Brilliant Agent Orange

Author(s):  
Melvin Hector
Keyword(s):  
2021 ◽  
Vol 299 ◽  
pp. 113599
Author(s):  
Alexis López ◽  
Kent Sorenson ◽  
Jeffrey Bamer ◽  
Randa Chichakli ◽  
Thomas Boivin ◽  
...  

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 259-259
Author(s):  
Alexander Tward ◽  
Jonathan David Tward

259 Background: Exposure of Vietnam War Veterans to the defoliant Agent Orange (AO) has been linked to increased tumor stage of Veterans diagnosed with prostate cancer. However, information on the effect of exposure to treatment outcomes is lacking. The goal of this study was to evaluate oncologic outcomes in Veterans based on AO exposure history, accounting for known prognostic covariates not previously studied. Methods: United States military Veterans diagnosed with prostate adenocarcinoma born between the years 1930-1956 were identified from a large professionally curated institutional database. Evaluable patients had to have known AO exposure status, age, NCCN risk group, Charlson comorbidity score, smoking status, and whether initial therapy was surgical, radiation, or systemic. Risk of death, metastasis, and progression stratified by the type of initial therapy received was analyzed using Cox regression. Results: There were 70 AO exposed and 561 non-exposed Veterans identified, with a median follow-up of 10.0 years. AO exposure Veterans (AOeV) were significantly younger (64.0 versus 65.7 years, p=0.013) at diagnosis and presented at more advanced stages (e.g. Stage 4: 14.3% versus 2.5%) than non-exposed Veterans (non-AOeV). There was no difference for overall survival (HR=0.86, p=0.576, metastasis-free survival (HR=1.5, p=0.212), or progression-free survival (HR=0.67, p 0.060) between AOeV versus non-AOeV in analyses stratified by treatment received accounting for other prognostic covariates. Cigarette smoking was associated with a 2- 3-fold increased risk of death over those who quit or never smoked. Conclusions: Although AOeV do present at younger age and higher clinical stages than non-AOeV, the oncologic outcomes after accounting for treatments received and other prognostic covariates are similar. The implication is that AOeV are more likely to be recommended multimodality or systemic therapies at presentation.


2020 ◽  
Vol 23 (3) ◽  
pp. 189-205 ◽  
Author(s):  
Françoise Naudillon

The documentary film C’est ma terre by Fabrice Bouckat screened during the 2019 edition of Terrafestival is one of the first large-scale films produced locally on the crisis of the chlordecone molecule. This article will examine from a decolonial perspective, how its director, a Martinican with Gabonese origins who lives and works in Guadeloupe, develops a synthetic and universal vision of environmental crises, and thus demonstrates that destruction of ecosystems crosses time and space, cultures and lands, languages and peoples by bringing ecological crisis in the West Indies closer to the one experienced by the Vietnamese victims of Agent Orange.


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