scholarly journals Meta-analysis and candidate gene mining of low-phosphorus tolerance in maize

2014 ◽  
Vol 56 (3) ◽  
pp. 262-270 ◽  
Author(s):  
Hongwei Zhang ◽  
Mohammed Shalim Uddin ◽  
Cheng Zou ◽  
Chuanxiao Xie ◽  
Yunbi Xu ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Meta Analysis ◽  
Gene Mining ◽  
Low Phosphorus ◽  
Low Phosphorus Tolerance

scholarly journals Meta-analysis of soybean amino acid QTLs and candidate gene mining

2018 ◽  
Vol 17 (5) ◽  
pp. 1074-1084 ◽  
Author(s):  
Qian-chun GONG ◽  
Hong-xiao YU ◽  
Xin-rui MAO ◽  
Hui-dong QI ◽  
Yan SHI ◽  
...  
Keyword(s):  
Amino Acid ◽  
Candidate Gene ◽  
Meta Analysis ◽  
Gene Mining

Meta-analysis and overview analysis of quantitative trait locis associated with fatty acid content in soybean for candidate gene mining

2018 ◽  
Vol 137 (2) ◽  
pp. 181-193 ◽  
Author(s):  
Hongtao Qin ◽  
Zhangxiong Liu ◽  
Yuyang Wang ◽  
Mingyue Xu ◽  
Xinrui Mao ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Candidate Gene ◽  
Quantitative Trait ◽  
Acid Content ◽  
Meta Analysis ◽  
Fatty Acid Content ◽  
Gene Mining ◽  
Overview Analysis

scholarly journals Triterpenoid Saponin Biosynthetic Pathway Profiling and Candidate Gene Mining of the Ilex asprella Root Using RNA-Seq

2014 ◽  
Vol 15 (4) ◽  
pp. 5970-5987 ◽  
Author(s):  
Xiasheng Zheng ◽  
Hui Xu ◽  
Xinye Ma ◽  
Ruoting Zhan ◽  
Weiwen Chen
Keyword(s):  
Candidate Gene ◽  
Biosynthetic Pathway ◽  
Triterpenoid Saponin ◽  
Rna Seq ◽  
Gene Mining

Candidate gene studies of fibromyalgia: a systematic review and meta-analysis

2010 ◽  
Vol 32 (2) ◽  
pp. 417-426 ◽  
Author(s):  
Young Ho Lee ◽  
Sung Jae Choi ◽  
Jong Dae Ji ◽  
Gwan Gyu Song
Keyword(s):  
Systematic Review ◽  
Candidate Gene ◽  
Meta Analysis ◽  
Candidate Gene Studies

scholarly journals Candidate gene studies in gallbladder cancer: A systematic review and meta-analysis

2011 ◽  
Vol 728 (1-2) ◽  
pp. 67-79 ◽  
Author(s):  
Kshitij Srivastava ◽  
Anvesha Srivastava ◽  
Kiran Lata Sharma ◽  
Balraj Mittal
Keyword(s):  
Systematic Review ◽  
Candidate Gene ◽  
Gallbladder Cancer ◽  
Meta Analysis ◽  
Candidate Gene Studies

Abstract P002: Evidence For Smoking Dependent Genetic Effects on C-reactive Protein Levels in a Multi-ethnic Cohort Setting: The Care Consortium.

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Jaclyn Ellis ◽  
Jeremy Walston ◽  
Josee Dupuis ◽  
Emma Larkin ◽  
Maja Barbalic ◽  
...  
Keyword(s):  
African Americans ◽  
Candidate Gene ◽  
Meta Analysis ◽  
Cardiovascular Health Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
European Americans ◽  
Heart Study ◽  
Study Results ◽  
Never Smokers

INTRODUCTION: C-reactive protein (CRP) is a heritable biomarker of systemic inflammation and a predictor of cardiovascular disease (CVD). Cigarette smoking is a major risk factor in the development of CVD and has been shown to affect circulating levels of CRP. Therefore, we sought to determine how this important environmental exposure may influence genetic associations with CRP in a multi-ethnic setting. METHODS: Using the ITMAT Broad-CARe (IBC) SNP array, a custom 50,000 SNP gene-centric array having dense coverage of over 2,000 candidate genes for CVD pathways, we performed a meta-analysis of up to 26,065 participants of European descent and 7,584 participants of African descent for association with log-CRP level within smoking status stratum. The 2 smoking strata were: never smokers and ever smokers (comprising of current and former smokers). We conducted IBC-wide association scans for CRP within cohort-, race- and smoking-stratum and meta-analyzed by race. Samples were from the Candidate gene Association Resource (CARe) cohorts (Atherosclerosis Risk in Communities Study, Framingham Heart Study, Cardiovascular Health Study, Cleveland Family Study , Coronary Artery Risk Development in Young Adults Study, Jackson Heart Study, and Multi-Ethnic Study of Atherosclerosis Study). Results were considered to be panel wide statistically significant if p<2.2×10−6. RESULTS: The overall sample size for ever smokers (never smokers) was 11,698 (10,344) in European Americans and 3,448 (4,330) in African Americans. The per-allele beta coefficients for genes previously established to be associated with CRP and present on the IBC chip ( CRP, APOE, GCKR, IL6R, LEPR, HNF1A, NLRP3 ) were very similar in magnitude between smoking strata in European Americans. However, in the African Americans, the estimated per-allele CRP and IL6R betas were 2-times larger for the ever smokers as compared to the never smokers. In the European American analysis, one gene not previously reported for association with CRP reached IBC-wide significance for a CRP-lowering effect in the never smokers ( GSTT1 , p=4.8E-07 for SNP rs405597 ), but not in the ever smokers (p=0.078). CONCLUSION: This large scale candidate gene based meta-analysis identified one novel locus for CRP ( GSTT1 ) associated with serum CRP levels in those reporting having never regularly smoked. Polymorphisms in GSTT1 , which plays a role in detoxification, have previously been reported to interact with smoking for other phenotypes including birth weight and colorectal cancer. We also observed evidence that smoking modifies the effects for previously established loci CRP and IL6R in African Americans. These results may identify important context genetic specific effects that influence chronic inflammation.

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