scholarly journals Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2

2014 ◽  
Vol 130 (6) ◽  
pp. 748-758 ◽  
Author(s):  
Nurgul Carkaci-Salli ◽  
Ugur Salli ◽  
Izel Tekin ◽  
Jeremy A. Hengst ◽  
Moe K. Zhao ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Functional Characterization ◽  
Tryptophan Hydroxylase 2

scholarly journals Functional characterization of the neuron-restrictive silencer element in the human tryptophan hydroxylase 2 gene expression

2017 ◽  
Vol 142 (6) ◽  
pp. 827-840 ◽  
Author(s):  
Yukino Nawa ◽  
Hanae Kaneko ◽  
Masayuki Oda ◽  
Masaaki Tsubonoya ◽  
Tomoko Hiroi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tryptophan Hydroxylase ◽  
Functional Characterization ◽  
Tryptophan Hydroxylase 2 ◽  
Silencer Element

scholarly journals Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2

2006 ◽  
Vol 100 (6) ◽  
pp. 1648-1657 ◽  
Author(s):  
Ingeborg Winge ◽  
Jeffrey A. McKinney ◽  
Per M. Knappskog ◽  
Jan Haavik
Keyword(s):  
Tryptophan Hydroxylase ◽  
Wild Type ◽  
Tryptophan Hydroxylase 2 ◽  
Mutant Forms

Characterization of a Functional Promoter Polymorphism of the Human Tryptophan Hydroxylase 2 Gene in Serotonergic Raphe Neurons

2007 ◽  
Vol 62 (11) ◽  
pp. 1288-1294 ◽  
Author(s):  
Kathrin Scheuch ◽  
Marion Lautenschlager ◽  
Maik Grohmann ◽  
Silke Stahlberg ◽  
Julia Kirchheiner ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Promoter Polymorphism ◽  
Tryptophan Hydroxylase 2 ◽  
Raphe Neurons

Functional characterization of human brown adipose tissue metabolism

2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Functional Characterization ◽  
Human Infants ◽  
Positron Emission ◽  
Brown Adipose ◽  
Treatment Of Obesity ◽  
And Function

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

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