Reference value of hematologic, urologic, and organ weights of 2‐ to 4‐year‐old long‐tailed macaques ( Macaca fascicularis fascicularis ) in the context of toxicological studies

2021 ◽  
Author(s):  
Jinhyung Rho ◽  
Ju‐Yeon Lee ◽  
Mi‐Jin Yang
Keyword(s):  
Macaca Fascicularis ◽  
Reference Value ◽  
Organ Weights ◽  
Toxicological Studies

A note on statistical analysis of organ weights in non-clinical toxicological studies

2009 ◽  
Vol 240 (1) ◽  
pp. 117-122 ◽  
Author(s):  
Martin J. Wolfsegger ◽  
Thomas Jaki ◽  
Barbara Dietrich ◽  
Jackie A. Kunzler ◽  
Kerry Barker
Keyword(s):  
Statistical Analysis ◽  
Organ Weights ◽  
Toxicological Studies

Author response for "Quantitative assessment of amygdala in macaca fascicularis monkeys"

2020 ◽  
Author(s):  
José‐Carlos Delgado‐González ◽  
Carlos‐de‐la Rosa Prieto ◽  
Nuria Vallejo‐Calcerrada ◽  
Diana‐Lucía Tarruela‐Hernández ◽  
Sandra Cebada‐Sánchez ◽  
...  
Keyword(s):  
Quantitative Assessment ◽  
Macaca Fascicularis ◽  
Author Response

Reduction of spermatogonia and testosterone in rat testes flown on space lab-3

1986 ◽  
Vol 44 ◽  
pp. 248-249
Author(s):  
Delbert E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
T. Fast ◽  
J. Stevenson ◽  
...  
Keyword(s):  
Social Interaction ◽  
Social Status ◽  
Population Size ◽  
Physiological Response ◽  
Social Rank ◽  
Reproductive Function ◽  
Testicular Development ◽  
Organ Weights ◽  
Reproductive Maturation ◽  
Metabolic Activities

Space Lab 3 (SL-3) was flown on Shuttle Challenger providing an opportunity to measure the effect of spaceflight on rat testes. Cannon developed the idea that organisms react to unfavorable conditions with highly integrated metabolic activities. Selye summarized the manifestations of physiological response to nonspecific stress and he pointed out that atrophy of the gonads always occurred. Many papers have been published showing the effects of social interaction, crowding, peck order and confinement. Flickinger showed delayed testicular development in subordinate roosters influenced by group numbers, social rank and social status. Christian reported increasing population size in mice resulted in adrenal hypertrophy, inhibition of reproductive maturation and loss of reproductive function in adults. Sex organ weights also declined. Two male dogs were flown on Cosmos 110 for 22 days. Fedorova reported an increase of 30 to 70% atypical spermatozoa consisting of tail curling and/or the absence of a tail.

Ultrastructure of the lesion induced by toxin T-514 isolated from K. humboldtiana in the alveolar region of the lung

1992 ◽  
Vol 50 (1) ◽  
pp. 640-641
Author(s):  
Julio Sepúlveda-Saavedra ◽  
Beatriz González-Corona ◽  
Víctor A. Tamez Rodríguez ◽  
Ma. Victoria Bermúdez de Rocha ◽  
Alfredo Piñeyro López
Keyword(s):  
Electron Microscope ◽  
Guinea Pig ◽  
Macaca Fascicularis ◽  
Osmium Tetroxide ◽  
Lead Citrate ◽  
Severe Damage ◽  
Thin Sections ◽  
Alveolar Region ◽  
Histopathological Findings

It has been shown in previous studies that the toxin T-514 isolated from K. humboldtiana induces severe damage to the lung in treated rodents. Histopathological findings include edema, and alveolar hemorrage. However, the ultraestructure of the lesion has not been investigated. In this study we used two species of rodents: Hamster and guinea pig, and a primate: Macaca fascicularis. Animals received different single dosis of the toxin via intraperitoneal. Control animals received only the vehicle (propylen glycol). Inmediately after spontaneous death, lung samples were fixed in Karnovsky-Ito fixative, post fixed in osmium tetroxide and embedded in epon. Thin sections were prepared with an Ultratome V LKB, stained with uranly acetate and lead citrate, and studied in an electron microscope Zeiss-EM109.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Toxicological studies on the Eugenia dysenterica DC and Caryocar brasiliense Cambess leaves in rats

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
F Elias ◽  
T Zils ◽  
FGL Aguiar ◽  
ELE Barros ◽  
ME Molica ◽  
...  
Keyword(s):  
Toxicological Studies ◽  
Caryocar Brasiliense ◽  
Eugenia Dysenterica ◽  
Caryocar Brasiliense Cambess

Analysis of stably expressed genes with low-dose etoposide for toxicological studies in osteosarcoma

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
JMP Ferreira de Oliveira ◽  
L Almeida ◽  
F Pimentel ◽  
EJJ Van Zoelen ◽  
C Santos
Keyword(s):  
Low Dose ◽  
Toxicological Studies
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