The Healthy, Aging, and Diseased Kidney: Relationship with Cardiovascular Disease

2020 ◽  
Author(s):  
Ramez Morcos ◽  
Ira Lazar ◽  
Michael Kucharik ◽  
Arye Lavin ◽  
Andrew Fahmy ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Healthy Aging ◽  
Diseased Kidney

scholarly journals Anti-Inflammatory Properties of Diet: Role in Healthy Aging

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 922
Author(s):  
Kristine Stromsnes ◽  
Angela G. Correas ◽  
Jenny Lehmann ◽  
Juan Gambini ◽  
Gloria Olaso-Gonzalez
Keyword(s):  
Cardiovascular Disease ◽  
Autoimmune Disease ◽  
Neurological Disease ◽  
Healthy Aging ◽  
Dietary Guidelines ◽  
The Body ◽  
Inflammatory Activity ◽  
Allergic Reactions ◽  
Inflammatory Processes ◽  
Anti Inflammatory

Inflammation is a physiological process involved in the defenses of the body and the repair of tissues. It is acutely activated by infections, trauma, toxins, or allergic reactions. However, if it becomes chronic, inflammation can end up stimulating the development of diseases such as cardiovascular disease, autoimmune disease, neurological disease, or cancer. Additionally, during aging, inflammation becomes increasingly more chronic. Furthermore, we found that certain foods, such as saturated fats, have pro-inflammatory activity. Taking this into account, in this review we have discussed different diets with possible anti-inflammatory activity, the commonly ingested components of each diet and their active compounds. In addition, we have proposed some dietary guidelines, as well as a list of compounds present in foods with anti-inflammatory activity, outlining how to combine them to achieve optimal anti-inflammatory effects. Therefore, we can conclude that the compounds in our diet with anti-inflammatory activity could help alleviate the inflammatory processes derived from diseases and unhealthy diets, and thereby promote healthy aging.

Abstract P531: FOXO3 , a Cardiovascular Protector, is at the Hub of a 46-gene Cell Resilience “Gene Factory” on Human Chromosome 6

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Brian J Morris ◽  
Timothy A Donlon ◽  
Randi Chen ◽  
Kamal H Masaki ◽  
Richard C Allsopp ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cell Lines ◽  
Binding Sites ◽  
Healthy Aging ◽  
Nutrient Sensing ◽  
Physical Contact ◽  
Ctcf Binding ◽  
Lymphoblastoid Cell Lines ◽  
Chromosome 6 ◽  
Disease Etiology

The transcription factor FoxO3 regulates multiple genes involved in cell resilience. We have previously implicated variation in non-coding DNA of the FoxO3 gene ( FOXO3 ) with lower blood pressure, reduced inflammation, less hypertension, reduced coronary heart disease mortality, and longevity. The aim of the present study was to determine transcriptional, genetic and genomic mechanisms involving FOXO3 . By DNA sequencing of chromosome 6q21 in lymphoblastoid cell lines of 95 men who had survived to ≥ 95 years of age we identified 110 FOXO3 single nucleotide polymorphisms (SNPs). Thirteen SNPs were at binding sites for 18 transcription factors. Those SNPs appeared to be in physical contact, via RNA polymerase II binding chromatin looping, with sites in the FOXO3 promoter, and likely function together as a cis -regulatory unit. At the chromosome level, FOXO3 was located at the center of a 7.3 Mb 46-gene chromatin domain flanked by gene deserts. We identified distant contact points between FOXO3 and these 46 neighboring genes, through long-range physical contacts via CCCTC-binding factor zinc finger protein (CTCF) binding sites. The genes in this “archipelago” of neighbourhood genes mediate a similar repertoire of functions as FoxO3, including stress resistance, nutrient sensing, cell proliferation, autophagy, apoptosis and stem cell maintenance. The 7.3 Mb gene domain was highly conserved across species, indicating evolutionary importance. We believe that FOXO3 serves as the hub for an “interactome” involved in healthy aging, including cardiovascular disease reduction, in those with favorable FOXO3 genotypes. In support, we found that cellular stress (H 2 O 2 ) could stimulate FOXO3 expression in 20 lymphoblastoid cell lines, being 3-fold stronger for those with a favorable FOXO3 genotype. In FISH experiments, stress-induced activation of FOXO3 caused it to move towards its neighboring genes as suggested by our genomic data. In conclusion, we have shown, for the first time, that FOXO3 is at the central hub of a gene network on chromosome 6 involved in cell protection and healthy aging. The concept of “gene factories” may apply more broadly to genome and genetic mechanisms involved in cardiovascular disease etiology.

scholarly journals “We understand our community”: implementation of the Healthy Eating Healthy Aging program among community-based organizations

2020 ◽  
Author(s):  
Judy Leong ◽  
Sou Hyun Jang ◽  
Sonia K Bishop ◽  
Emily V R Brown ◽  
Eun Jeong Lee ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Healthy Eating ◽  
Healthy Aging ◽  
Successful Implementation ◽  
Evidence Based ◽  
Semistructured Interview ◽  
Community Based ◽  
Community Based Organizations ◽  
Outer Setting ◽  
Inner Setting

Abstract Cardiovascular disease is the second leading cause of death in the USA among Asian Americans and Pacific Islanders (AAPIs) over the age of 65. Healthy Eating Healthy Aging (HEHA), an evidence-based heart health program, can provide culturally appropriate nutrition education to decrease the risk of cardiovascular disease. Community-based organizations (CBOs) are optimal settings to implement community-based programs. However, there is inadequate research on how evidence-based interventions like HEHA are implemented in CBOs. This study examined processes that facilitated the implementation of HEHA among CBOs serving older AAPIs. Twelve representatives from CBOs that implemented the HEHA program were recruited to participate in a semistructured interview. All the participants were CBO directors or senior managers. A semistructured interview guide was created and informed by the Consolidated Framework for Implementation Research (CFIR) to capture how HEHA played into the five domains of CFIR: (a) intervention characteristics, (b) outer setting, (c) inner setting, (d) characteristics of the individuals, and (e) process. Data analysis captured themes under the CFIR domains. All five CFIR domains emerged from the interviews. Under intervention characteristics, three constructs emerged as facilitating the implementation of HEHA: (a) the participant’s beliefs around the quality of the HEHA program and its ability to promote healthy eating, (b) HEHA’s adaptability to different AAPI subgroups, and (c) perceptions of how successfully HEHA was bundled and assembled. Under outer setting, the participants described the community’s need for healthy eating programs and how the HEHA program meets that need. Four constructs emerged under inner setting: (a) the CBO’s structural characteristics and social standing in the community; (b) resources dedicated to the implementation and ongoing operations, including funding, training, education, physical space, and time; (c) the culture of the CBO; and (d) the participant’s commitment and involvement in marketing, promotion, and implementation of HEHA. Under characteristics of individuals, participants’ described their desire to learn the content of HEHA and deliver them successfully. Under process, participants described strategies to engage relevant individuals to facilitate HEHA implementation. The interviews with CBO representatives provided insights into CFIR domain constructs that facilitated the implementation of HEHA. CBOs are key settings for community health education. Understanding processes that lead to the successful implementation of evidence-based interventions among CBOs is critical for accelerating the dissemination and implementation of best practices.

Abstract 163: The Prevalence of the Metabolically Healthy Obese Phenotype in an Aging Population and its Association with Subclinical Cardiovascular Disease: The Brazilian Study on Healthy Aging

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Lara L Roberson ◽  
Shozab A Siddiqui ◽  
Michael J Blaha ◽  
Arthur A Agatston ◽  
Roger S Blumenthal ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Waist Circumference ◽  
Healthy Aging ◽  
Subclinical Atherosclerosis ◽  
Aging Population ◽  
Normal Weight ◽  
Metabolically Healthy Obese ◽  
Subclinical Cardiovascular Disease ◽  
Healthy Obese ◽  
Metabolically Healthy

BACKGROUND Obese and overweight individuals have been shown to be at higher risk of CVD events than normal weight individuals. Current literature has elucidated a new phenotype, Metabolically Healthy Obese (MHO), with risks of CVD similar to that of normal weight individuals. Few studies have examined the MHO phenotype in an aging population, especially in association with subclinical cardiovascular disease. METHODS The cross sectional study population consisted of 208 individuals (79% Female), age 80 and older (mean age 84±4, range 80-102). Anthropometrics & biochemical parameters were measured. The Adult Treatment Panel definition of metabolic syndrome (MetS), excluding waist circumference, criteria was used to define metabolically healthy (<3 MetS components) versus unhealthy. A combination of BMI and waist circumference were used to define normal weight and overweight/obese. Multidetector-row cardiac CT for coronary artery calcium score (CACS) was used to detect subclinical atherosclerosis. High reactive C reactive protein (hs-CRP) was measured to assess degree of underlying inflammation. RESULTS The prevalence of MHO defined by BMI≥25 kg/m2 &/or waist circumference >88cm in women, >102cm in men & having 3mg/dl, Uric Acid >6 mg/dl (p=NS). Gender, total cholesterol, HDL, LDL, triglycerides, and SBP was significantly associated with MHO (p<0.05). CONCLUSIONS Our results suggest that the MHO phenotype is still seen in octogenarians, but at lower rates than in the general population suggesting MHO may not simply be an intermediary stage, driven by length of spent in the obese state. Those with this phenotype tended to have lower triglycerides, higher HDL, and lower body fat % than their metabolically at risk obese counterparts (p<0.05), however, degree of subclinical CVD was not different. Further studies are needed to explore the related risk of CVD among MHO octogenarians.

scholarly journals Platelets in aging and cancer—“double-edged sword”

2020 ◽  
Vol 39 (4) ◽  
pp. 1205-1221 ◽  
Author(s):  
Alessandra V. S. Faria ◽  
Sheila S. Andrade ◽  
Maikel P. Peppelenbosch ◽  
Carmen V. Ferreira-Halder ◽  
Gwenny M. Fuhler
Keyword(s):  
Cardiovascular Disease ◽  
Cancer Progression ◽  
Healthy Aging ◽  
Great Majority ◽  
Platelet Activity ◽  
The Road ◽  
Anti Platelet Therapy ◽  
Age Related ◽  
Cell Metastasis ◽  
Thrombotic Diseases

AbstractPlatelets control hemostasis and play a key role in inflammation and immunity. However, platelet function may change during aging, and a role for these versatile cells in many age-related pathological processes is emerging. In addition to a well-known role in cardiovascular disease, platelet activity is now thought to contribute to cancer cell metastasis and tumor-associated venous thromboembolism (VTE) development. Worldwide, the great majority of all patients with cardiovascular disease and some with cancer receive anti-platelet therapy to reduce the risk of thrombosis. However, not only do thrombotic diseases remain a leading cause of morbidity and mortality, cancer, especially metastasis, is still the second cause of death worldwide. Understanding how platelets change during aging and how they may contribute to aging-related diseases such as cancer may contribute to steps taken along the road towards a “healthy aging” strategy. Here, we review the changes that occur in platelets during aging, and investigate how these versatile blood components contribute to cancer progression.

scholarly journals Association of an Index of Healthy Aging With Incident Cardiovascular Disease and Mortality in a Community-Based Sample of Older Adults

2016 ◽  
Vol 71 (12) ◽  
pp. 1695-1701 ◽  
Author(s):  
Elizabeth L. McCabe ◽  
Martin G. Larson ◽  
Kathryn L. Lunetta ◽  
Anne B. Newman ◽  
Susan Cheng ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Older Adults ◽  
Healthy Aging ◽  
Community Based ◽  
Incident Cardiovascular Disease

Polyphenols effect on cerebrovascular health

2021 ◽  
Vol 28 ◽  
Author(s):  
Luis Goya ◽  
Ricardo San Román ◽  
Sonia de Pascual-Teresa
Keyword(s):  
Cardiovascular Disease ◽  
Blood Flow ◽  
Disease Prevention ◽  
Beneficial Effect ◽  
Healthy Aging ◽  
Pharmacological Effects ◽  
Cerebrovascular Health ◽  
Wide Group ◽  
Radiological Methods ◽  
Plant Components

: Polyphenols are a wide group of plant components that include a high number of individual compounds and are present in foods, dietary supplements and drugs. Many of them have shown pharmacological effects, are used in cardiovascular disease prevention, and not as many have been assayed in cancer treatment or co-treatment. In the last few years, however, the research on polyphenols implications in a healthy aging and especially in neurodegeneration and cognition improvement has increased dramatically. Most of the results found in this sense are again related with the capacity of some specific polyphenols to regulate the blood flow, but this time at the cerebral level, and to protect the endothelium at this same level. In this thorough review, we want to concentrate precisely on the effect of polyphenols on the cerebrovascular homeostasis, reviewing the mechanisms that underline this effect and the radiological methods and endogenous biomarkers that are used in human trials aimed at showing the beneficial effect of polyphenols or polyphenols rich foods on neuroprotection and cognition function.

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