scholarly journals Impaired Olfaction and Risk of Delirium or Cognitive Decline After Cardiac Surgery

2015 ◽  
Vol 63 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Charles H. Brown ◽  
Candice Morrissey ◽  
Masahiro Ono ◽  
Gayane Yenokyan ◽  
Ola A. Selnes ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cognitive Decline

Preoperative Cerebral Hypoperfusion in the Left, Not in the Right, Hemisphere Is Associated With Cognitive Decline After Cardiac Surgery

2012 ◽  
Vol 74 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Simone Messerotti Benvenuti ◽  
Paolo Zanatta ◽  
Carolina Longo ◽  
Anna Paola Mazzarolo ◽  
Daniela Palomba
Keyword(s):  
Cardiac Surgery ◽  
Cognitive Decline ◽  
Right Hemisphere ◽  
Cerebral Hypoperfusion ◽  
The Right

scholarly journals Is postoperative cognitive decline after cardiac surgery associated with plasma beta amyloid 1–42 levels?

2022 ◽  
Vol 17 (1) ◽  
Author(s):  
Zrinka Požgain ◽  
Grgur Dulić ◽  
Goran Kondža ◽  
Siniša Bogović ◽  
Ivan Šerić ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Cognitive Decline ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Off Pump ◽  
Bypass Group ◽  
Postoperative Cognitive Decline ◽  
Pump Coronary Artery Bypass

Abstract Background Postoperative cognitive decline following cardiac surgery is one of the frequently reported complications affecting postoperative outcome, characterized by impairment of memory or concentration. The aetiology is considered multifactorial and the research conducted so far has presented contradictory results. The proposed mechanisms to explain the cognitive decline associated with cardiac surgery include the neurotoxic accumulation of β-amyloid (Aβ) proteins similar to Alzheimer's disease. The comparison of coronary artery bypass grafting procedures concerning postoperative cognitive decline and plasmatic Aβ1-42 concentrations has not yet been conducted. Methods The research was designed as a controlled clinical study of patients with coronary artery disease undergoing surgical myocardial revascularization with or without the use of a cardiopulmonary bypass machine. All patients completed a battery of neuropsychological tests and plasmatic Aβ1-42 concentrations were collected. Results The neuropsychological test results postoperatively were significantly worse in the cardiopulmonary bypass group and the patients had larger shifts in the Aβ1-42 preoperative and postoperative values than the group in which off-pump coronary artery bypass was performed. Conclusions The conducted research confirmed the earlier suspected association of plasmatic Aβ1-42 concentration to postoperative cognitive decline and the results further showed that there were less changes and lower concentrations in the off-pump coronary artery bypass group, which correlated to less neurocognitive decline. There is a lot of clinical contribution acquired by this research, not only in everyday decision making and using amyloid proteins as biomarkers, but also in the development and application of non-pharmacological and pharmacological neuroprotective strategies.

Cerebral Oxygen Desaturation Predicts Cognitive Decline and Longer Hospital Stay After Cardiac Surgery

2009 ◽  
Vol 87 (1) ◽  
pp. 36-45 ◽  
Author(s):  
James P. Slater ◽  
Theresa Guarino ◽  
Jessica Stack ◽  
Kateki Vinod ◽  
Rami T. Bustami ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cognitive Decline ◽  
Hospital Stay ◽  
Oxygen Desaturation ◽  
Cerebral Oxygen
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