scholarly journals Gastroprotective Agent Underuse in High-Risk Older Daily Nonsteroidal Anti-Inflammatory Drug Users over Time

2014 ◽  
Vol 62 (10) ◽  
pp. 1923-1927 ◽  
Author(s):  
Zachary A. Marcum ◽  
Joseph T. Hanlon ◽  
Elsa S. Strotmeyer ◽  
Anne B. Newman ◽  
Ronald I. Shorr ◽  
...  
Keyword(s):  
High Risk ◽  
Drug Users ◽  
Inflammatory Drug ◽  
Gastroprotective Agent ◽  
Anti Inflammatory ◽  
Over Time

Non-steroidal anti-inflammatory drug use and prostate cancer in a high-risk population

2006 ◽  
Vol 15 (2) ◽  
pp. 158-164 ◽  
Author(s):  
Salaheddin M. Mahmud ◽  
Simon Tanguay ◽  
Louis R. Bégin ◽  
Eduardo L. Franco ◽  
Armen G. Aprikian
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Drug Use ◽  
High Risk Population ◽  
Risk Population ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Non-Genetic Reprogramming of Monocytes via Microparticle Phagocytosis for Sustained Modulation of Macrophage Phenotype

2019 ◽  
Author(s):  
Kathryn L. Wofford ◽  
Bhavani S. Singh ◽  
D. Kacy Cullen ◽  
Kara L. Spiller
Keyword(s):  
Cell Therapy ◽  
Inflammatory Factors ◽  
Macrophage Phenotype ◽  
Vast Number ◽  
Inflammatory Drug ◽  
Rapid Acquisition ◽  
Therapy Strategy ◽  
Inflammatory Phenotype ◽  
Anti Inflammatory ◽  
Over Time

ABSTRACTMonocyte-derived macrophages orchestrate tissue regeneration by homing to sites of injury, phagocytosing pathological debris, and stimulating other cell types to repair the tissue. Accordingly, monocytes have been investigated as a translational and potent source for cell therapy, but their utility has been hampered by their rapid acquisition of a pro-inflammatory phenotype in response to the inflammatory injury microenvironment. To overcome this problem, we designed a cell therapy strategy where we collect and exogenously reprogram monocytes by intracellularly loading the cells with biodegradable microparticles containing an anti-inflammatory drug in order to modulate and maintain an anti-inflammatory phenotype over time. To test this concept, poly(lactic-co-glycolic) acid microparticles were loaded with the anti-inflammatory drug dexamethasone (Dex) and administered to primary human monocytes for four hours to facilitate phagocytic uptake. After removal of non-phagocytosed microparticles, microparticle-loaded monocytes differentiated into macrophages and stored the microparticles intracellularly for several weeks in vitro, releasing drug into the extracellular environment over time. Cells loaded with intracellular Dex microparticles showed decreased expression and secretion of inflammatory factors even in the presence of pro-inflammatory stimuli up to 7 days after microparticle uptake compared to untreated cells or cells loaded with blank microparticles. This study represents a new strategy for long-term maintenance of anti-inflammatory macrophage phenotype using a translational monocyte-based cell therapy strategy without the use of genetic modification. Because of the ubiquitous nature of monocyte-derived macrophage involvement in pathology and regeneration, this strategy holds potential as a treatment for a vast number of diseases and disorders.

Chronic Nonsteroidal Anti-Inflammatory Drug Users and Incidence of Endoscopically Documented Peptic Ulcer

2006 ◽  
Vol 63 (5) ◽  
pp. AB165
Author(s):  
Giorgio Talamini ◽  
Pietro Minuz ◽  
Benedetta Pajusco ◽  
Alessandro Lechi ◽  
Italo Vantini
Keyword(s):  
Peptic Ulcer ◽  
Drug Users ◽  
Inflammatory Drug ◽  
Anti Inflammatory
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