Circulating serum level of retinoic acid and hip fractures among postmenopausal women

2018 ◽  
Vol 67 (2) ◽  
pp. 336-341 ◽  
Author(s):  
Xiao-Bin Li ◽  
Tao Liu ◽  
Lei Fan ◽  
Qiang Gao ◽  
Qiang Peng ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Serum Level ◽  
Postmenopausal Women ◽  
Hip Fractures

scholarly journals Comparison between NAFLD fibrosis score and retinoic acid serum level in NAFLD

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ahmed Samir Allam ◽  
Mohamed Magdy Salama ◽  
Haytham Mohamed Nasser ◽  
Walaa Ahmed Yousry Kabiel ◽  
Ehab H. Elsayed
Keyword(s):  
Retinoic Acid ◽  
Serum Level ◽  
Fibrosis Score ◽  
Nafld Fibrosis Score

The Clinical Use of Denosumab for the Management of Low Bone Mineral Density in Postmenopausal Women

2012 ◽  
Vol 25 (3) ◽  
pp. 310-318 ◽  
Author(s):  
Kira B. Harris ◽  
Kimberly L. Nealy ◽  
Delilah J. Jackson ◽  
Phillip L. Thornton
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Hip Fractures ◽  
Nuclear Factor Κb ◽  
Bisphosphonate Therapy ◽  
Mineral Density ◽  
Osteoporosis Therapy ◽  
Cost Of Health Care ◽  
Therapy Studies

Osteoporosis is a leading cause of debility and declining quality of life in postmenopausal women worldwide. Treatment of osteoporosis has been ubiquitous throughout the developed world since the mid-1990s, most notably with the introduction of bisphosphonates in 1995. Nonetheless, the incidence of hip fractures increased by 25% between 1990 and 2000, despite advances in osteoporosis therapy. Studies indicate that bone density increases over the first 3 years of bisphosphonate therapy and then plateaus or perhaps even declines, placing these patients at greater risk of fracture. Since hip fractures are associated with increased morbidity, mortality, and increased cost of health care, improvements in treating osteoporosis are critical. Denosumab is a novel monoclonal antibody targeted against the receptor activator of nuclear factor-κB ligand (RANKL) that inhibits osteoclast activity. Initial data suggest that denosumab increases bone mineral density for greater than 3 years. Of greater importance, denosumab has been shown to decrease vertebral fractures by 68%, nonvertebral fractures by 19%, and hip fractures by 42% for at least 36 months. Data also indicate that the safety profile of denosumab is equivalent to other drugs used in osteoporosis management, but potential risks of immunosuppression and cancer have been hypothesized.

scholarly journals Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1139
Author(s):  
Ewelina Anna Dziedzic ◽  
Wiktor Smyk ◽  
Izabela Sowińska ◽  
Marek Dąbrowski ◽  
Piotr Jankowski
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Risk Factor ◽  
Coronary Artery ◽  
Serum Level ◽  
Postmenopausal Women ◽  
Coronary Atherosclerosis ◽  
History Of ◽  
Artery Disease ◽  
The Impact

Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. Material and Methods: The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. Results: Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level (p = 0.0001). Vitamin D (β = −0.02; p = 0.016), hypertension (β = 0.44; p = 0.025), age (β = 0.02; p = 0.003), and history of MI (β = 0.63; p < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all p < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. Conclusions: Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.

scholarly journals Soda consumption and the risk of hip fractures in postmenopausal women (1027.6)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Teresa Fung ◽  
Meredith Arasaratnam ◽  
Francine Grodstein ◽  
Jeffrey Katz ◽  
Bernard Rosner ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Hip Fractures ◽  
Soda Consumption

Study of the incremental cost and clinical burden of hip fractures in postmenopausal women in the United Kingdom

2011 ◽  
Vol 14 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Lia Gutiérrez ◽  
Neil Roskell ◽  
Jordi Castellsague ◽  
Stephen Beard ◽  
Catherine Rycroft ◽  
...  
Keyword(s):  
United Kingdom ◽  
Incremental Cost ◽  
Postmenopausal Women ◽  
Hip Fractures ◽  
The United Kingdom ◽  
Clinical Burden

scholarly journals Random field assessment of inhomogeneous bone mineral density from DXA scans can enhance the differentiation between postmenopausal women with and without hip fractures

2015 ◽  
Vol 48 (6) ◽  
pp. 1043-1051 ◽  
Author(s):  
Xuanliang Neil Dong ◽  
Rajeshwar Pinninti ◽  
Timothy Lowe ◽  
Patricia Cussen ◽  
Joyce E. Ballard ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Random Field ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Hip Fractures ◽  
Mineral Density ◽  
Field Assessment ◽  
Dxa Scans

Potential role of FRAX analysis in postmenopausal women with osteopenia

Open Medicine ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. 185-189
Author(s):  
Aleksandar Dimić ◽  
Stojanovic Sonja ◽  
Nedovic Jovan ◽  
Stankovic Aleksandra ◽  
Stamenkovic Bojana ◽  
...  
Keyword(s):  
Hip Fracture ◽  
High Risk ◽  
Postmenopausal Women ◽  
Hip Fractures ◽  
Potential Role ◽  
Osteoporotic Fractures ◽  
Significant Negative Correlation ◽  
Mineral Density ◽  
Fracture Development

AbstractEarly diagnosis of osteoporosis and estimation of subjects that are at high risk for fracture, is neccesary for osteoporosis treatment. Dual-energy X-ray absorptometry (DXA) is a modern method for bone mineral density (BMD) evaluation. However, along BMD, clinical risk factors may significantly influence fracture development. Therefore, FRAX algorithm was designed for the assessment of a ten-year risk for serious osteoporotic fractures (SOF), as well as hip fractures. In the current study, we tried to evaluate the possible lumbal spine and hip BMD influence on ten year risk for SOF and hip fractures and potential role of FRAX in predicting the therapy in postmenopausal women with osteopenia. We performed the study on 385 postmenopausal women. According to the DXA measurements, at the lumbal (L) spine (L1–L4) and hip (femor neck), patients were then classified as normal, osteopenic, or osteoporotic. BMD evaluation included the L spine and the hip (subgroup 1), and only on the L spine (subgroup 2). By filling up the FRAX questionnaire, a ten-year risk for SOF fracture and hip fracture was calculated. BMD evaluation, in complete patient’s group and in subgroup 1, resulted in the highest number of osteoporosis (61.04%, 48.08%, retrospectively), while ospeopenia was a main finding in subgroup 2. In the subgroup 1, a high risk for SOF and hip fracture was detected in 16.45% and with high risk for hip fracture in 11.38% subjects. In subgroup 2, only high risk for hip fracture was observed in 3.16% subjects, indicating the active medicament treatment. Simultaneously, correlation of BMD results with FRAX values for SOF and hip fracture, showed significant negative correlation (p<0.001). Obtained results showed significant role of femur neck BMD evaluation in predicting the future factors, which may, together with FRAX analysis, improve the therapy approach in postmenopausal women with ospeopenia.

Meta-analysis of the efficacy of alendronate for the prevention of hip fractures in postmenopausal women

2004 ◽  
Vol 16 (5) ◽  
pp. 468-474 ◽  
Author(s):  
Socrates E. Papapoulos ◽  
Sara A. Quandt ◽  
Uri A. Liberman ◽  
Marc C. Hochberg ◽  
Desmond E. Thompson
Keyword(s):  
Postmenopausal Women ◽  
Hip Fractures ◽  
Meta Analysis
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