Risk factors for rebleeding in Crohn's disease patients with acute severe lower gastrointestinal bleeding: With special reference to the role of anti‐tumor necrosis factor therapy

2021 ◽  
Author(s):  
Dae Sung Kim ◽  
Jiyoung Yoon ◽  
Ye‐Jee Kim ◽  
Jin Wook Lee ◽  
Seung Wook Hong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Crohn’S Disease ◽  
Tumor Necrosis Factor ◽  
Gastrointestinal Bleeding ◽  
Special Reference ◽  
Tumor Necrosis ◽  
Lower Gastrointestinal Bleeding ◽  
Factor Therapy ◽  
Necrosis Factor

Incidence and Risk Factors of Legionella pneumophila Pneumonia During Anti-Tumor Necrosis Factor Therapy

CHEST Journal ◽  
2013 ◽  
Vol 144 (3) ◽  
pp. 990-998 ◽  
Author(s):  
Fanny Lanternier ◽  
Florence Tubach ◽  
Philppe Ravaud ◽  
Dominique Salmon ◽  
Pierre Dellamonica ◽  
...  
Keyword(s):  
Risk Factors ◽  
Tumor Necrosis Factor ◽  
Legionella Pneumophila ◽  
Tumor Necrosis ◽  
Factor Therapy ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor-αand Interleukin-6: Potential Interorgan Inflammatory Mediators Contributing to Destructive Periodontal Disease in Obesity or Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Roozbeh Khosravi ◽  
Khady Ka ◽  
Ting Huang ◽  
Saeed Khalili ◽  
Bich Hong Nguyen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Tumor Necrosis Factor ◽  
Periodontal Disease ◽  
Inflammatory Mediators ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Artery Disease ◽  
Necrosis Factor

Obesity has become a worldwide health burden in the last two decades. Obesity has been associated with increased comorbidities, such as coronary artery disease, diabetes, and destructive periodontal disease. Obesity is also part of a group of risk factors occurring together in an individual, which is referred to as metabolic syndrome. Clinical studies have shown higher risk for destructive periodontal disease in obesity and metabolic syndrome. However, the role of obesity and metabolic syndrome in the onset and development of destructive periodontal disease has not yet been fully understood. In this review, we discuss a working model, which focuses on interorgan inflammation as a common etiological factor for destructive periodontal disease associated with obesity and metabolic syndrome. Specifically, we suggest that elevated levels of tumor necrosis factor-α(TNF-α) or interleukin 6 (IL-6)—both adipokines and known risk factors for destructive periodontal disease—in obesity and metabolic syndrome contribute to the onset and development of destructive periodontal disease. The connections between destructive periodontal disease and systemic conditions, such as obesity or metabolic syndrome, are complex and potentially multidirectional. This review largely focuses on TNF-αand IL-6, inflammatory mediators, as potential common risk factors and does not exclude other biological mechanisms.

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