A Socioecological Predication Model of Posttraumatic Stress Disorder in Low-Income, High-Risk Prenatal Native Hawaiian/Pacific Islander Women

2014 ◽  
Vol 59 (5) ◽  
pp. 494-502 ◽  
Author(s):  
Joan E. Dodgson ◽  
Mary Frances Oneha ◽  
Myunghan Choi
2009 ◽  
Vol 43 (4) ◽  
pp. 635-641 ◽  
Author(s):  
Christopher P Alderman ◽  
Linda C McCarthy ◽  
John T Condon ◽  
Anita C Marwood ◽  
Judith R Fuller

Background: Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder that is common among combat veterans and may lead to very poor sleep and disturbing nightmares. Objective: To examine the safety and effectiveness of topiramate as add-on therapy for the management of combat-related PTSD and to examine the effects of topiramate on sleep and alcohol consumption. Methods: We conducted an 8-week open-label pilot study of topiramate (or male combat veterans (N = 43) with PTSD, with analysis of veterans who completed the protocol. Psychometric, sleep, and alcohol consumption assessments were conducted at baseline and at week 8. Results: Twenty-nine subjects completed the 8-week study. Significant reductions in Clinician Administered PTSD Scale scores were observed at the 8-week endpoint (from 86,3 ± 21.1 to 67.1 ± 25.1; p < 0.01). Decreases were seen in both Stanford Sleepiness Scale scores (from 10.5 ± 0.72 to 9.0 ± 0.58; p = 0.08) and Mississippi PTSD scores (from 120.4 ± 6.5 to 111.5 ± 20.9; p = 0.08), but the extent of the changes did not attain statistical significance for either scale. There was a significant reduction in the proportion of patients with nightmares (from 100% to 62%; p < 0.001) and patients who experienced anxiety that interfered with falling asleep (from 90% to 62%; p < 0.05). The proportion of patients with high-risk drinking patterns also decreased (from 31% to 14%). Two serious adverse events were reported during the study: an increase in tow back pain and an episode of acute confusion. Conclusions: When used in addition to other empiric therapy, topiramate may be effective at reducing general symptoms of combat-related PTSD and reducing high-risk alcohol intake and nightmares. Further randomized controlled trials of topiramate for the treatment of combat-related PTSD are warranted.


1999 ◽  
Vol 12 (1) ◽  
pp. 59-72 ◽  
Author(s):  
Martie P. Thompson ◽  
Nadine J. Kaslow ◽  
J. B. Kingree ◽  
Robin Puett ◽  
Nancy J. Thompson ◽  
...  

2008 ◽  
Vol 21 (2) ◽  
pp. 218-222 ◽  
Author(s):  
Regina G. Davis ◽  
Kerry J. Ressler ◽  
Ann C. Schwartz ◽  
Kisha James Stephens ◽  
Rebekah G. Bradley

2006 ◽  
Vol 163 (5) ◽  
pp. 881-884 ◽  
Author(s):  
Megan V. Smith ◽  
Karalee Poschman ◽  
Mary A. Cavaleri ◽  
Heather B. Howell ◽  
Kimberly A. Yonkers

2008 ◽  
Vol 18 (5) ◽  
pp. 497-507 ◽  
Author(s):  
Janice L. Krupnick ◽  
Bonnie L. Green ◽  
Patricia Stockton ◽  
Jeanne Miranda ◽  
Elizabeth Krause ◽  
...  

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