamine Depletion ◽  
Active Constituent ◽  
Neuroprotective Effects ◽  
Phenolic Glucoside

Gastrodia elata(GE) Blume is one of the most important traditional plants in Oriental countries and has been used for centuries to improve various conditions. The phenolic glucoside gastrodin is an active constituent of GE. The aim of this study was to investigate the neuroprotective role of gastrodin in 1-methyl-4-phenylpyridinium (MPP+)/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP) induced human dopaminergic SH-SY5Y cells and mouse model of Parkinson’s disease (PD), respectively. Gastrodin significantly and dose dependently protected dopaminergic neurons against neurotoxicity through regulating free radicals, Bax/Bcl-2 mRNA, caspase-3, and cleaved poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells stressed with MPP+. Gastrodin also showed neuroprotective effects in the subchronic MPTP mouse PD model by ameliorating bradykinesia and motor impairment in the pole and rotarod tests, respectively. Consistent with this finding, gastrodin prevented dopamine depletion and reduced reactive astrogliosis caused by MPTP as assessed by immunohistochemistry and immunoblotting in the substantiae nigrae and striatata of mice. Moreover, gastrodin was also effective in preventing neuronal apoptosis by attenuating antioxidant and antiapoptotic activities in these brain areas. These results strongly suggest that gastrodin has protective effects in experimental PD models and that it may be developed as a clinical candidate to ameliorate PD symptoms.

Neuroprotective effects of increasing levels of HSP70 against neuroinflammation in Parkinson's disease model by inhibition of NF-κB and STAT3

Life Sciences ◽  
2019 ◽  
Vol 234 ◽  
pp. 116747 ◽  
Author(s):  
Haining Li ◽  
Juan Yang ◽  
Yanbai Wang ◽  
Qiang Liu ◽  
Jiang Cheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects
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