Gut microbiota composition associated with hepatic fibrosis in non‐obese patients with non‐alcoholic fatty liver disease

2021 ◽  
Author(s):  
Michihiro Iwaki ◽  
Takaomi Kessoku ◽  
Anna Ozaki ◽  
Yuki Kasai ◽  
Takashi Kobayashi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Hepatic Fibrosis ◽  
Fatty Liver Disease ◽  
Obese Patients ◽  
Microbiota Composition ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Gut Microbiota Composition

Pure total flavonoids from citrus attenuate non-alcoholic fatty liver disease in mice via the gut microbiota

2020 ◽  
Author(s):  
Beihui He ◽  
Jianping Jiang ◽  
Zheng Shi ◽  
Dawei Cui ◽  
Sumei Xu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Total Flavonoids ◽  
Alcoholic Fatty Liver ◽  
Composition And Structure ◽  
Rdna Sequencing ◽  
Alcoholic Fatty Liver Disease ◽  
Gut Microbiota Composition

Abstract Background An increasing number of studies suggest that gut microbiota composition and structure contribute to the pathophysiology of non-alcoholic fatty liver disease(NAFLD),and the gut microbiota has been proposed as a new target in the treatment of diet-induced NAFLD. In this study, we aimed to investigate the effects of pure total flavonoids from citrus (PTFC) on NAFLD and gut microbiota dysbiosis in high-fat diet (HFD)-fed mice and to further investigate whether the attenuation of NAFLD is related to the modulation of the gut microbiota. Results PTFC intervention could significantly attenuate symptoms in mice with HFD-induced NAFLD.Based on the results of 16S rDNA sequencing, PTFC treatment could increase the phylogenetic diversity of the HFD-induced microbiota. PTFC intervention could significantly restore the HFD-induced increases in the relative abundances of Bacteroidaceae and Christensenellaceae. Conclusion Our results suggested that PTFC could serve as a novel candidate for the prevention of NAFLD by modulating the gut microbiota.

scholarly journals Diet, Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Three Parts of the Same Axis

Cells ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 176 ◽  
Author(s):  
Sergio Quesada-Vázquez ◽  
Gerard Aragonès ◽  
Josep M Del Bas ◽  
Xavier Escoté
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Close Relation ◽  
Alcoholic Fatty Liver ◽  
Liver Functions ◽  
Specific Species ◽  
Alcoholic Fatty Liver Disease ◽  
Gut Microbiota Composition

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the world. NAFLD is principally characterized by an excessive fat accumulation in the hepatocytes. Diet is considered as one of the main drivers to modulate the composition of gut microbiota, which participate in different processes, affecting human metabolism. A disruption in the homeostasis of gut microbiota may lead to dysbiosis, which is commonly reflected by a reduction of the beneficial species and an increment in pathogenic microbiota. Gut and liver are in close relation due to the anatomical and functional interactions led by the portal vein, thus altered intestinal microbiota might affect liver functions, promoting inflammation, insulin resistance and steatosis, which is translated into NAFLD. This review will highlight the association between diet, gut microbiota and liver, and how this axis may promote the development of NAFLD progression, discussing potential mechanisms and alterations due to the dysbiosis of gut microbiota. Finally, it will revise the variations in gut microbiota composition in NAFLD, and it will focus in specific species, which directly affect NAFLD progression.

scholarly journals Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review

Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1719
Author(s):  
Valentina Castillo ◽  
Fernanda Figueroa ◽  
Karoll González-Pizarro ◽  
Paz Jopia ◽  
Claudia Ibacache-Quiroga
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Communicable Disease ◽  
Anthropometric Parameters ◽  
Alcoholic Fatty Liver ◽  
Risks Factors ◽  
Alcoholic Fatty Liver Disease ◽  
Non Communicable Disease

Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease, with a prevalence of 25% worldwide. This pathology is a multifactorial illness, and is associated with different risks factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. Beside these predisposing features, NAFLD has been related to changes in the microbiota, which favor the disease progression. In this context, the modulation of the gut microbiota has emerged as a new therapeutic target for the prophylaxis and treatment of NAFLD. This review describes the changes in the gut microbiota associated with NAFLD and the effect of probiotics, prebiotics, and synbiotics on the gut microbiota, liver damage, anthropometric parameters, blood lipids, inflammation markers and insulin resistance in these patients.

Sa1055 Use of Insulin and Sulfonylurea Is Associated With Hepatic Fibrosis in Diabetic Patients With Non-Alcoholic Fatty Liver Disease

2014 ◽  
Vol 146 (5) ◽  
pp. S-948
Author(s):  
George Boon-Bee Goh ◽  
Jaividhya Dasarathy ◽  
Mangesh R. Pagadala ◽  
Aynur Unalp ◽  
Carol Hawkins ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Hepatic Fibrosis ◽  
Fatty Liver Disease ◽  
Diabetic Patients ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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