Inhibition of gastric cancer cell apoptosis by long noncoding RNA TRPM2‐AS via mitogen‐activated protein kinase and activators of transduction‐3

2020 ◽  
Author(s):  
Xianqin Zhang ◽  
Yuyou Jiang ◽  
Yan Xie ◽  
Xue Leng ◽  
Min He ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Gastric Cancer Cell ◽  
Mitogen Activated Protein Kinase ◽  
Cancer Cell Apoptosis ◽  
Mitogen Activated Protein

scholarly journals A new bisphosphonate derivative, CP, induces gastric cancer cell apoptosis via activation of the ERK1/2 signaling pathway

2013 ◽  
Vol 34 (12) ◽  
pp. 1535-1544 ◽  
Author(s):  
Hai-jun Wang ◽  
Yu Liu ◽  
Li-qiao Fan ◽  
Cai-li Han ◽  
Ye Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Gastric Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Peroxiredoxin V Inhibits Emodin-induced Gastric Cancer Cell Apoptosis via the ROS/Bcl2 Pathway

In Vivo ◽  
2019 ◽  
Vol 33 (4) ◽  
pp. 1183-1192 ◽  
Author(s):  
YONG-ZHE JIN ◽  
HU-NAN SUN ◽  
YUE LIU ◽  
DONG-HO LEE ◽  
JI-SU KIM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Gastric Cancer Cell ◽  
Cancer Cell Apoptosis

scholarly journals Long Noncoding RNA H19/miR-675 Axis Promotes Gastric Cancer via FADD/Caspase 8/Caspase 3 Signaling Pathway

2017 ◽  
Vol 42 (6) ◽  
pp. 2364-2376 ◽  
Author(s):  
Jin Yan ◽  
Yifeng Zhang ◽  
Qiang She ◽  
Xuan Li ◽  
Lei Peng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Cancer Cell ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Gastric Cancer Cell ◽  
Caspase 3 ◽  
Caspase 8 ◽  
Gastric Cancer Cell Lines

Background: Long noncoding RNA (lncRNA) H19 is emerging as a vital regulatory molecule in the progression of different types of cancer and miR-675 is reported to be embedded in H19's first exon. However, their function and specific mechanisms of action have not been fully elucidated. The aim of this study was to identify a novel lncRNA-microRNA-mRNA functional network in gastric cancer. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess the relative expression of H19 and miR-675 in normal (GES-1) and gastric cancer cell lines (SGC-7901, SGC-7901/DDP) as well as in tumor tissues. Gain and loss of function approaches were carried out to investigate the potential roles of H19/miR-675 in cell proliferation and apoptosis. Moreover, Fas associated via death domain (FADD) was validated to be the target of miR-675 via luciferase reporter assay. Western blotting was used to evaluate the protein expression of related signaling pathway. Results: In our study H19 and miR-675 were increased in gastric cancer cell lines and tissues. Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. Conclusion: Taken together, our results point to a novel regulatory pathway H19/miR-675/ FADD/caspase 8/caspase 3 in gastric cancer which may be potential target for cancer therapy.

scholarly journals Long noncoding RNA PCAT6 inhibits colon cancer cell apoptosis by regulating anti-apoptotic protein ARC expression via EZH2

Cell Cycle ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 69-83 ◽  
Author(s):  
Weimei Huang ◽  
Geng Su ◽  
Xiaoxian Huang ◽  
Angru Zou ◽  
Jingfang Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Colon Cancer Cell ◽  
Cancer Cell Apoptosis ◽  
Apoptotic Protein

scholarly journals The long noncoding RNA colon cancer-associated transcript-1/miR-490 axis regulates gastric cancer cell migration by targeting hnRNPA1

IUBMB Life ◽  
2016 ◽  
Vol 68 (3) ◽  
pp. 201-210 ◽  
Author(s):  
Baoguo Zhou ◽  
Yuli Wang ◽  
Jinpeng Jiang ◽  
Hongpeng Jiang ◽  
Jianwei Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Colon Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Gastric Cancer Cell ◽  
Cancer Cell Migration

scholarly journals Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis

Oncotarget ◽  
2017 ◽  
Vol 8 (34) ◽  
pp. 56582-56597 ◽  
Author(s):  
Lynn H.H. Aung ◽  
Ruibei Li ◽  
Bellur S. Prabhakar ◽  
Ajay V. Maker ◽  
Peifeng Li
Keyword(s):  
Gastric Cancer ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Gastric Cancer Cell ◽  
Mitochondrial Protein ◽  
Cancer Cell Apoptosis
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