scholarly journals Hemostatic powder TC‐325 treatment of malignancy related upper gastrointestinal bleeds: International registry outcomes

2021 ◽  
Author(s):  
Mohamed Hussein ◽  
Durayd Alzoubaidi ◽  
Michael O'Donnell ◽  
Alvaro Serna ◽  
Paul Bassett ◽  
...  
Keyword(s):  
International Registry ◽  
Hemostatic Powder ◽  
Upper Gastrointestinal

scholarly journals Efficacy of a novel hemostatic adhesive powder in patients with upper gastrointestinal tumor bleeding

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jongbeom Shin ◽  
Boram Cha ◽  
Jin-Seok Park ◽  
Weonjin Ko ◽  
Kye Sook Kwon ◽  
...  
Keyword(s):  
Success Rate ◽  
Salvage Therapy ◽  
Upper Gastrointestinal Bleeding ◽  
Effective Control ◽  
Success Rates ◽  
Gastrointestinal Tumor ◽  
Bleeding Rate ◽  
Tumor Bleeding ◽  
Hemostatic Powder ◽  
Upper Gastrointestinal

Abstract Background Gastrointestinal tumor bleeding remains a clinical challenge because it is difficult to treat with conventional endoscopic hemostatic options. Recently, an endoscopic hemostatic powder (UI-EWD) was developed and reported to provide effective control of upper gastrointestinal bleeding. The aim of current study was to evaluate the feasibility and efficacy of this novel hemostatic powder in tumor bleeding. Methods A total of 41 consecutive patients with upper gastrointestinal tumor bleeding were included. UI-EWD was applied in all patients as an auxiliary hemostatic method as a salvage therapy or monotherapy during endoscopic treatment. Hemostasis success rates, adverse event related to UI-EWD, and rates of re-bleeding were evaluated. Results In all cases, UI-EWD application was successful at tumor bleeding sites. Immediate hemostasis occurred in 40/41 (97.5%) patients, and re-bleeding within 28 days occurred in 10 of 40 (22.5%) patients that achieved initial hemostasis. The success rate of immediate hemostasis for UI-EWD monotherapy was 100% (23/23). The re-bleeding rate at 28 days after UI-EWD monotherapy was 26.1% (6/23). No adverse events associated with UI-EWD application were encountered. Conclusions The success rate of UI-EWD for immediate hemostasis in cases of GI tumor bleeding was excellent and UI-EWD produced promising results with respect to the prevention of re-bleeding. Based on these results, we suggest that UI-EWD be considered an effective salvage therapy or even monotherapy for GI tumor bleeding.

scholarly journals Use of hemostatic powder in treatment of upper gastrointestinal bleeding: a systematic review and meta-analysis

2019 ◽  
Vol 07 (12) ◽  
pp. E1704-E1713 ◽  
Author(s):  
Daniel Tavares de Rezende ◽  
Vitor Ottoboni Brunaldi ◽  
Wanderley Marques Bernardo ◽  
Igor Braga Ribeiro ◽  
Raquel Cristina Lins Mota ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Bleeding ◽  
Latin American ◽  
Upper Gastrointestinal Bleeding ◽  
Rescue Therapy ◽  
Meta Analysis ◽  
Secondary Outcome ◽  
Primary Hemostasis ◽  
Hemostatic Powder ◽  
Upper Gastrointestinal

Abstract Background and study aims TC-325 is a novel mineral hemostatic powder that creates a mechanical barrier by absorbing blood components and promoting clotting. Recently approved for use in humans, it has shown promise for treatment of upper gastrointestinal bleeding (UGIB). However, because there have been no large studies of TC-325, its true efficacy and safety profile remain unknown. We performed a systematic review and meta-analysis to determine the safety and efficacy of TC-325 in treating UGIB, based on rates of initial hemostasis, rebleeding, and adverse events (AEs). Methods We searched the MEDLINE/PubMed, EMBASE, CENTRAL, Latin-American and Caribbean Health Sciences Literature databases, as well as the gray literature, to identify articles describing use of TC-325 up to October 2018. Primary outcomes were initial hemostasis and rebleeding. AEs were described as a secondary outcome. Risk of bias was assessed with international scores. Results We identified 2077 records after removal of duplicates. We included 50 studies, involving a collective total of 1445 patients, in the quantitative synthesis. Primary hemostasis and rebleeding rates were 90.7 % and 26.1 %, respectively. Subgroup analyses showed similar results. Only eight AEs were reported. Conclusions TC-325 appears to be a safe, effective treatment for UGIB. The overall rate of initial hemostasis after TC-325 use is high, regardless of etiology of bleeding or whether TC-325 is used as a primary or rescue therapy. Although it is also associated with high rebleeding rates, rates of AEs and equipment failure after TC-325 use are extremely low.

Tu1094 THE USE OF HEMOSTATIC POWDER IN UPPER GASTROINTESTINAL BLEEDING: A SYSTEMATIC REVIEW AND META-ANALYSIS

2019 ◽  
Vol 89 (6) ◽  
pp. AB553
Author(s):  
Daniel T. Rezende ◽  
Wanderlei M. Bernardo ◽  
Vitor O. Brunaldi ◽  
Igor B. Ribeiro ◽  
Sérgio E. Matuguma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gastrointestinal Bleeding ◽  
Upper Gastrointestinal Bleeding ◽  
Meta Analysis ◽  
Hemostatic Powder ◽  
Upper Gastrointestinal

A novel hemostatic powder for upper gastrointestinal bleeding: a multicenter study (the “GRAPHE” registry)

Endoscopy ◽  
2016 ◽  
Vol 48 (12) ◽  
pp. 1084-1095 ◽  
Author(s):  
Sami Haddara ◽  
Jeremie Jacques ◽  
Stéphane Lecleire ◽  
Julien Branche ◽  
Sarah Leblanc ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Multicenter Study ◽  
Upper Gastrointestinal Bleeding ◽  
Hemostatic Powder ◽  
Upper Gastrointestinal

scholarly journals Severe upper gastrointestinal bleeding is halted by endoscopically delivered self-propelling thrombin powder: A porcine pilot study

2021 ◽  
Vol 09 (05) ◽  
pp. E693-E698
Author(s):  
Nabil Ali-Mohamad ◽  
Massimo Cau ◽  
James Baylis ◽  
Veronika Zenova ◽  
Hugh Semple ◽  
...  
Keyword(s):  
Pilot Study ◽  
Gastrointestinal Bleeding ◽  
Upper Gastrointestinal Bleeding ◽  
Vascular Bundles ◽  
Average Mass ◽  
Primary Hemostasis ◽  
Needle Knife ◽  
Hemostatic Powder ◽  
Mean Time ◽  
Upper Gastrointestinal

Abstract Background and study aims Hemostatic powders have emerged recently to treat upper gastrointestinal bleeding (UGIB). Previously, we developed a novel self-propelling thrombin powder (SPTP) that effectively manages external pulsatile arterial bleed without compression, by effervescing and carrying thrombin into the wound. Here, we tested if SPTP, sprayed endoscopically, can manage severe UGIB in a live porcine model. Materials and methods Anesthetized pigs underwent laparotomy to insert the gastroepiploic vascular bundles into the stomach lumen via a gastrotomy. Bleeding was initiated endoscopically in the stomach by needle knife. SPTP was delivered to the site of bleeding from a CO2-powered spray device using a 7 FR catheter. Successful primary hemostasis, time to hemostasis, and the mass of SPTP delivered were measured. Results Hemostasis was achieved at all bleeding sites using SPTP. Mean time to hemostasis was 4.2 ± 0.9 minutes (mean ± standard error of the mean, n = 12). The average mass of SPTP delivered was 2.4 ± 0.6 g. Conclusions In this pilot study, SPTP successfully stopped 12 cases of severe UGIB, demonstrating early promise asa novel hemostatic powder.

Randomized controlled trial of hemostatic powder versus endoscopic clipping for non-variceal upper gastrointestinal bleeding

2019 ◽  
Vol 34 (1) ◽  
pp. 317-324 ◽  
Author(s):  
Felipe Iankelevich Baracat ◽  
Diogo Turiani Hourneaux de Moura ◽  
Vítor Ottoboni Brunaldi ◽  
Caio Vinicius Tranquillini ◽  
Renato Baracat ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Gastrointestinal Bleeding ◽  
Upper Gastrointestinal Bleeding ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Hemostatic Powder ◽  
Endoscopic Clipping ◽  
Upper Gastrointestinal

scholarly journals Tu1478 NOVEL HEMOSTATIC POWDER STOPS BLEEDING IN A LIVE PROCINE MODEL OF UPPER GASTROINTESTINAL BLEEDING

2020 ◽  
Vol 91 (6) ◽  
pp. AB581
Author(s):  
Fergal Donnellan ◽  
Nabil Ali-Mohamad ◽  
Massimo Cau ◽  
James Baylis ◽  
Veronika Zenova ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Upper Gastrointestinal Bleeding ◽  
Hemostatic Powder ◽  
Upper Gastrointestinal
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