scholarly journals Environmental factors associated with biological use and surgery in inflammatory bowel disease

2020 ◽  
Author(s):  
Kimberley W J Sloot ◽  
Paul Geertsema ◽  
Hanneke C Rijkmans ◽  
Michiel D Voskuil ◽  
Hendrik M Dullemen ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Environmental Factors ◽  
Bowel Disease ◽  
Factors Associated ◽  
Inflammatory Bowel

scholarly journals Identification of Environmental Risk Factors Associated With the Development of Inflammatory Bowel Disease

2020 ◽  
Vol 14 (12) ◽  
pp. 1662-1671
Author(s):  
Kimberley W J van der Sloot ◽  
Rinse K Weersma ◽  
Behrooz Z Alizadeh ◽  
Gerard Dijkstra
Keyword(s):  
Inflammatory Bowel Disease ◽  
Environmental Factors ◽  
Bowel Disease ◽  
Multiple Testing ◽  
Stressful Life Events ◽  
Population Based ◽  
Factors Associated ◽  
Disease Aetiology ◽  
Inflammatory Bowel ◽  
Genetic And Environmental Factors

Abstract Background and Aims Multiple genetic and environmental factors are involved in the aetiology of inflammatory bowel disease [IBD] including Crohn’s disease [CD] and ulcerative colitis [UC], but data on these exposome factors are difficult to identify. Several exposome factors such as smoking have been shown to be involved; as for other environmental factors, eg stress, results have been conflicting. Methods We performed a case-control study including 674 IBD patients of the 1000IBD cohort, frequency-matched based on sex and age with 1348 controls from the population-based Lifelines Cohort Study. Exposome data were obtained using the validated Groningen IBD Environmental Questionnaire [GIEQ], capturing exposome factors through different stages of life using 844 items, of which 454 were applicable to study the role of 93 exposome factors in disease aetiology. Logistic regression [LR] modelling with Bonferroni correction for multiple testing was applied to estimate the multivariable-adjusted effect of each exposome factor. Results For IBD, we identified four novel factors: stressful life events (CD odds ratio [OR] 2.61/UC OR 2.92), high perceived stress [2.29/2.67], alcohol use [0.40/0.43], and bronchial hyper-reactivity [3.04/2.36]. Four novel factors were associated with only CD: prenatal smoke exposure [1.89], having a bed partner [0.53], allergies [2.66], and cow’s milk hypersensitivity [5.87]; and two solely with UC: carpet flooring [0.57] and neuroticism [1.32]. Nine factors were replicated. Conclusions In this study we identified 10 novel, and replicated nine previously reported, exposome factors associated with IBD. Identifying these factors is important for both understanding disease aetiology and future prevention strategies to decrease the development of IBD in genetically susceptible persons.

Atherosclerosis and Inflammatory Bowel Disease—Shared Pathogenesis and Implications for Treatment

Angiology ◽  
2020 ◽  
pp. 000331972097455
Author(s):  
Nikolaos Kamperidis ◽  
Vasileios Kamperidis ◽  
Thomas Zegkos ◽  
Ioanna Kostourou ◽  
Olga Nikolaidou ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Heart Disease ◽  
Environmental Factors ◽  
Ischemic Heart Disease ◽  
Bowel Disease ◽  
Ischemic Heart ◽  
Factors Associated ◽  
Current Review ◽  
Inflammatory Bowel ◽  
The Common

Atherosclerosis and inflammatory bowel disease (IBD) are often regarded as 2 distinct entities. The commonest manifestation of atherosclerosis is ischemic heart disease (IHD), and an association between IHD and IBD has been reported. Atherosclerosis and IBD share common pathophysiological mechanisms in terms of their genetics, immunology, and contributing environmental factors. Factors associated with atherosclerosis are implicated in the development of IBD and vice versa. Therefore, treatments targeting the common pathophysiology pathways may be effective in both conditions. The current review considers the pathophysiological pathways that are shared between the 2 conditions and discusses the implications for treatment and research.

scholarly journals Factors associated with vitamin D deficiency in a multicultural inflammatory bowel disease cohort

2012 ◽  
Vol 4 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Sukhdev Chatu ◽  
Vivek Chhaya ◽  
Rosamund Holmes ◽  
Penny Neild ◽  
Jin-Yong Kang ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Factors Associated ◽  
Inflammatory Bowel

scholarly journals Frequency of and Factors Associated With Sexual Dysfunction in Patients With Inflammatory Bowel Disease

2017 ◽  
Vol 11 (11) ◽  
pp. 1347-1352 ◽  
Author(s):  
P Rivière ◽  
C Zallot ◽  
P Desobry ◽  
J M Sabaté ◽  
J Vergniol ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Sexual Dysfunction ◽  
Bowel Disease ◽  
Factors Associated ◽  
Inflammatory Bowel

scholarly journals Factors Associated with Vaccination among Inflammatory Bowel Disease Patients in Korea

2013 ◽  
Vol 61 (4) ◽  
pp. 203 ◽  
Author(s):  
Hwan Sic Yun ◽  
Yang Won Min ◽  
Dong Kyoung Chang ◽  
Poong-Lyul Rhee ◽  
Jae J. Kim ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Factors Associated ◽  
Inflammatory Bowel
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