Effect of Monthly High-Dose Vitamin D on Mental Health in Older Adults: Secondary Analysis of a RCT

2019 ◽  
Vol 67 (6) ◽  
pp. 1211-1217 ◽  
Author(s):  
Alenka Gugger ◽  
Alex Marzel ◽  
E. John Orav ◽  
Walter C. Willett ◽  
Bess Dawson-Hughes ◽  
...  
Keyword(s):  
Mental Health ◽  
Older Adults ◽  
Vitamin D ◽  
Secondary Analysis ◽  
High Dose ◽  
High Dose Vitamin

scholarly journals 70 High Dose Vitamin D for the Prevention of Wheezing in Preschoolers: A Secondary Analysis of a Randomized Clinical Trial

2019 ◽  
Vol 24 (Supplement_2) ◽  
pp. e27-e28 ◽  
Author(s):  
Mary Aglipay ◽  
Catherine Birken ◽  
David Dai ◽  
Patricia Parkin ◽  
Jonathon Maguire
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Randomized Clinical Trial ◽  
Secondary Analysis ◽  
High Dose ◽  
High Dose Vitamin

Effect of Monthly High-Dose Vitamin D Supplementation on Acute Respiratory Infections in Older Adults: A Randomized Controlled Trial

2019 ◽  
Vol 71 (2) ◽  
pp. 311-317 ◽  
Author(s):  
Carlos A Camargo ◽  
John Sluyter ◽  
Alistair W Stewart ◽  
Kay-Tee Khaw ◽  
Carlene M M Lawes ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Clinical Trials ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Randomized Controlled ◽  
Increased Risk ◽  
High Dose Vitamin

Abstract Background Although adults with low vitamin D status are at increased risk of acute respiratory infection (ARI), randomized controlled trials of vitamin D supplementation have provided inconsistent results. Methods We performed a randomized, double-blinded, placebo-controlled trial of 5110 adults aged 50–84 years. In 2011–2012, participants were randomized to an initial oral dose of 200 000 IU vitamin D3 followed by 100 000 IU monthly (n = 2558) or placebo (n = 2552) until late 2013 (median follow-up, 1.6 years). Participants reported upper and lower ARIs on monthly questionnaires. Cox models analyzed time to first ARI (upper or lower) by treatment group. Results Participants’ mean age was 66 years and 58% were male; 83% were of European/other ethnicity, with the rest Maori, Polynesian, or South Asian. Mean (SD) baseline blood 25-hydroxyvitamin D [25(OH)D] level was 63 (24) nmol/L; 25% were <50 nmol/L. In a random sample (n = 441), vitamin D supplementation increased mean 25(OH)D to 135 nmol/L at 3 years, while those on placebo remained at 63 nmol/L. During follow-up, 3737 participants reported ≥1 ARI: 74.1% in the vitamin D group versus 73.7% in the placebo group. The hazard ratio for vitamin D compared with placebo was 1.01 (95% CI, 0.94, 1.07). Similar results were seen in most subgroups, including those with baseline 25(OH)D <50 nmol/L and in analyses of the upper/lower components of the ARI outcome. Conclusions Monthly high-dose vitamin D supplementation does not prevent ARI in older adults with a low prevalence of profound vitamin D deficiency at baseline. Whether effects of daily or weekly dosing differ requires further study. Clinical Trials Registration Australian New Zealand Clinical Trials Registry, identifier ACTRN12611000402943.

scholarly journals Postural Balance Effects Associated with 400, 4000 or 10,000 IU Vitamin D3 Daily for Three Years: A Secondary Analysis of a Randomized Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 527 ◽  
Author(s):  
Lauren A. Burt ◽  
Leigh Gabel ◽  
Emma O. Billington ◽  
David A. Hanley ◽  
Steven K. Boyd
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D3 ◽  
Postural Sway ◽  
Secondary Analysis ◽  
Vitamin D Supplementation ◽  
Community Dwelling ◽  
High Dose ◽  
Eyes Closed ◽  
Eyes Open

Vitamin D supplementation is proposed as a fall prevention strategy, as it may improve neuromuscular function. We examined whether three years of vitamin D supplementation (400, 4000 or 10,000 IU daily) affects postural sway in older adults. Three hundred and seventy-three non-osteoporotic, vitamin D-sufficient, community-dwelling healthy adults, aged 55–70 years, were randomized to 400 (n = 124), 4000 (n = 125) or 10,000 (n = 124) IU daily vitamin D3 for three years. Sway index was assessed at baseline, 12-, 24- and 36-months using the Biosway machine. We tested participants under four conditions: eyes open or eyes closed with firm (EOFI, ECFI) or foam (EOFO, ECFO) surfaces. Secondary assessments examined sway in the anterior-posterior (AP) and medio-lateral (ML) directions. Linear mixed effects models compared sway between supplementation groups across time. Postural sway under EOFO and ECFO conditions significantly improved in all supplementation groups over time. Postural sway did not differ between supplementation groups at any time under any testing conditions in normal, AP or ML directions (p > 0.05 for all). Our findings suggest that high dose (4000 or 10,000 IU) vitamin D supplementation neither benefit nor impair balance compared with 400 IU daily in non-osteoporotic, vitamin D-sufficient, healthy older adults.

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