scholarly journals Fibroblast Growth Factor-23 and Frailty in Elderly Community-Dwelling Individuals: The Cardiovascular Health Study

2016 ◽  
Vol 64 (2) ◽  
pp. 270-276 ◽  
Author(s):  
Tomasz Beben ◽  
Joachim H. Ix ◽  
Michael G. Shlipak ◽  
Mark J. Sarnak ◽  
Linda F. Fried ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cardiovascular Health ◽  
Fibroblast Growth Factor 23 ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Fibroblast Growth

Fibroblast growth factor 23 (FGF23) and mortality: The Ludwigshafen Risk and Cardiovascular Health Study

2014 ◽  
Vol 237 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Vincent M. Brandenburg ◽  
Marcus E. Kleber ◽  
Marc G. Vervloet ◽  
Andreas Tomaschitz ◽  
Stefan Pilz ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cardiovascular Health ◽  
Fibroblast Growth Factor 23 ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Fibroblast Growth

scholarly journals Sleep disordered breathing and fibroblast growth factor 23 in the Hispanic Community Health Study/Study of Latinos

Bone ◽  
2018 ◽  
Vol 114 ◽  
pp. 278-284 ◽  
Author(s):  
Rupal Mehta ◽  
Xuan Cai ◽  
Alexander Hodakowski ◽  
Bharat Thyagarajan ◽  
Donglin Zeng ◽  
...  
Keyword(s):  
Growth Factor ◽  
Community Health ◽  
Fibroblast Growth Factor ◽  
Sleep Disordered Breathing ◽  
Fibroblast Growth Factor 23 ◽  
Health Study ◽  
Fibroblast Growth ◽  
Hispanic Community ◽  
Disordered Breathing

scholarly journals Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women

2011 ◽  
Vol 165 (5) ◽  
pp. 797-803 ◽  
Author(s):  
Mansi Dalal ◽  
Kai Sun ◽  
Anne R Cappola ◽  
Luigi Ferrucci ◽  
Candace Crasto ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Elevated Serum ◽  
Community Dwelling ◽  
Fibroblast Growth ◽  
Multivariable Logistic Regression Model ◽  
Cross Sectional ◽  
The Relationship

ObjectiveAlthough fibroblast growth factor 23 (FGF23) has been implicated in the pathogenesis of cardiovascular disease, the relationship between FGF23 and cardiovascular disease has not been well characterized in the general population. The aim of this study was to determine whether serum FGF23 is independently associated with cardiovascular disease in older community-dwelling women.Design and methodsA cross-sectional design was used to examine the relationship between serum FGF23 and cardiovascular disease. The subjects consisted of a population-based sample of 659 women, aged 70–79 years, who participated in the Women's Health and Aging Studies in Baltimore, Maryland. Prevalent cardiovascular disease (coronary heart disease, stroke, congestive heart failure, and peripheral artery disease) was assessed through diagnostic algorithms and physician adjudication.ResultsOf the 659 women, 185 (28.1%) had cardiovascular disease. Median (25th, 75th percentile) intact serum FGF23 was 34.6 (25.2, 46.2) pg/ml. The prevalence of cardiovascular disease in the lowest, middle, and highest tertile of serum FGF23 was 22.6, 24.9, and 36.7% respectively (P=0.002). Serum log FGF23 was associated with cardiovascular disease (odds ratio per 1s.d.increase=1.23, 95% confidence interval 1.17, 1.30;P<0.0001) in a multivariable logistic regression model, adjusting for age, race, smoking, education, body mass index, cognition, diabetes, hypertension, physical activity, total cholesterol, high-density lipoprotein cholesterol, and renal function.ConclusionElevated serum FGF23 concentrations are independently associated with prevalent cardiovascular disease in older community-dwelling women. Further studies are needed to elucidate the potential biological mechanisms by which FGF23 may be involved in the pathogenesis of cardiovascular disease.

scholarly journals Fibroblast Growth Factor 23, Bone Mineral Density, and Risk of Hip Fracture Among Older Adults: The Cardiovascular Health Study

2013 ◽  
Vol 98 (8) ◽  
pp. 3323-3331 ◽  
Author(s):  
Anna Jovanovich ◽  
Petra Bùžková ◽  
Michel Chonchol ◽  
John Robbins ◽  
Howard A. Fink ◽  
...  
Keyword(s):  
Older Adults ◽  
Hip Fracture ◽  
Lumbar Spine ◽  
Cardiovascular Health ◽  
Fibroblast Growth Factor 23 ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Mineral Density ◽  
Total Hip

Context: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that also inhibits calcitriol synthesis. Objective: Our objective was to evaluate the relationships of plasma FGF23 concentrations with bone mineral density (BMD) and hip fracture in community-dwelling older adults. Design and Setting: Linear regression and Cox proportional hazard models were used to examine the associations of plasma FGF23 concentrations with BMD and incident hip fracture, respectively. Analyses were also stratified by chronic kidney disease. Participants: Participants included 2008 women and 1329 men ≥65 years from the 1996 to 1997 Cardiovascular Health Study visit. Main Outcome Measures: Dual x-ray absorptiometry measured total hip (TH) and lumbar spine (LS) BMD in 1291 participants. Hip fracture incidence was assessed prospectively through June 30, 2008 by hospitalization records in all participants. Results: Women had higher plasma FGF23 concentrations than men (75 [56–107] vs 66 [interquartile range = 52–92] relative units/mL; P &lt; .001). After adjustment, higher FGF23 concentrations were associated with greater total hip and lumbar spine BMD in men only (β per doubling of FGF23 = 0.02, with 95% confidence interval [CI] = 0.001–0.04 g/cm2, and 0.03 with 95% CI = 0.01–0.06 g/cm2). During 9.6 ± 5.1–11.0 years of follow-up, 328 hip fractures occurred. Higher FGF23 concentrations were not associated with hip fracture risk in women or men (adjusted hazard ratio = 0.95, with 95% CI = 0.78–1.15, and 1.09 with 95% CI = 0.82–1.46 per doubling of FGF23). Results did not differ by chronic kidney disease status (P &gt; .4 for interactions). Conclusions: In this large prospective cohort of community-dwelling older adults, higher FGF23 concentrations were weakly associated with greater lumbar spine and total hip BMD but not with hip fracture risk.

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