Micro-CT versus synchrotron radiation phase contrast imaging of human cochlea

2016 ◽  
Vol 265 (3) ◽  
pp. 349-357 ◽  
Author(s):  
M. ELFARNAWANY ◽  
S. RIYAHI ALAM ◽  
S.A. ROHANI ◽  
N. ZHU ◽  
S.K. AGRAWAL ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Phase Contrast ◽  
Phase Contrast Imaging ◽  
Micro Ct ◽  
Contrast Imaging ◽  
Human Cochlea ◽  
Radiation Phase

scholarly journals Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hao Li ◽  
Luke Helpard ◽  
Jonas Ekeroot ◽  
Seyed Alireza Rohani ◽  
Ning Zhu ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Phase Contrast ◽  
Spiral Ganglion ◽  
Three Dimensional ◽  
Nerve Fibers ◽  
Frequency Function ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
Human Cochlea ◽  
Radiation Phase

AbstractThe human cochlea transforms sound waves into electrical signals in the acoustic nerve fibers with high acuity. This transformation occurs via vibrating anisotropic membranes (basilar and tectorial membranes) and frequency-specific hair cell receptors. Frequency-positions can be mapped within the cochlea to create a tonotopic chart which fits an almost-exponential function with lowest frequencies positioned apically and highest frequencies positioned at the cochlear base (Bekesy 1960, Greenwood 1961). To date, models of frequency positions have been based on a two-dimensional analysis with inaccurate representations of the cochlear hook region. In the present study, the first three-dimensional frequency analysis of the cochlea using dendritic mapping to obtain accurate tonotopic maps of the human basilar membrane/organ of Corti and the spiral ganglion was performed. A novel imaging technique, synchrotron radiation phase-contrast imaging, was used and a spiral ganglion frequency function was estimated by nonlinear least squares fitting a Greenwood-like function (F = A (10ax − K)) to the data. The three-dimensional tonotopic data presented herein has large implications for validating electrode position and creating customized frequency maps for cochlear implant recipients.

scholarly journals Visualizing the 3D cytoarchitecture of the human cochlea in an intact temporal bone using synchrotron radiation phase contrast imaging

2018 ◽  
Vol 9 (8) ◽  
pp. 3757 ◽  
Author(s):  
Janani S. Iyer ◽  
Ning Zhu ◽  
Sergei Gasilov ◽  
Hanif M. Ladak ◽  
Sumit K. Agrawal ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Temporal Bone ◽  
Phase Contrast ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
Human Cochlea ◽  
Radiation Phase

Improved middle-ear soft-tissue visualization using synchrotron radiation phase-contrast imaging

2017 ◽  
Vol 354 ◽  
pp. 1-8 ◽  
Author(s):  
Mai Elfarnawany ◽  
Seyed Alireza Rohani ◽  
Soroush Ghomashchi ◽  
Daniel G. Allen ◽  
Ning Zhu ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Soft Tissue ◽  
Middle Ear ◽  
Phase Contrast ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
Radiation Phase

Microvoids in Solids: Synchrotron Radiation Phase Contrast Imaging and Simulations

2018 ◽  
Vol 255 (9) ◽  
pp. 1800209 ◽  
Author(s):  
Victor G. Kohn ◽  
Tatiana S. Argunova ◽  
Jung Ho Je
Keyword(s):  
Synchrotron Radiation ◽  
Phase Contrast ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
Radiation Phase

Microbubble-based synchrotron radiation phase contrast imaging: basic study and angiography applications

2011 ◽  
Vol 56 (12) ◽  
pp. 3503-3512 ◽  
Author(s):  
Rongbiao Tang ◽  
Yan Xi ◽  
Wei-Min Chai ◽  
Yongting Wang ◽  
Yongjing Guan ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Phase Contrast ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
Basic Study ◽  
Radiation Phase

scholarly journals Characterization of the human helicotrema: implications for cochlear duct length and frequency mapping

2020 ◽  
Vol 49 (1) ◽  
Author(s):  
Luke Helpard ◽  
Hao Li ◽  
Helge Rask-Andersen ◽  
Hanif M. Ladak ◽  
Sumit K. Agrawal
Keyword(s):  
Regression Analysis ◽  
Synchrotron Radiation ◽  
Phase Contrast ◽  
Anatomical Variation ◽  
Phase Contrast Imaging ◽  
Patient Specific ◽  
Contrast Imaging ◽  
Cochlear Duct ◽  
Cochlear Duct Length ◽  
Radiation Phase

Abstract Background Despite significant anatomical variation amongst patients, cochlear implant frequency-mapping has traditionally followed a patient-independent approach. Basilar membrane (BM) length is required for patient-specific frequency-mapping, however cochlear duct length (CDL) measurements generally extend to the apical tip of the entire cochlea or have no clearly defined end-point. By characterizing the length between the end of the BM and the apical tip of the entire cochlea (helicotrema length), current CDL models can be corrected to obtain the appropriate BM length. Synchrotron radiation phase-contrast imaging has made this analysis possible due to the soft-tissue contrast through the entire cochlear apex. Methods Helicotrema linear length and helicotrema angular length measurements were performed on synchrotron radiation phase-contrast imaging data of 14 cadaveric human cochleae. On a sub-set of six samples, the CDL to the apical tip of the entire cochlea (CDLTIP) and the BM length (CDLBM) were determined. Regression analysis was performed to assess the relationship between CDLTIP and CDLBM. Results The mean helicotrema linear length and helicotrema angular length values were 1.6 ± 0.9 mm and 67.8 ± 37.9 degrees, respectively. Regression analysis revealed the following relationship between CDLTIP and CDLBM: CDLBM = 0.88(CDLTIP) + 3.71 (R2 = 0.995). Conclusion This is the first known study to characterize the length of the helicotrema in the context of CDL measurements. It was determined that the distance between the end of the BM and the tip of the entire cochlea is clinically consequential. A relationship was determined that can predict the BM length of an individual patient based on their respective CDL measured to the apical tip of the cochlea.

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