Effects of codeine on esophageal peristalsis in humans using high resolution manometry

2021 ◽  
Author(s):  
Chien‐Lin Chen ◽  
Ming‐Wun Wong ◽  
Jui‐Sheng Hung ◽  
Shu‐Wei Liang ◽  
Tso‐Tsai Liu ◽  
...  
Keyword(s):  
High Resolution ◽  
Esophageal Peristalsis ◽  
High Resolution Manometry

scholarly journals Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease

2019 ◽  
Vol 21 (11) ◽  
Author(s):  
K. Nikaki ◽  
A. Sawada ◽  
A. Ustaoglu ◽  
D. Sifrim
Keyword(s):  
High Resolution ◽  
Smooth Muscles ◽  
Circular Muscle ◽  
Esophageal Disease ◽  
Esophageal Peristalsis ◽  
High Resolution Manometry ◽  
Neuronal Control ◽  
Neuronal Mechanisms ◽  
Main Factors ◽  
Contraction And Relaxation

Abstract Purpose of Review Esophageal peristalsis is a highly sophisticated function that involves the coordinated contraction and relaxation of striated and smooth muscles in a cephalocaudal fashion, under the control of central and peripheral neuronal mechanisms and a number of neurotransmitters. Esophageal peristalsis is determined by the balance of the intrinsic excitatory cholinergic, inhibitory nitrergic and post-inhibitory rebound excitatory output to the esophageal musculature. Recent Findings Dissociation of the longitudinal and circular muscle contractions characterizes different major esophageal disorders and leads to esophageal symptoms. Provocative testing during esophageal high-resolution manometry is commonly employed to assess esophageal body peristaltic reserve and underpin clinical diagnosis. Summary Herein, we summarize the main factors that determine esophageal peristalsis and examine their role in major and minor esophageal motility disorders and eosinophilic esophagitis.

scholarly journals Topographical plots of esophageal distension and contraction: effects of posture on esophageal peristalsis and bolus transport

2019 ◽  
Vol 316 (4) ◽  
pp. G519-G526 ◽  
Author(s):  
Ali Zifan ◽  
Hyun Joo Song ◽  
Young-Hoon Youn ◽  
Xinhuan Qiu ◽  
Melissa Ledgerwood-Lee ◽  
...  
Keyword(s):  
High Resolution ◽  
Healthy Subjects ◽  
Temporal Relationship ◽  
Entire Length ◽  
Esophageal Peristalsis ◽  
Descending Inhibition ◽  
Position Change ◽  
Trendelenburg Position ◽  
High Resolution Manometry ◽  
Esophageal Contraction

Each swallow induces a wave of inhibition followed by contraction in the esophagus. Unlike contraction, which can easily be measured in humans using high-resolution manometry (HRM), inhibition is difficult to measure. Luminal distension is a surrogate of the esophageal inhibition. The aim of this study was to determine the effect of posture on the temporal and quantitative relationship between distension and contraction along the entire length of the esophagus in normal healthy subjects by using concurrent HRM, HRM impedance (HRMZ), and intraluminal ultrasound (US). Studies were conducted in 15 normal healthy subjects in the supine and Trendelenburg positions. Both manual and automated methods were used to extract quantitative pressure and impedance-derived features from the HRMZ recordings. Topographical plots of distension and contraction were visualized along the entire length of the esophagus. Distension was also measured from the US images during 10-ml swallows at 5 cm above the lower esophageal sphincter. Each swallow was associated with luminal distension followed by contraction, both of which traversed the esophagus in a sequential/peristaltic fashion. Luminal distension (US) and esophageal contraction amplitude were greater in the Trendelenburg compared with the supine position. Length of esophageal breaks (in the transition zone) were reduced in the Trendelenburg position. Change in posture altered the temporal relationship between distension and contraction, and bolus traveled closer to the esophageal contraction in the Trendelenburg position. Topographical contraction-distension plots derived from HRMZ recordings is a novel way to visualize esophageal peristalsis. Future studies should investigate if abnormalities of esophageal distension are the cause of functional dysphagia. NEW & NOTEWORTHY Ascending contraction and descending inhibition are two important components of peristalsis. High-resolution manometry only measures the contraction phase of peristalsis. We measured esophageal distension from intraluminal impedance recordings and developed novel contraction-distension topographical plots to prove that similar to contraction, distension also travels in a peristaltic fashion. Change in posture from the supine to the Trendelenburg position also increased the amplitude of esophageal distension and contraction and altered the temporal relationship between distension and contraction.

Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers

2006 ◽  
Vol 290 (5) ◽  
pp. G988-G997 ◽  
Author(s):  
Sudip K. Ghosh ◽  
John E. Pandolfino ◽  
Qing Zhang ◽  
Andrew Jarosz ◽  
Nimeesh Shah ◽  
...  
Keyword(s):  
High Resolution ◽  
Transition Zone ◽  
Contractile Activity ◽  
Normative Values ◽  
Esophageal Peristalsis ◽  
Data Set ◽  
High Resolution Manometry ◽  
Asymptomatic Volunteers ◽  
Temporal And Spatial Characteristics ◽  
Novel Concept

The vastly enhanced spatial resolution of high-resolution manometry (HRM) makes it possible to simultaneous monitor contractile activity over the entire length of the esophagus. The aim of this investigation was to define the essential features of esophageal peristalsis in novel HRM paradigms and establish their normative values. Ten 5-ml water swallows were recorded in each of 75 asymptomatic controls with a solid-state manometric assembly incorporating 36 circumferential sensors spaced at 1-cm intervals positioned to record from the hypopharynx to the stomach. The data set was then subjected to intensive computational analysis to distill out the essential characteristics of normal peristalsis. Esophageal peristalsis was conceptualized in terms of a proximal contraction, a distal contraction, and a transition zone separating the two. Each contractile segment was quantified in length and then normalized among subjects to summarize focal fluctuation of contractile amplitude and propagation velocity. Furthermore, the temporal and spatial characteristics of the transition zone separating the proximal and distal contraction were quantified. For each paradigm, graphics were developed, establishing median values along with the 5th to 95th percentile range of observed variation. In addition, the synchronization between peristalsis and esophagogastric junction relaxation was analyzed using a novel concept of the outflow permissive pressure gradient. We performed a detailed analysis of esophageal peristalsis aimed at quantifying its essential features and, in so doing, devised new paradigms for the quantification of peristaltic function that will hopefully optimize the utility of HRM in clinical and investigative studies.

W1863 Esophageal Peristalsis Variants in Scleroderma Patients: A High-Resolution Manometry Study

2009 ◽  
Vol 136 (5) ◽  
pp. A-742
Author(s):  
Sudip K. Ghosh ◽  
Virender K. Sharma ◽  
Paula M. Dionisio ◽  
Michael D. Crowell
Keyword(s):  
High Resolution ◽  
Esophageal Peristalsis ◽  
High Resolution Manometry
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