scholarly journals Role of the rs10401670 variant in the resistin gene on the metabolic response after weight loss secondary to a high‐fat hypocaloric diet with a Mediterranean pattern

2021 ◽  
Author(s):  
Daniel Luis ◽  
Rocío Aller ◽  
Olatz Izaola ◽  
David Primo
Keyword(s):  
Weight Loss ◽  
Metabolic Response ◽  
Hypocaloric Diet ◽  
High Fat

scholarly journals The role of extended antral resection on weight loss and metabolic response after sleeve gastrectomy: A retrospective cohort study

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Adem Yuksel ◽  
Murat Coskun ◽  
Kerem Karaman
Keyword(s):  
Weight Loss ◽  
Cohort Study ◽  
Sleeve Gastrectomy ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Metabolic Response ◽  
Clinical Results ◽  
First Year ◽  
Antral Resection

Objective: The impact of extended antral resection (AR) after laparoscopic sleeve gastrectomy (LSG) on clinical results is still not clearly elucidated with conflicting results. Our study aimed to determine whether AR is superior to antral preservation (AP) regarding clinical results. Methods: Patients were divided into two groups according to the distance of gastric division as AR group (2cm from pylorus) and AP group (6cm from pylorus). Postoperative excess weight loss percentile (%EWL) and total body weight loss percentiles (%TBWL) at the end of first, 6th and 12 months were compared. Secondly, metabolic parameters and complications were compared. Results: The first 68 patients underwent AP, and the following 43 patients underwent AR. Although statistically not significant, AR achieve more %EWL and %TBWL at the end of the first year, (P>0.05). On the other hand, metabolic parameters were similar at the end of the first year, (P>0.05). Resolution of comorbidities were statistically not different, (P>0.05). Staple line leak occurred in two patients of the AR group (4.7%) and two patients of the AP group (2.9%), (P>0.05). Conclusion: Both AR and AP seem to be equally effective in resolution of metabolic response. Although statistically not significant- AR provided more %EWL and %TBWL at the end of 12 months. doi: https://doi.org/10.12669/pjms.36.6.2321 How to cite this:Yuksel A, Coskun M, Karaman K. The role of extended antral resection on weight loss and metabolic response after sleeve gastrectomy: A retrospective cohort study. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2321 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The rs9939609 Gene Variant in FTO Modified the Metabolic Response of Weight Loss After a 3-Month Intervention With a Hypocaloric Diet

2013 ◽  
Vol 61 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Rocío Aller ◽  
Rosa Conde ◽  
Olatz Izaola ◽  
Manuel Gonzalez Sagrado ◽  
...  
Keyword(s):  
Weight Loss ◽  
Metabolic Response ◽  
Hypocaloric Diet ◽  
Gene Variant

scholarly journals Serum Lipid and Adiponectin Improvements after a Mediterranean Dietary Pattern in Non-G-Allele Carriers of the Variant rs3774261

2020 ◽  
Vol 13 (6) ◽  
pp. 164-171
Author(s):  
Daniel A. de Luis ◽  
David Primo ◽  
Olatz Izaola ◽  
Emilia Gómez ◽  
Rosario Bachiller
Keyword(s):  
Weight Loss ◽  
Dietary Pattern ◽  
Serum Lipid ◽  
Dietary Intervention ◽  
Metabolic Response ◽  
Serum Levels ◽  
Hypocaloric Diet ◽  
Genotype Distribution ◽  
Model Assessment ◽  
Mediterranean Dietary Pattern

<b><i>Background:</i></b> The role of adiponectin (<i>ADIPOQ</i>) polymorphisms in weight loss and serum lipid changes following different dietary interventions remain unclear. The Mediterranean dietary pattern has been associated with improved cardiovascular risk factors in different studies. <b><i>Objective:</i></b> Our aim was to analyze the effects of a hypocaloric diet with a Mediterranean dietary pattern on the metabolic response and adiposity parameters, taking into account the 712 G/A rs3774261 polymorphisms in <i>ADIPOQ</i>. <b><i>Design:</i></b> A population of 135 obese patients was enrolled. Anthropometric and serum parameters (lipid profile, insulin, homeostasis model assessment for insulin resistance [HOMA-IR], glucose, C-reactive protein [CRP], adiponectin, resistin, and leptin levels) were measured before and after the dietary intervention (12 weeks). All of the patients were genotyped for the rs3774261 polymorphism. <b><i>Results:</i></b> The genotype distribution of this population was 36 patients with AA (26.7%), 68 patients with AG (50.4%), and 31 patients with GG (22.9%). After the dietary intervention and in both genotypes, BMI, weight, fat mass, systolic blood pressure, waist circumference, glucose, insulin, HOMA-IR, and leptin levels all decreased. After the dietary intervention with secondary weight loss and in non-G-allele carriers (AA vs. AG+GG), total cholesterol (Δ = –15.7 ± 3.9 vs. –4.9 ± 2.9 mg/dL; <i>p</i> = 0.02), LDL cholesterol (Δ = –15.3 ± 3.8 vs. –1.7 ± 1.9 mg/dL; <i>p</i> = 0.01), triglyceride levels (Δ = –23.4 ± 5.6 vs. 2.3 ± 2.3 mg/dL; <i>p</i> = 0.01), and CRP (Δ = –1.1 ± 0.1 vs. –0.4 ± 0.2 mg/dL; <i>p</i> = 0.01) decreased. Adiponectin levels (Δ = 7.2 ± 2.1 vs. –0.4 ± 0.3 ng/dL; <i>p</i> = 0.02) increased. Notably, G-allele carriers did not show this improvement. <b><i>Conclusion:</i></b> Non-G-allele carriers of the <i>ADIPOQ</i> variant (rs3774261) showed significant improvement in serum levels of adiponectin, lipid profiles, and CRP in response to a hypocaloric diet with a Mediterranean dietary pattern.

Impact of 2 Different Hypocaloric Diets on Serum Omentin Levels in Obese Subjects

2018 ◽  
Vol 73 (2) ◽  
pp. 138-144 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
Olatz Izaola ◽  
David Primo ◽  
Rocío Aller
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Post Treatment ◽  
Hypocaloric Diet ◽  
Type I ◽  
Statistical Association ◽  
High Fat ◽  
Low Fat ◽  
Low Fat Diet ◽  
Obese Subjects

Background and Aims: Omentin-1 might play a role in insulin resistance and obesity. This study is aimed at evaluating the influence of weight loss treatment on omentin-1 concentrations and other parameters after 2 different hypocaloric diets in obese subjects. Methods: A total of 239 obese subjects were randomly allocated during 12 weeks (Diet I – high-fat diet vs. Diet II – low fat diet), and their anthropometric and biochemical status were evaluated. Results: After dietary intervention, BMI, weight, fat mass, waist circumference, systolic blood, triglycerides, LDL cholesterol, insulin levels and homeostasis model assessment for insulin resistance decreased in a statistical manner from their base values. After consuming diet II (low fat diet), the omentin-1 levels increased in males (20 ± 14 ng/mL) and females (35 ± 19 ng/mL). No changes were observed in omentin-1 levels after consuming hypocaloric diet type I (high fat). The multiple regression analyses after weight loss with diet I adjusted by age and sex showed a statistical association between BMI kg/m2 (Beta –0.33: 95% CI –4.58 to –0.11) and post-treatment omentin-1 levels. The analysis after weight loss with diet II showed a statistical association with BMI kg/m2 (Beta –0.31: 95% CI –3.93 to –0.08) and insulin UI/L (Beta –0.25: 95% CI –4.63 to –0.05) with post-treatment omentin-1 levels. Conclusions: Our design showed a significant increase in serum omentin-1 levels after weight loss secondary to a low fat hypocaloric diet, in contrast to no changes following consuming a high fat hypocaloric diet.

Role of the variant in adiponectin gene rs266729 on weight loss and cardiovascular risk factors after a hypocaloric diet with the Mediterranean pattern

Nutrition ◽  
2019 ◽  
Vol 60 ◽  
pp. 1-5 ◽  
Author(s):  
Daniel Antonio de Luis ◽  
David Primo ◽  
Olatz Izaola ◽  
Emilia Gomez Hoyos ◽  
Juan Jose Lopez Gomez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Hypocaloric Diet ◽  
Adiponectin Gene ◽  
The Mediterranean
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