scholarly journals ser31 tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion

2014 ◽  
Vol 129 (3) ◽  
pp. 548-558 ◽  
Author(s):  
Michael F. Salvatore
Keyword(s):  
Tyrosine Hydroxylase ◽  
Nigrostriatal Pathway ◽  
Tyrosine Hydroxylase Phosphorylation

scholarly journals Effect of barodenervation on tyrosine hydroxylase phosphorylation in rat brain following hypotension

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Hanafi Damanhuri ◽  
Larisa Bobrovskaya ◽  
Peter Dunkley ◽  
Ann Goodchild
Keyword(s):  
Tyrosine Hydroxylase ◽  
Rat Brain ◽  
Tyrosine Hydroxylase Phosphorylation

Pyrethroid and organophosphate insecticide exposure in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease: an immunohistochemical analysis of tyrosine hydroxylase and glial fibrillary acidic protein in dorsolateral striatum

2009 ◽  
Vol 25 (1) ◽  
pp. 25-39 ◽  
Author(s):  
CA Dodd ◽  
BG Klein
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Tyrosine Hydroxylase ◽  
Mouse Model ◽  
Glial Fibrillary Acidic Protein ◽  
Immunohistochemical Analysis ◽  
Acidic Protein ◽  
Nigrostriatal Pathway ◽  
Organophosphate Insecticide ◽  
Nigrostriatal Degeneration

The pyrethroid insecticide permethrin and the organophosphate insecticide chlorpyrifos can experimentally produce Parkinson’s disease (PD)-associated changes in the dopaminergic nigrostriatal pathway, short of frank degeneration, although at doses considerably higher than from a likely environmental exposure. The ability of permethrin (200 mg/kg), chlorpyrifos (50 mg/kg), or combined permethrin + chlorpyrifos to facilitate nigrostriatal damage in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (30 mg/kg) C57BL/6 mouse model of PD was investigated in three separate experiments. Tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP) immunohistochemistry assessed nigrostriatal degeneration or nigrostriatal damage more subtle than frank degeneration. Four fields in the dorsolateral caudate-putamen were examined at two rostrocaudal locations. The dopaminergic neurotoxin MPTP decreased striatal TH immunopositive neuropil and increased GFAP immunopositive neuropil. Neither permethrin nor chlorpyrifos, alone or in combination, altered the effects of MPTP upon TH or GFAP immunostaining. Permethrin alone increased striatal GFAP immunopositive neuropil but not when combined with chlorpyrifos treatment. Therefore, combined administration of the two insecticides appeared to protect against an increase in a neuropathological indicator of striatal damage seen with permethrin treatment alone. Differences compared with analysis of entire striatum emphasize the value of varying the topographic focus used to assess nigrostriatal degeneration in studies of insecticides in PD.

Tyrosine hydroxylase phosphorylation: regulation and consequences

2004 ◽  
Vol 91 (5) ◽  
pp. 1025-1043 ◽  
Author(s):  
Peter R. Dunkley ◽  
Larisa Bobrovskaya ◽  
Mark E. Graham ◽  
Ellak I. Von Nagy-Felsobuki ◽  
Phillip W. Dickson
Keyword(s):  
Tyrosine Hydroxylase ◽  
Tyrosine Hydroxylase Phosphorylation

scholarly journals Enhancement of Tyrosine Hydroxylase Phosphorylation and Activity by Glial Cell Line-derived Neurotrophic Factor

2003 ◽  
Vol 279 (3) ◽  
pp. 2182-2191 ◽  
Author(s):  
Nobuhide Kobori ◽  
Jack C. Waymire ◽  
John W. Haycock ◽  
Guy L. Clifton ◽  
Pramod K. Dash
Keyword(s):  
Tyrosine Hydroxylase ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Tyrosine Hydroxylase Phosphorylation

scholarly journals Tyrosine Hydroxylase Phosphorylation in Catecholaminergic Brain Regions: A Marker of Activation following Acute Hypotension and Glucoprivation

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50535 ◽  
Author(s):  
Hanafi A. Damanhuri ◽  
Peter G. R. Burke ◽  
Lin K. Ong ◽  
Larisa Bobrovskaya ◽  
Phillip W. Dickson ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Brain Regions ◽  
Acute Hypotension ◽  
Tyrosine Hydroxylase Phosphorylation
Sign in / Sign up

Export Citation Format

Share Document