Effects of transdermal mirtazapine on hyporexic rhesus and cynomolgus macaques ( Macaca mulatta and Macaca fascicularis )

2021 ◽  
Vol 50 (2) ◽  
pp. 128-133
Author(s):  
Kriscelle A. Mendoza ◽  
Diane E. Stockinger ◽  
Mira J. Cukrov ◽  
Jeffrey A. Roberts ◽  
Granger G.C. Hwa
2020 ◽  
Author(s):  
Justyna Marchewka ◽  
Kamil Mrożek ◽  
Bartosz Leszczyński ◽  
Andrzej Wróbel ◽  
Henryk Głąb

Author(s):  
Alexandra N Witt ◽  
Rachel D Green ◽  
Andrew N Winterborn

Animal models are at the forefront of biomedical research for studies of viral transmission, vaccines, and pathogenesis, yetthe need for an ideal large animal model for COVID-19 remains. We used a meta-analysis to evaluate published data relevantto this need. Our literature survey contained 22 studies with data relevant to the incidence of common COVID-19 symptomsin rhesus macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis), African green monkeys (Chlorocebusaethiops), and ferrets (Mustela putorius furo). Rhesus macaques had leukocytosis on Day 1 after inoculation and pneumonia on Days 7 and 14 after inoculation, in frequencies that were similar enough to humans to reject the null hypothesis of a Fisher exact test. However, the differences in overall presentation of disease were too different from that of humans to successfully identify any of these 4 species as an ideal large animal of COVID-19. The greatest limitation to the current study is a lack of standardization in experimentation and reporting. To expand our understanding of the pathology of COVID-19 and evaluate vaccine immunogenicity, we must extend the unprecedented collaboration that has arisen in the study of COVID-19 to include standardization of animal-based research in an effort to find the optimal animal model.


Animals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 60
Author(s):  
Brooke Catherine Aldrich ◽  
David Neale

In this article, we attempt to characterize the widespread trade in pet macaques in Vietnam. Data on confiscations as well as surrenders, releases, and individuals housed at rescue centers across Vietnam for 2015–2019 were opportunistically recorded. Data comparisons between Education for Nature Vietnam and three government-run wildlife rescue centers show that at least 1254 cases of macaque keeping occurred during the study period, including a minimum of 32 Assamese macaques (Macaca assamensis), 158 long-tailed macaques (Macaca fascicularis), 291 Northern pig-tailed macaques (Macaca leonina), 65 rhesus macaques (Macaca mulatta), and 110 stump-tailed macaques (Macaca arctoides). A minimum of 423 individuals were confiscated, and at least 490 individual macaques were released. Three semi-structured interviews were conducted with two key Animals Asia (a non-governmental organization) colleagues and their insights are presented. Although we recognize that the data included are limited and can serve only as a baseline for the scale of the macaque pet trade in Vietnam, we believe that they support our concern that the problem is significant and must be addressed. We stress the need for organizations and authorities to work together to better understand the issue. The keeping of macaques as pets is the cause of serious welfare and conservation issues in Vietnam.


2001 ◽  
Vol 35 (4) ◽  
pp. 315-320 ◽  
Author(s):  
S. E. Wolfensohn ◽  
R. Gopal

In 1992 an annual Simian herpes B virus (BV) screening programme for an experimental group of macaque monkeys ( Macaca mulatta and Macaca fascicularis) was initiated with the aim of establishing a specific pathogen free (SPF) colony. In June 1999 one animal was found to be unexpectedly BV positive (non-negative). The investigation of this result highlights some of the issues and difficulties that may be encountered in such a programme.


PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12880 ◽  
Author(s):  
Aysegul Nalca ◽  
Virginia A. Livingston ◽  
Nicole L. Garza ◽  
Elizabeth E. Zumbrun ◽  
Ondraya M. Frick ◽  
...  

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