Effect of Statin Therapy on Mortality in Older Adults Hospitalized with Coronary Artery Disease: A Propensity-Adjusted Analysis

2016 ◽  
Vol 64 (7) ◽  
pp. 1475-1479 ◽  
Author(s):  
Daniel P. Rothschild ◽  
Eric Novak ◽  
Michael W. Rich
Keyword(s):  
Older Adults ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Statin Therapy ◽  
Adjusted Analysis ◽  
Artery Disease

Eicosapentaenoic Acid Combined with Optimal Statin Therapy Improves Endothelial Dysfunction in Patients with Coronary Artery Disease

2013 ◽  
Vol 28 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Kentaro Toyama ◽  
Toshihiko Nishioka ◽  
Ami Isshiki ◽  
Toshiyuki Ando ◽  
Yoshiro Inoue ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Dysfunction ◽  
Eicosapentaenoic Acid ◽  
Statin Therapy ◽  
Artery Disease

CYP3A4 *1B Gene Polymorphism in Coronary Artery Disease Patients with Obesity Undergoing Statin Treatment

2021 ◽  
Vol 18 ◽  
Author(s):  
Elifcan Gezer ◽  
Mehtap Cevik ◽  
Cansu Selcan Akdeniz ◽  
Ismail Polat Canbolat ◽  
Selen Yurdakul ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Statin Therapy ◽  
Plasma Lipid ◽  
Blood Cholesterol ◽  
Study Group ◽  
Genotype Distribution ◽  
Obese Patients ◽  
Artery Disease

Objective: Coronary artery disease (CAD) is the one of the leading cause of morbidity and mortality worldwide and statins are frequently prescribed in the treatment of CAD to help lower blood cholesterol levels. Since the main enzyme involved in the metabolism of statins is CYP3A4, we aimed to investigate the effect of CYP3A4 * 1B genotypes on plasma lipid profile in Turkish cardiovascular disease subject with and without obesity taking statin. Materials and Methods: The study group consisted of 85 cardiovascular disease patients who were prescribed statins and had routine biochemical analysis data. Polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) assay were performed for genotyping of CYP3A4 *1B (rs2740574) polymorphism. Results: Genotype distribution of CYP3A4 *1B polymorphism was found for homozygous wild (AA) and homozygous polymorphic (GG) genotypes as 94.1% and 5.9% respectively. We did not detect patients with heterozygous genotype in our study group. We found that the mean LDL-c, TG and TC levels were higher in patients with CYP3A4 *1B GG compared to AA genotype. The frequency of CYP3A4 *1B GG genotype frequency (9.5%) was detected higher in the obese patients compared to the non-obese patients (7.7%) (χ2=0.037, p=0.85). Conclusions: Our results demonstrate that CYP3A4 *1B homozygous polymorphic genotype distribution tend to be higher in obese patients compared to non- obese patients with cardiovascular disease which may point *1B allele to have a slight effect on serum lipids during statin therapy. Additional studies with higher samples are needed for evaluating the role of CYP3A4 *1B on lipids in patients under statin therapy.

Very long-term outcomes of older adults with stable coronary artery disease (from the CORONOR study)

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Abou-bakr Abbadi ◽  
Gilles Lemesle ◽  
Nicolas Lamblin ◽  
Christophe Bauters
Keyword(s):  
Older Adults ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Stable Coronary Artery Disease ◽  
Long Term Outcomes ◽  
Artery Disease

scholarly journals Chronic Adaptations On The Oxygen Uptake Kinetics In Trained Older Adults With Coronary Artery Disease

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 257
Author(s):  
Rita Pinto ◽  
Joana Reis ◽  
Vitor Angarten ◽  
Madalena Lemos Pires ◽  
Mariana Borges ◽  
...  
Keyword(s):  
Older Adults ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Oxygen Uptake ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Artery Disease
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