scholarly journals The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110

2013 ◽  
Vol 128 (1) ◽  
pp. 196-204 ◽  
Author(s):  
Frances Corrigan ◽  
Emma Thornton ◽  
Laila C. Roisman ◽  
Anna V. Leonard ◽  
Robert Vink ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Binding Site ◽  
Precursor Protein ◽  
Neuroprotective Activity ◽  
Heparin Binding ◽  
Heparin Binding Site

scholarly journals The Adverse Pial Arteriolar and Axonal Consequences of Traumatic Brain Injury Complicated by Hypoxia and Their Therapeutic Modulation with Hypothermia in Rat

2009 ◽  
Vol 30 (3) ◽  
pp. 628-637 ◽  
Author(s):  
Guoyi Gao ◽  
Yasutaka Oda ◽  
Enoch P Wei ◽  
John T Povlishock
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Vascular Reactivity ◽  
Axonal Damage ◽  
Precursor Protein ◽  
Moderate Hypothermia ◽  
Vascular Protection ◽  
Impact Acceleration ◽  
Cerebral Vascular

This study examined the effect of posttraumatic hypoxia on cerebral vascular responsivity and axonal damage, while also exploring hypothermia's potential to attenuate these responses. Rats were subjected to impact acceleration injury (IAI) and equipped with cranial windows to assess vascular reactivity to topical acetylcholine, with postmortem analyses using antibodies to amyloid precursor protein to assess axonal damage. Animals were subjected to hypoxia alone, IAI and hypoxia, IAI and hypoxia before induction of moderate hypothermia (33°C), IAI and hypoxia induced during hypothermic intervention, and IAI and hypoxia initiated after hypothermia. Hypoxia alone had no impact on vascular reactivity or axonal damage. Acceleration injury and posttraumatic hypoxia resulted in dramatic axonal damage and altered vascular reactivity. When IAI and hypoxia were followed by hypothermic intervention, no axonal or vascular protection ensued. However, when IAI was followed by hypoxia induced during hypothermia, axonal and vascular protection followed. When this same hypoxic insult followed the use of hypothermia, no benefit ensued. These studies show that early hypoxia and delayed hypoxia exert damaging axonal and vascular consequences. Although this damage is attenuated by hypothermia, this follows only when hypoxia occurs during hypothermia, with no benefit found if the hypoxic insult proceeds or follows hypothermia.

scholarly journals Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158576 ◽  
Author(s):  
Casandra M. Cartagena ◽  
Andrea Mountney ◽  
Hye Hwang ◽  
Adam Swiercz ◽  
Zoe Rammelkamp ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Penetrating Traumatic Brain Injury

Upregulation of Neuronal Amyloid Precursor Protein (APP) and APP mRNA Following Magnesium Sulphate (MgSO4) Therapy in Traumatic Brain Injury

2000 ◽  
Vol 17 (11) ◽  
pp. 1041-1053 ◽  
Author(s):  
CORINNA VAN DEN HEUVEL ◽  
JOHN W. FINNIE ◽  
PETER C. BLUMBERGS ◽  
JIM MANAVIS ◽  
NIGEL R. JONES ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Magnesium Sulphate ◽  
Precursor Protein

Differential DNA Methylation of the Genes for Amyloid Precursor Protein, Tau, and Neurofilaments in Human Traumatic Brain Injury

2021 ◽  
Author(s):  
Sami Abu Hamdeh ◽  
Diana-Maria Ciuculete ◽  
Daniil Sarkisyan ◽  
Georgy Bakalkin ◽  
Martin Ingelsson ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Dna Methylation ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Protein Tau

An Overview of Inflicted Head Injury in Infants and Young Children, With a Review of β-Amyloid Precursor Protein Immunohistochemistry

2006 ◽  
Vol 130 (5) ◽  
pp. 712-717 ◽  
Author(s):  
David Dolinak ◽  
Ross Reichard
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Young Children ◽  
Amyloid Precursor Protein ◽  
Individual Case ◽  
Precursor Protein ◽  
Inflicted Traumatic Brain Injury ◽  
Β Amyloid ◽  
The Individual ◽  
Infants And Young Children

Abstract Context.—Inflicted traumatic brain injury of infants and young children results in a complex array of autopsy findings. In many cases, immunostains for β-amyloid precursor protein are used to detect axonal injury. Interpretation of the gross, microscopic, and immunostaining results requires the integration of the many facets of the individual case. Objective.—In this article we review the gross and microscopic findings associated with inflicted traumatic brain injury. The application and interpretation of β-amyloid precursor protein immunostains are discussed and photomicrographs are used to illustrate immunostaining patterns. Data Sources.—The pertinent literature is integrated into a review of the subject. Conclusions.—Inflicted traumatic brain injury often results in subdural, subarachnoid, retinal, and optic nerve sheath hemorrhage. These findings must be interpreted within the entire context of the case. β-Amyloid precursor protein immunostains may be helpful in illustrating the traumatic nature of the injuries in some cases.

Upregulation of Amyloid Precursor Protein Messenger RNA in Response to Traumatic Brain Injury: An Ovine Head Impact Model

1999 ◽  
Vol 159 (2) ◽  
pp. 441-450 ◽  
Author(s):  
Corinna Van den Heuvel ◽  
Peter C. Blumbergs ◽  
John W. Finnie ◽  
Jim Manavis ◽  
Nigel R. Jones ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Messenger Rna ◽  
Head Impact ◽  
Precursor Protein ◽  
Impact Model
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