scholarly journals High‐Sensitive Troponin T, Natriuretic Peptide, and Cognitive Change

2019 ◽  
Vol 67 (11) ◽  
pp. 2353-2361 ◽  
Author(s):  
Yashashwi Pokharel ◽  
Farah Mouhanna ◽  
Andrea L. C. Schneider ◽  
Andreea M. Rawlings ◽  
David S. Knopman ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Troponin T ◽  
Cognitive Change ◽  
High Sensitive Troponin

scholarly journals Preoperative Cerebral Oxygen Saturation and Clinical Outcomes in Cardiac Surgery

2011 ◽  
Vol 114 (1) ◽  
pp. 58-69 ◽  
Author(s):  
Matthias Heringlake ◽  
Christof Garbers ◽  
Jan-Hendrik Käbler ◽  
Ingrid Anderson ◽  
Hermann Heinze ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Oxygen Saturation ◽  
Clinical Outcomes ◽  
Natriuretic Peptide ◽  
Troponin T ◽  
Area Under The Curve ◽  
Cerebral Oxygen Saturation ◽  
Cerebral Oxygen ◽  
Mortality And Morbidity ◽  
High Sensitive Troponin

Background The current study was designed to determine the relation between preoperative cerebral oxygen saturation (Sco2), variables of cardiopulmonary function, mortality, and morbidity in a heterogeneous cohort of cardiac surgery patients. Methods In this study, 1,178 consecutive patients scheduled for on-pump surgery were prospectively studied. Preoperative Sco2, demographics, N-terminal pro-B-type natriuretic peptide, high-sensitive troponin T, clinical outcomes, and 30-day and 1-yr mortality were recorded. Results Median additive EuroSCORE was 5 (range: 0-19). Thirty-day and 1-yr mortality and major morbidity (at least two major complications and/or a high-dependency unit stay of at least 10 days) were 3.5%, 7.7%, and 13.3%, respectively. Median minimal preoperative oxygen supplemented Sco2 (Sco2min-ox) was 64% (range: 15-92%). Sco2min-ox was correlated (all: P value <0.0001) with N-terminal pro-B-type natriuretic peptide (ρ: -0.35), high-sensitive troponin T (ρ: -0.28), hematocrit (ρ: 0.34), glomerular filtration rate (ρ: 0.19), EuroSCORE (τ: 0.20), and left ventricular ejection fraction class (τ: 0.12). Thirty-day nonsurvivors had a lower Sco2min-ox than survivors (median 58% [95% CI, 50.7-62%] vs. 64% [95% CI, 64-65%]; P < 0.0001). Receiver-operating curve analysis of Sco2min-ox and 30-day mortality revealed an area-under-the-curve of 0.71 (95% CI, 0.68-0.73%; P < 0.0001) in the total cohort and an area-under-the-curve of 0.77 (95% CI, 0.69-0.86%; P < 0.0001) in patients with a EuroSCORE more than 10. Logistic regression based on different EuroSCORE categories (0-2; 3-5, 6-10, >10), Sco2min-ox, and duration of cardiopulmonary bypass showed that a Sco2min-ox equal or less than 50% is an independent risk factor for 30-day and 1-yr mortality. Conclusions Preoperative Sco2 levels are reflective of the severity of cardiopulmonary dysfunction, associated with short- and long-term mortality and morbidity, and may add to preoperative risk stratification in patients undergoing cardiac surgery.

Distribution of soluble suppression of tumorigenicity 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitive troponin I and high-sensitive troponin T in umbilical cord blood

2016 ◽  
Vol 54 (11) ◽  
Author(s):  
Hanah Kim ◽  
Ji Myung Kim ◽  
Mina Hur ◽  
Mi-Kyung Park ◽  
Hee-Won Moon ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Cord Blood ◽  
Natriuretic Peptide ◽  
Umbilical Cord Blood ◽  
Apgar Score ◽  
Troponin I ◽  
Troponin T ◽  
Cardiac Markers ◽  
Term Neonates ◽  
High Sensitive Troponin

AbstractBackground:Soluble suppression of tumorigenicity 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitive troponin I (hs-TnI), and high sensitive troponin T (hs-TnT) are representative cardiac biomarkers. The reference intervals (RIs) of these biomarkers have been rarely investigated in umbilical cord blood (UCB). We explored the distribution of these cardiac markers and established their RIs in UCB.Methods:In a total of 293 UCB specimens, sST2, NT-proBNP, hs-TnI, and hs-TnT concentrations were analyzed according to the gestational age, presence of premature membrane rupture (PROM), presence of gestational diabetes mellitus (GDM), and Apgar score at 1 min. Their RIs were defined in 133 UCB specimens from healthy, full-term neonates, using non-parametric percentile methods according to the Clinical and Laboratory Standards Institute guideline (EP28-A3C).Results:The concentrations of four cardiac markers in UCB were different between full-term neonates and pre-term neonates. The concentrations of NT-proBNP and hs-TnI differed according to the presence or absence of PROM. Their concentrations did not differ regardless of the presence of GDM. The concentrations of sST2 and NT-proBNP differed according to the Apgar score at 1 min. The 97.5th percentile upper reference limits were: sST2, 59.9 ng/mL; NT pro-BNP, 1415.3 pg/mL; hs-TnI, 27.8 pg/mL; and hs-TnT, 86.5 pg/mL.Conclusions:The distribution of sST2, NT pro-BNP, hs-TnI, and hs-TnT in UCB together with their RIs would provide fundamental data for future researches and clinical practice.

High-sensitive troponin T and N-terminal-brain-natriuretic-peptide predict outcome in symptomatic aortic stenosis

2012 ◽  
Vol 46 (5) ◽  
pp. 278-285 ◽  
Author(s):  
Ole Geir Solberg ◽  
Thor Ueland ◽  
Ragnhild Wergeland ◽  
Christen P. Dahl ◽  
Svend Aakhus ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Troponin T ◽  
High Sensitive Troponin

scholarly journals Associations of brain–natriuretic peptide, high–sensitive troponin T, and high–sensitive C–reactive protein with outcomes in severe aortic stenosis

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179304 ◽  
Author(s):  
Andreas Auensen ◽  
Amjad Iqbal Hussain ◽  
Ragnhild Sørum Falk ◽  
Marte Meyer Walle-Hansen ◽  
Jorun Bye ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Troponin T ◽  
Severe Aortic Stenosis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
High Sensitive Troponin
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