Social cognition dysfunction in adolescents with 22q11.2 deletion syndrome (velo-cardio-facial syndrome): relationship with executive functioning and social competence/functioning

2015 ◽  
Vol 59 (9) ◽  
pp. 845-859 ◽  
Author(s):  
L. E. Campbell ◽  
K. L. McCabe ◽  
J. L. Melville ◽  
P. A. Strutt ◽  
U. Schall
Keyword(s):  
Social Cognition ◽  
Social Competence ◽  
Executive Functioning ◽  
22Q11.2 Deletion Syndrome ◽  
Deletion Syndrome ◽  
22Q11.2 Deletion ◽  
Cognition Dysfunction ◽  
Velo Cardio Facial Syndrome

Genetic and clinical features of social cognition in 22q11.2 deletion syndrome

2018 ◽  
Vol 96 (10) ◽  
pp. 1631-1640 ◽  
Author(s):  
Guido Maria Lattanzi ◽  
Antonino Buzzanca ◽  
Marianna Frascarelli ◽  
Fabio Di Fabio
Keyword(s):  
Social Cognition ◽  
Clinical Features ◽  
22Q11.2 Deletion Syndrome ◽  
Deletion Syndrome ◽  
22Q11.2 Deletion

scholarly journals Executive functioning and its relation to ASD and ADHD symptomatology in 22q11.2 deletion syndrome*

2016 ◽  
Vol 24 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Leo M. J. de Sonneville ◽  
Elske Hidding ◽  
Herman van Engeland ◽  
Jacob A. S. Vorstman ◽  
Monique E. J. Sijmens-Morcus ◽  
...  
Keyword(s):  
Executive Functioning ◽  
22Q11.2 Deletion Syndrome ◽  
Deletion Syndrome ◽  
22Q11.2 Deletion ◽  
Adhd Symptomatology

scholarly journals Cingulate gyral reductions are related to low executive functioning and psychotic symptoms in 22q11.2 deletion syndrome

2008 ◽  
Vol 46 (12) ◽  
pp. 2986-2992 ◽  
Author(s):  
Federico Dufour ◽  
Marie Schaer ◽  
Martin Debbané ◽  
Riaz Farhoumand ◽  
Bronwyn Glaser ◽  
...  
Keyword(s):  
Executive Functioning ◽  
22Q11.2 Deletion Syndrome ◽  
Deletion Syndrome ◽  
Psychotic Symptoms ◽  
22Q11.2 Deletion

scholarly journals Cognitive development in children with 22q11.2 deletion syndrome

2012 ◽  
Vol 200 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Sasja N. Duijff ◽  
Petra W. J. Klaassen ◽  
Henriette F. N. Swanenburg de Veye ◽  
Frits A. Beemer ◽  
Gerben Sinnema ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Cognitive Abilities ◽  
22Q11.2 Deletion Syndrome ◽  
Deletion Syndrome ◽  
First Episode ◽  
22Q11.2 Deletion ◽  
Cross Sectional ◽  
Cognitive Faculties ◽  
Relative Decline ◽  
Velo Cardio Facial Syndrome

BackgroundPeople with 22q11.2 deletion syndrome (velo-cardio-facial syndrome) have a 30-fold risk of developing schizophrenia. In the general population the schizophrenia phenotype includes a cognitive deficit and a decline in academic performance preceding the first episode of psychosis in a subgroup of patients. Findings of cross-sectional studies suggest that cognitive abilities may decline over time in some children with 22q11.2 deletion syndrome. If confirmed longitudinally, this could indicate that one or more genes within 22q11.2 are involved in cognitive decline.AimsTo assess longitudinally the change in IQ scores in children with 22q11.2 deletion syndrome.MethodSixty-nine children with the syndrome were cognitively assessed two or three times at set ages 5.5 years, 7.5 years and 9.5 years.ResultsA mean significant decline of 9.7 Full Scale IQ points was found between ages 5.5 years and 9.5 years. In addition to the overall relative decline that occurred when results were scored according to age-specific IQ norms, in 10 out of a group of 29 children an absolute decrease in cognitive raw scores was found between ages 7.5 years and 9.5 years. The decline was not associated with a change in behavioural measures.ConclusionsThe finding of cognitive decline can be only partly explained as the result of ‘growing into deficit’; about a third of 29 children showed an absolute loss of cognitive faculties. The results underline the importance of early psychiatric screening in this population and indicate that further study of the genes at the 22q11.2 locus may be relevant to understanding the genetic basis of early cognitive deterioration.

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