Prevalence of serrated lesions, risk factors, and their association with synchronous advanced colorectal neoplasia in asymptomatic screened individuals

2020 ◽  
Vol 35 (11) ◽  
pp. 1938-1944
Author(s):  
Masau Sekiguchi ◽  
Yasuo Kakugawa ◽  
Minori Matsumoto ◽  
Keiko Nakamura ◽  
Yasuhiko Mizuguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Colorectal Neoplasia ◽  
Advanced Colorectal Neoplasia ◽  
Serrated Lesions

Tu1546 Risk Factors of Advanced Colorectal Neoplasia in Surveillance Colonoscopy

2011 ◽  
Vol 73 (4) ◽  
pp. AB443
Author(s):  
Ja Seol Koo ◽  
Bo Sung Kwon ◽  
Seung Young Kim ◽  
Sung Woo Jung ◽  
Beom Jae Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Colorectal Neoplasia ◽  
Surveillance Colonoscopy ◽  
Advanced Colorectal Neoplasia

Predictors of advanced colorectal neoplasia in colorectal cancer screening – interim results of multicentric prospective study

2020 ◽  
Vol 74 (5) ◽  
pp. 386-392
Author(s):  
Tomáš Grega ◽  
Gabriela Vojtěchová ◽  
Michal Voška ◽  
Ondřej Májek ◽  
Miroslav Zavoral ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Prospective Study ◽  
Colorectal Neoplasia ◽  
Serum Triglyceride ◽  
Screening Colonoscopy ◽  
Factors Associated ◽  
Primary Screening ◽  
Advanced Colorectal Neoplasia ◽  
Screening Population

ntroduction: The incidence of advanced colorectal neoplasia in the screening population shows great diversity with a prevalence of 3–12 %. Due to the uneven distribution in the population, potential risk factors that would allow the stratification of individuals according to the degree of risk of colorectal neoplasia are searched. Aim: To determine the risk factors associated with the occurrence of advanced colorectal neoplasia in the screening population. Methods: Asymptomatic individuals aged 45–75 years who underwent preventive colonoscopy in 2012–2016 in a multicenter prospective study monitoring metabolic risk factors for CRC (MRF CRC study) were included in the analysis. Data were analyzed using descriptive statistics. The Fisher’s exact test was used to compare the risk factors with the occurrence of advanced colorectal neoplasia. Results: There were 1,108 men (56.3%) and 859 women (43.7%) in the group; the average age of the individuals was 60 years. The majority of subjects were referred for primary screening colonoscopy (1,174 subjects; 59.7%) and 793 subjects (40.3%) underwent FOBT positive colonoscopy. The total number of advanced colorectal neoplasms in the cohort was 11,8% (233 individuals). The independent risk factors significantly associated with advanced colorectal neoplasia included age (p < 0.001), male gender (p = 0.001), smoking (p < 0.001), serum concentrations of triglycerides (p = 0.029; especially concentrations > 2 mmol/l) and low vitamin D (p = 0.033). These are preliminary results which will be specified in the following more detailed data analysis using logistic regression. Conclusion: The strongest risk factors associated with advanced colorectal neoplasia were age, gender and smoking. In addition to these factors, serum triglyceride levels and low vitamin D were significantly associated with advanced colorectal neoplasia. In the individuals with a higher incidence of advanced colorectal neoplasia according to the given factors, primary screening colonoscopy should be considered.

scholarly journals S339 Risk Factors for Advanced Colorectal Neoplasia in Veterans Under Age 50

2021 ◽  
Vol 116 (1) ◽  
pp. S147-S147
Author(s):  
Timothy Yen ◽  
Jack Scolaro ◽  
Viridiana Estrada ◽  
Jeannine M. Espinoza ◽  
Eric M. Montminy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Colorectal Neoplasia ◽  
Advanced Colorectal Neoplasia

Risk Factors for Metachronous Advanced Colorectal Neoplasia in a Cohort of Adenoma Patients: Advanced Morphology and Multiplicity

2011 ◽  
Vol 140 (5) ◽  
pp. S-183
Author(s):  
Else-Mariette B. van Heijningen ◽  
Iris Lansdorp-Vogelaar ◽  
Vincent de Jonge ◽  
Ewout W Steyerberg ◽  
Ernst J. Kuipers ◽  
...  
Keyword(s):  
Risk Factors ◽  
Colorectal Neoplasia ◽  
Advanced Colorectal Neoplasia

scholarly journals Yield and Efficiency of FIT Tests Alone vs. In Combination with Risk Factors for Colorectal Cancer Screening

2020 ◽  
Vol 3 ◽  
Author(s):  
Vasu Sheel ◽  
Leslie Azzis ◽  
Racehl Hinrichs ◽  
Thomas Imperiale
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
High Risk ◽  
Colorectal Neoplasia ◽  
Risk Groups ◽  
Fiscal Year ◽  
Advanced Colorectal Neoplasia ◽  
Immunochemical Test ◽  
Advanced Adenomas

Background: Although colonoscopy (CY) may be considered the best screening test for colorectal cancer (CRC), annual fecal immunochemical test (FIT), which quantifies fecal hemoglobin is a viable alternative. Countries and healthcare systems using FIT-based screening may need to prioritize which FIT positive persons requires CY sooner (e.g. within the same fiscal year). We conducted a systematic review of published literature to understand how the yield/positive predictive value (PPV) of FIT could be improved.   Study Design: We performed a search of electronic databases for articles published between 2015 and June 2020. Titles, abstracts, and full texts were independently screened. Included studies fulfilled predetermined criteria and had descriptive and quantitative data extracted. We identified studies comparing the yield of FIT for advanced colorectal neoplasia ([AN], CRC plus advanced adenomas) among FIT positive persons to the yield of AN when FIT is combined with risk factors (age, sex, BMI, etc.). Data were extracted to find yield and efficiency of FIT alone vs FIT plus risk factors among FIT positive persons.   Results: From 623 titles reviewed, 4 studies met inclusion criteria. The objective of the studies was to increase the yield of AN or CRC in FIT positive patients. The number needed to scope (NNS) among FIT positives to detect AN significantly decreased for each study when looking at high risk groups as yield/PPV increased. The yield with FIT alone ranged from 24% to 46% and the NNS from 2.2 to 4.1. With risk factors, yield and NNS among those at high risk were 33.2 % to 75.6% and from 1.3 to 3.0, respectively.  Conclusion and Potential Impact: This systematic review quantifies how risk factors improve the yield for AN in FIT positive persons, which is information required for countries and health care settings with limited resources that need to direct CY resources to FIT positive patients at high risk for AN.  

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