scholarly journals Immunosuppressive Therapy (Methotrexate or Cyclophosphamide) in Combination with Corticosteroids in the Treatment of Giant Cell Arteritis: Comparison with Corticosteroids Alone

2016 ◽  
Vol 64 (3) ◽  
pp. 672-374 ◽  
Author(s):  
Angela Carbonella ◽  
Giorgia Berardi ◽  
Luca Petricca ◽  
Federico Biscetti ◽  
Stefano Alivernini ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Immunosuppressive Therapy ◽  
Giant Cell ◽  
Therapy Methotrexate

Lethal giant cell arteritis with multiple ischemic strokes despite aggressive immunosuppressive therapy

2010 ◽  
Vol 295 (1-2) ◽  
pp. 120-124 ◽  
Author(s):  
Christine Lu-Emerson ◽  
Melanie Walker ◽  
Bertrand R. Huber ◽  
Basavaraj Ghodke ◽  
W.T. Longstreth, ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Immunosuppressive Therapy ◽  
Giant Cell

THU0270 Immunosuppressive Therapy in Combination with Steroids in the Treatment of Giant Cell Arteritis

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 294.2-294
Author(s):  
A. Carbonella ◽  
G. Berardi ◽  
F. Biscetti ◽  
S.L. Bosello ◽  
F. Parisi ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Immunosuppressive Therapy ◽  
Giant Cell

A subcutaneous fluid collection after the Bentall procedure in a female patient with giant cell arteritis

2018 ◽  
Vol 56 (2) ◽  
pp. 412-414
Author(s):  
Samantha Guimaron ◽  
Jean-François Heautot ◽  
Bérangère Cador-Rousseau ◽  
Jean-Philippe Verhoye
Keyword(s):  
Giant Cell Arteritis ◽  
Immunosuppressive Therapy ◽  
Giant Cell ◽  
Female Patient ◽  
Surgical Approach ◽  
Fluid Collection ◽  
Infectious Complications ◽  
Bentall Procedure ◽  
Pulsatile Mass ◽  
History Of

Abstract We report a 61-year-old woman with a history of untreated inflammatory symptoms, who underwent a Bentall procedure for a rapidly evolving aneurysm. Postoperatively, she presented with a sub-sternal pulsatile mass communicating with a periaortic collection. After excluding surgical and infectious complications, an inflammatory seroma due to an uncontrolled vasculitis was suspected. We proposed a non-surgical approach involving immunosuppressive therapy.

scholarly journals Associated factors of poor treatment outcomes in patients with giant cell arteritis: clinical implication of large vessel lesions

2020 ◽  
Author(s):  
Takahiko Sugihara ◽  
Hitoshi Hasegawa ◽  
Haruhito A Uchida ◽  
Hajime Yoshifuji ◽  
Yoshiko Watanabe ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Treatment Outcomes ◽  
Immunosuppressive Therapy ◽  
Giant Cell ◽  
Clinical Remission ◽  
Associated Factors ◽  
Signs And Symptoms ◽  
Large Vessel ◽  
Newly Diagnosed ◽  
Poor Treatment

Abstract Background: Relapses frequently occur in giant cell arteritis (GCA) patients treated with conventional immunosuppressive therapy, and identification of associated factors with poor treatment outcomes is relevant to adjust treatment appropriately. Methods: We enrolled 139 newly-diagnosed GCA patients treated with glucocorticoids between 2007 and 2014 in a retrospective, multi-center registry. Patients were diagnosed as having GCA with temporal artery biopsy, large-vessel lesions (LVLs) detected by imaging, 1990 American College of Rheumatology classification criteria, or combination of these. Poor treatment outcomes (non-achievement of clinical remission by week 24 or relapse during 52 weeks) were evaluated. Clinical remission was defined as absence of clinical signs and symptoms in cranial and large-vessel areas, polymyalgia rheumatica (PMR), and elevation of C-reactive protein (CRP) levels. A patient was determined to have relapse if he/she had either one of the signs and symptoms that newly appeared or worsened after achieving clinical remission. Re-elevation of CRP without clinical manifestations was considered as relapse if other causes such as infection were excluded and the treatment was intensified. Associated factors with poor treatment outcomes were analyzed by using the Cox proportional hazard model.Results: Cranial lesions, PMR, and LVLs were detected in 77.7%, 41.7%, and 52.5% of the enrolled patients, respectively. Treatment outcomes were evaluated in 119 newly-diagnosed patients who were observed for 24 weeks or longer. The mean initial dose of prednisolone was 0.76 mg/kg/day, and 29.4% received any concomitant immunosuppressive drugs at baseline. Overall, 41 (34.5%) of the 119 patients had poor treatment outcomes; 13 did not achieve clinical remission by week 24, and 28 had relapse after achieving clinical remission. Cumulative rates of the events of poor treatment outcomes in patients with and without LVLs were 47.5 % and 17.7%, respectively. A multivariable model showed the presence of LVLs at baseline was significantly associated with poor treatment outcomes (adjusted hazard ratio [HR] 3.54, 95% CI 1.52-8.24, p=0.003). Cranial lesions and PMR did not increase the risk of poor treatment outcomes. Conclusion: Presence of LVLs detected by imaging at baseline was an associated factor for poor treatment outcomes in patients given conventional immunosuppressive therapy without biologics.

Fatal giant cell arteritis of small to medium-sized visceral arteries: atypical manifestation or new entity?

VASA ◽  
2015 ◽  
Vol 44 (3) ◽  
pp. 0229-0232 ◽  
Author(s):  
Francesco Sciotto ◽  
Jörg D. Seebach ◽  
Johannes A. Lobrinus ◽  
Hala Kannuna ◽  
David Carballo ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Visceral Arteries ◽  
Atypical Manifestation
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