scholarly journals The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice

2017 ◽  
Vol 59 (9) ◽  
pp. 612-628 ◽  
Author(s):  
Xiaolei Zhu ◽  
Jing Yu ◽  
Jianxin Shi ◽  
Takayuki Tohge ◽  
Alisdair R. Fernie ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Pollen Exine ◽  
Ubisch Body ◽  
Body Patterning

The Structure and Rearrangements of a Complete Polyketide Synthase Module During its Catalytic Cycle

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
DH Sherman ◽  
G Skiniotis ◽  
JL Smith ◽  
K Håkansson ◽  
S Dutta ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Catalytic Cycle

scholarly journals Tetrodotoxins (TTXs) and Vibrio alginolyticus in Mussels from Central Adriatic Sea (Italy): Are They Closely Related?

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 304
Author(s):  
Simone Bacchiocchi ◽  
Debora Campacci ◽  
Melania Siracusa ◽  
Alessandra Dubbini ◽  
Francesca Leoni ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mytilus Galloprovincialis ◽  
Polyketide Synthase ◽  
Adriatic Sea ◽  
Tandem Mass ◽  
Hydrophilic Interaction ◽  
Marche Region ◽  
Peptide Synthetase ◽  
Scientific Opinion ◽  
Vibrio Spp

Tetrodotoxins (TTXs), potent neurotoxins, have become an increasing concern in Europe in recent decades, especially because of their presence in mollusks. The European Food Safety Authority published a Scientific Opinion setting a recommended threshold for TTX in mollusks of 44 µg equivalent kg−1 and calling all member states to contribute to an effort to gather data in order to produce a more exhaustive risk assessment. The objective of this work was to assess TTX levels in wild and farmed mussels (Mytilus galloprovincialis) harvested in 2018–2019 along the coastal area of the Marche region in the Central Adriatic Sea (Italy). The presence of Vibrio spp. carrying the non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) genes, which are suspected to be involved in TTX biosynthesis, was also investigated. Out of 158 mussel samples analyzed by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry (HILIC-MS/MS), 11 (7%) contained the toxins at detectable levels (8–26 µg kg−1) and 3 (2%) contained levels above the EFSA safety threshold (61–76 µg kg−1). Contaminated mussels were all harvested from natural beds in spring or summer. Of the 2019 samples, 70% of them contained V. alginolyticus strains with the NRPS and/or PKS genes. None of the strains containing NRPS and/or PKS genes showed detectable levels of TTXs. TTXs in mussels are not yet a threat in the Marche region nor in Europe, but further investigations are surely needed.

scholarly journals Polyketide Double Bond Biosynthesis. Mechanistic Analysis of the Dehydratase-Containing Module 2 of the Picromycin/Methymycin Polyketide Synthase

2005 ◽  
Vol 127 (49) ◽  
pp. 17393-17404 ◽  
Author(s):  
Jiaquan Wu ◽  
Toby J. Zaleski ◽  
Chiara Valenzano ◽  
Chaitan Khosla ◽  
David E. Cane
Keyword(s):  
Double Bond ◽  
Polyketide Synthase ◽  
Mechanistic Analysis
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