scholarly journals Permissive role of Cdc2 activity induced from astrocytes in neurite outgrowth

2013 ◽  
Vol 125 (2) ◽  
pp. 214-224 ◽  
Author(s):  
In Ae Chang ◽  
Ku-Birm Kwon ◽  
Yang-Chun Park ◽  
Uk Namgung
Keyword(s):  
Neurite Outgrowth ◽  
Cdc2 Activity ◽  
Permissive Role

Permissive role of neutrophils in pathogenesis of indomethacin-induced gastric lesions in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A595-A595
Author(s):  
M TAKEEDA ◽  
Y KOMOIKE ◽  
S KATO ◽  
H MIMAKI ◽  
K TAKEUCHI
Keyword(s):  
Gastric Lesions ◽  
Permissive Role

Role of nitric oxide in the control of renin secretion

1998 ◽  
Vol 275 (6) ◽  
pp. F849-F862 ◽  
Author(s):  
Armin Kurtz ◽  
Charlotte Wagner
Keyword(s):  
Nitric Oxide ◽  
Kinase Activity ◽  
Constitutive Expression ◽  
Juxtaglomerular Apparatus ◽  
Renin Secretion ◽  
Protein Kinase Activity ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Permissive Role

Because of the significant constitutive expression of NO synthases in the juxtaglomerular apparatus, nitric oxide (NO) is considered as a likely modulator of renin secretion. In most instances, NO appears as a tonic enhancer of renin secretion, acting via inhibition of cAMP degradation through the action of cGMP. Depending on as yet unknown factors, the stimulatory effect of NO on renin secretion may also switch to an inhibitory one that is compatible with the inhibition of renin secretion by cGMP-dependent protein kinase activity. Whether NO plays a direct regulatory role or a more permissive role in the control of renin secretion remains to be answered.

Role of PKA in the anti-Thy-1 antibody-induced neurite outgrowth of dorsal root ganglionic neurons

2007 ◽  
Vol 101 (3) ◽  
pp. 566-575 ◽  
Author(s):  
Chien-Hsing Chen ◽  
Yi-Jen Chen ◽  
Chung-Jiuan Jeng ◽  
Shih-Hung Yang ◽  
Po-Yuan Tung ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Dorsal Root

scholarly journals Role of the Rho GTPase-activating protein RICS in neurite outgrowth

2006 ◽  
Vol 11 (6) ◽  
pp. 607-614 ◽  
Author(s):  
Yukiko Nasu-Nishimura ◽  
Tomoatsu Hayashi ◽  
Tomohiro Ohishi ◽  
Toshio Okabe ◽  
Susumu Ohwada ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Rho Gtpase ◽  
Gtpase Activating Protein

Role of synaptotagmin, a Ca2+ and inositol polyphosphate binding protein, in neurotransmitter release and neurite outgrowth

1999 ◽  
Vol 98 (1-2) ◽  
pp. 59-67 ◽  
Author(s):  
Katsuhiko Mikoshiba ◽  
Mitsunori Fukuda ◽  
Keiji Ibata ◽  
Hiroyuki Kabayama ◽  
Akihiro Mizutani
Keyword(s):  
Neurite Outgrowth ◽  
Neurotransmitter Release ◽  
Binding Protein ◽  
Inositol Polyphosphate

Goosecoid suppresses cell growth and enhances neuronal differentiation of PC12 cells

2000 ◽  
Vol 113 (15) ◽  
pp. 2705-2713
Author(s):  
K. Sawada ◽  
Y. Konishi ◽  
M. Tominaga ◽  
Y. Watanabe ◽  
J. Hirano ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Neurite Outgrowth ◽  
Neuronal Differentiation ◽  
Pc12 Cells ◽  
Mammalian Cells ◽  
Homeobox Gene ◽  
S Phase ◽  
Bhlh Transcription Factor ◽  
Spemann Organizer

In all vertebrate species, the homeobox gene goosecoid serves as a marker of the Spemann organizer tissue. One function of the organizer is the induction of neural tissue. To investigate the role of goosecoid in neuronal differentiation of mammalian cells, we have introduced goosecoid into PC12 cells. Expression of goosecoid resulted in reduced cell proliferation and enhanced neurite outgrowth in response to NGF. Expression of goosecoid led to a decrease in the percentage of S-phase cells and to upregulation of the expression of the neuron-specific markers MAP-1b and neurofilament-L. Analysis of goosecoid mutants revealed that these effects were independent of either DNA binding or homodimerization of Goosecoid. Coexpression of the N-terminal portion of the ets transcription factor PU.1, a protein that can bind to Goosecoid, repressed neurite outgrowth and rescued the proliferation of PC12 cultures. In contrast, expression of the bHLH transcription factor HES-1 repressed goosecoid-mediated neurite outgrowth without changing the proportion of S-phase cells. These results suggest that goosecoid is involved in neuronal differentiation in two ways, by slowing the cell cycle and stimulating neurite outgrowth, and that these two events are separately regulated.

Characterization of a PC12 cell sub-clone (PC12-C41) with enhanced neurite outgrowth capacity: implications for a modulatory role of high molecular weight tau in neuritogenesis

1993 ◽  
Vol 106 (2) ◽  
pp. 611-626 ◽  
Author(s):  
K.K. Teng ◽  
I.S. Georgieff ◽  
J.M. Aletta ◽  
J. Nunez ◽  
M.L. Shelanski ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Neurite Outgrowth ◽  
Pc12 Cell ◽  
Cell Types ◽  
Neuronal Morphology ◽  
Cytoskeletal Proteins ◽  
Parental Line ◽  
Pheochromocytoma Cells ◽  
Tau Expression

To address the means by which diversity of neuronal morphology is generated, we have isolated and characterized naturally occurring variants of rat PC12 pheochromocytoma cells that exhibit altered neurite outgrowth properties in response to nerve growth factor (NGF). We describe here a PC12 cell sub-clone, designated PC12-clone 41 (PC12-C41), that displays significant increases in neurite abundance and stability when compared with the parental line. This difference does not appear to be due to an altered sensitivity or responsiveness to NGF or to a more rapid rate of neurite extension. Because of the role of the cytoskeleton in neuritogenesis, we examined a panel of the major cytoskeletal proteins (MAP 1.2/1B, beta-tubulin, chartins, peripherin, and high and low molecular weight (HMW and LMW) taus) whose levels and/or extent of phosphorylation are regulated by NGF in PC12 cultures. Although most cytoskeletal proteins showed little difference between PC12 and PC12-C41 cells (+/- NGF treatment), there was a significant contrast between the two lines with respect to tau expression. In particular, while NGF increases the total specific levels of tau in both cell types to similar extents (by about twofold), the proportion comprising HMW tau is threefold higher in the PC12-C41 clone than in PC12 cells. A comparable difference was observed under substratum conditions that were non-permissive for neurite outgrowth and so this effect was not merely a consequence of the differential neuritogenic capacities of the two lines. The distinction between the expression of HMW and LMW taus in PC12 and PC12-C41 cells (+/- NGF) was also observed at the level of the messages encoding these proteins. Such findings indicate that initiation of neurite outgrowth in PC12 cultures does not require a massive induction of tau expression and raise the possibility that HMW and LMW taus may have differential capacities for modulating neuronal morphology.

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